Light-induced activity in the activity box is not aversively motivated and does not show between-trial habituation

Pum, Martin; Huston, Joseph P.; Müller, Christian P.; Silva, M.A. De Souza

doi:10.1016/j.physbeh.2008.11.006

Cited by 13 publications

(20 citation statements)

References 18 publications

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“…Such presentation of a light stimulus seems not to have aversive effects, as the animals did not escape the stimulation when given an active withdrawal opportunity. Instead, they showed an exploratory orienting response towards the stimulus source (Pum et al, 2009). These observations supported earlier findings on the neuronal activity of serotonergic neurons, which is also related to visual stimulus processing and the effort involved in locomotor activity (Jacobs and Fornal, 2010).…”

Section: Introductionsupporting

confidence: 90%

“…However, anxiolytic effects were associated with the activation, not blockade, of this receptor (Kennett et al, 1996). Given that anxiety does not seem to play a substantial role in LIA (Pum et al, 2009), and that ritanserin acts as an antagonist (Baxter et al, 1995), it appears as rather unlikely that the 5-HT 2B -receptor is not involved in the ritanserin effects found in the present study. Also the 5-HT 1A -receptor, which is involved in control of spontaneous and psychostimulant drug-induced locomotor activity (Müller et al, 2007b), was not found to contribute to LIA in this study.…”

Section: No Role Of 5-ht2a- 5-ht2c-and 5-ht1a-receptors In Ritansericontrasting

confidence: 49%

“…The no-light stimulus control groups did not receive any light stimulation during the second 20 min interval. Within the stimulation interval, the presentation of a stimulus required an inter-stimulus interval of at least 30 s. Horizontal locomotion was automatically measured by the TruScan system (Müller et al, 2007a;Pum et al, 2009). …”

Section: Methodsmentioning

confidence: 99%

“…For white light stimulation, a fluorescent lamp (16 W), mounted on one of the maze walls was used. In front of the light source, Plexiglas plates were introduced to regulate stimulus intensity to 82 lux (Müller et al, 2007a;Pum et al, 2009). …”

Section: Apparatusmentioning

confidence: 99%

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Neuropharmacology of light-induced locomotor activation

et al. 2015

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Section: Introductionsupporting

confidence: 90%

Section: No Role Of 5-ht2a- 5-ht2c-and 5-ht1a-receptors In Ritansericontrasting

confidence: 49%

Section: Methodsmentioning

confidence: 99%

Section: Apparatusmentioning

confidence: 99%

See 2 more Smart Citations

Neuropharmacology of light-induced locomotor activation

et al. 2015

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“…Not only did this induce a period of motor activation, but this was accompanied by changes in cortical EEG characterized by high-frequency, low-voltage activity, which was consistent with a normalized EEG pattern. More recent work has shown that DA and 5HT may well be involved in the therapeutic effect observed after light exposure with both transmitters working to repair locomotion in the same way that they are benefi cial in treating depressive symptoms ( M ü ller and Huston, 2007a ;M ü ller et al, 2007b ;Pum et al , 2008Pum et al , , 2009 ).…”

Section: Bright-light Therapy Pd and Underlying Depressionmentioning

confidence: 99%

A historical justification for and retrospective analysis of the systematic application of light therapy in Parkinson’s disease

Willis¹,

Moore²,

Armstrong³

2012

Reviews in the Neurosciences

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For the past 40 years the primary purpose of therapeutics for Parkinson's disease (PD) has been to replace deficient dopamine (DA) in the nigrostriatal dopamine (NSD) system. Even in the presence of limited efficacy, abundant side effects and impoverished quality of life, the involvement of other systems in the aetiology and treatment of this disorder has been sorely neglected and the excessive use of DA replacement therapy (DART) continues on a global basis. Recent scientific work suggests that the retina plays a major role in NSD function and intimates light therapy in the management of PD. After a thorough review of historical evidence supporting this contention, a retrospective, open-label study on 129 PD patients, whereby they were monitored for a period extending for a few months to eight years, was carried out. Primary motor and non-motor symptoms were monitored using an objectified global rating scale and timed motor tests that were assessed at regular intervals for the duration of the study. Thirty-one patients with other neurological disorders (OND) served as controls to determine whether any therapeutic effects seen with light were generalizable across other conditions. Patients were classified as compliant (COM), semi-compliant (SCOM), or early quit (EQUIT; prematurely discontinued treatment). EQUIT patients showed deterioration, while the COM group improved on most parameters. The SCOM patients were not as good as the COM group. The OND group showed significant improvement in depression and insomnia, but exposure to light did not improve motor function. The total drug burden of PD patients maintained on light was less with fewer side effects than SCOM or EQUIT groups. These results confirm the value of the strategic application of light therapy with controlled doses of DART in PD and warrants further controlled investigation. That the symptomatic improvement continued as long patients remained in the program suggests that exposure to light, under a strict daily regimen, combined with controlled DART, actively slows or arrests the progressive degenerative process underlying PD.

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Metabolic Effects of Light at Night are Time‐ and Wavelength‐Dependent in Rats

Masís‐Vargas

Ritsema

Mendoza

et al. 2020

Obesity

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Objective Intrinsically photosensitive retinal ganglion cells are most sensitive to short wavelengths and reach brain regions that modulate biological rhythms and energy metabolism. The increased exposure nowadays to artificial light at night (ALAN), especially short wavelengths, perturbs our synchronization with the 24‐hour solar cycle. Here, the time‐ and wavelength dependence of the metabolic effects of ALAN are investigated. Methods Male Wistar rats were exposed to white, blue, or green light at different time points during the dark phase. Locomotor activity, energy expenditure, respiratory exchange ratio (RER), and food intake were recorded. Brains, livers, and blood were collected. Results All wavelengths decreased locomotor activity regardless of time of exposure, but changes in energy expenditure were dependent on the time of exposure. Blue and green light reduced RER at Zeitgeber time 16‐18 without changing food intake. Blue light increased period 1 ( Per1) gene expression in the liver, while green and white light increased Per2 . Blue light decreased plasma glucose and phosphoenolpyruvate carboxykinase ( Pepck) expression in the liver. All wavelengths increased c‐Fos activity in the suprachiasmatic nucleus, but blue and green light decreased c‐Fos activity in the paraventricular nucleus. Conclusions ALAN affects locomotor activity, energy expenditure, RER, hypothalamic c‐Fos expression, and expression of clock and metabolic genes in the liver depending on the time of day and wavelength.

show abstract

Light-induced activity in the activity box is not aversively motivated and does not show between-trial habituation

Cited by 13 publications

References 18 publications

Neuropharmacology of light-induced locomotor activation

Neuropharmacology of light-induced locomotor activation

A historical justification for and retrospective analysis of the systematic application of light therapy in Parkinson’s disease

Metabolic Effects of Light at Night are Time‐ and Wavelength‐Dependent in Rats

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