Light Exposure of the Lower Leg as a Pathogenetic Factor in the Occurrence of Malignant Melanoma

Bell, Mary; Beyl, C.M.; Schopf, R. E.; Schramm, Peter

doi:10.1159/000247463

Cited by 16 publications

(4 citation statements)

References 6 publications

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“…Although the lower extremities were the most frequent locations in women, this site demonstrated a lower percentage than those found in other series (2,4,8,14,25). These differences might be related to diverse forms of dressing (28). In the last few years, we have also observed an important increase in the presence of melanoma on the trunk region and a decrease in the lower extremities.…”

Section: Discussioncontrasting

confidence: 50%

Clinicopathological analysis of 1571 cutaneous malignant melanomas in Valencia, Spain: factors related to tumour thickness

Nagore¹,

Oliver²,

Botella‐Estrada³

et al. 2006

Acta Derm Venereol

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Epidemiological studies on cutaneous melanoma in Mediterranean countries are scarce. Our aim was to perform a descriptive analysis of melanoma cases diagnosed in Valencia, Spain, and to evaluate the relationship between Breslow thickness and some clinical features. A total of 1571 patients with histologically confirmed cutaneous malignant melanoma diagnosed at the two main referral melanoma centres were evaluated retrospectively. For each patient the following clinical and pathological characteristics were selected: age, gender, anatomic site, histogenetic type, Breslow thickness, presence of ulceration, the stage, and symptoms such as bleeding, changes in size and colour, altered sensations and previous traumas. Chi-squared tests were performed together with logistic regression to evaluate the relationship of variables with tumour thickness. Tumour thickness was independently correlated with increasing age, presence of bleeding, location on hand or foot, and presence of altered sensations. Female sex and presence of a change in colour were associated with thin melanomas. Ideally, public awareness campaigns concerning the risks that exist should be aimed at subgroups such as men and people of an advanced age who generally present with thicker tumours. Emphasis should be placed on irregularities or changes in pigmentation, as these appear to be the first indicators of the development of a melanoma.

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Section: Discussioncontrasting

confidence: 50%

Clinicopathological analysis of 1571 cutaneous malignant melanomas in Valencia, Spain: factors related to tumour thickness

Nagore¹,

Oliver²,

Botella‐Estrada³

et al. 2006

Acta Derm Venereol

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“…Therefore, for histopathologically equivocal lesions, clinical data such as patient age and sex/gender as stated by the patient or location of the lesion are usually attributed a greater weight within the decision-making algorithm. For example, a spitzoid melanocytic tumour in a young person warrants a more conservative management than a similar tumour in late adulthood [5]; a melanocytic tumour of the lower limb is more likely to be malignant in women than in men and the reverse is true for melanocytic tumours of the back [6].…”

Section: Introductionmentioning

confidence: 99%

Combining CNN-based histologic whole slide image analysis and patient data to improve skin cancer classification

Höhn

Krieghoff-Henning

Jutzi

et al. 2021

European Journal of Cancer

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Background: Clinicians and pathologists traditionally use patient data in addition to clinical examination to support their diagnoses. Objectives: We investigated whether a combination of histologic whole slides image (WSI) analysis based on convolutional neural networks (CNNs) and commonly available patient data (age, sex and anatomical site of the lesion) in a binary melanoma/nevus classification task could increase the performance compared with CNNs alone. Methods: We used 431 WSIs from two different laboratories and analysed the performance of classifiers that used the image or patient data individually or three common fusion techniques. Furthermore, we tested a naive combination of patient data and an image classifier: for cases interpreted as 'uncertain' (CNN output score <0.7), the decision of the CNN was replaced by the decision of the patient data classifier. Results: The CNN on its own achieved the best performance (mean AE standard deviation of five individual runs) with AUROC of 92.30% AE 0.23% and balanced accuracy of 83.17% AE 0.38%. While the classification performance was not significantly improved in general by any of the tested fusions, naive strategy of replacing the image classifier with the patient data classifier on slides with low output scores improved balanced accuracy to 86.72% AE 0.36%. Conclusion:In most cases, the CNN on its own was so accurate that patient data integration did not provide any benefit. However, incorporating patient data for lesions that were classified by the CNN with low 'confidence' improved balanced accuracy.

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“…[10][11][12][13] Some anatomic locations depict specific epidemiological features, such as a predominance of lentigo malignant melanoma and an older age at diagnosis in the head and neck. 14 These differences have been related to patterns of sun exposure, [15][16][17] or with a site dependent susceptibility of melanocytes. 18 Others have suggested the existence of different pathways that could be related with anatomic site.…”

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confidence: 99%

Cutaneous melanoma: hints from occupational risks by anatomic site in Swedish men

Pérez‐Gómez

2004

Occup Environ Med

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Aims: To improve knowledge of the epidemiology of melanoma by comparing occupational risks of cutaneous melanoma (CM) by anatomic site in Swedish workers. Methods: Male workers employed in 1970 and living in the country in 1960 were followed up from 1971 to 1989 using the Swedish Registers of Death and Cancer. A more specifically exposed subcohort included men reporting the same occupation in 1960 and 1970. For each location, occupational risk ratios (RRs) were extracted from Poisson regression models adjusted by age, period, town size, and geographical area. To diminish the influence of socioeconomic factors, intrasector analyses, comparing only jobs belonging to the same occupational sector, were performed. Risk patterns for different locations were compared. Results: High RRs for different sites were found among workers exposed to UV sources (dentists, physiotherapists, and lithographers), and sun exposed workers (harbour masters, and lighthouse/related work). Risk excesses were seen in fur tailors, tanners/fur dressers, patternmakers/cutters, electrical fitters/ wiremen, telephone/telegraph installers/repairmen, and some glass/pottery/tile workers. Results for lower and upper limbs were significantly correlated but somewhat independent of those found in thorax, the most frequent location. Correlation between head/neck and thorax was moderate. Specific risk excesses were found for rolling mill workers in head/neck, for chimney sweeps in upper limbs, and for aircraft pilots/navigators/flight engineers in lower limbs. Conclusions: High RRs in the trunk among occupations with UV exposure from artificial sources suggest an effect not restricted to exposed sites. An unusual distribution of cases and RRs in chimney sweeps, rollingmill, or glass/pottery/tile workers suggests local effects of exposures. The not previously reported risk excess in this job and in fur related processes, and the RR in electrical fitters and telephone/telegraph installers deserve further investigation. Disparities between locations, as RRs in thorax and limbs, may reflect differences in aetiological mechanisms.

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Light Exposure of the Lower Leg as a Pathogenetic Factor in the Occurrence of Malignant Melanoma

Cited by 16 publications

References 6 publications

Clinicopathological analysis of 1571 cutaneous malignant melanomas in Valencia, Spain: factors related to tumour thickness

Clinicopathological analysis of 1571 cutaneous malignant melanomas in Valencia, Spain: factors related to tumour thickness

Combining CNN-based histologic whole slide image analysis and patient data to improve skin cancer classification

Cutaneous melanoma: hints from occupational risks by anatomic site in Swedish men

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