Light enhanced the antimicrobial, anticancer, and catalytic activities of selenium nanoparticles fabricated by endophytic fungal strain, Penicillium crustosum EP-1

Abstract

Selenium nanoparticles (Se-NPs) has recently received great attention over owing to their superior optical properties and wide biological and biomedical applications. Herein, crystallographic and dispersed spherical Se-NPs were green synthesized using endophytic fungal strain, Penicillium crustosum EP-1. The antimicrobial, anticancer, and catalytic activities of biosynthesized Se-NPs were investigated under dark and light (using Halogen tungsten lamp, 100 Watt, λ > 420 nm, and light intensity of 2.87 W m−2) conditions. The effect of Se-NPs was dose dependent and higher activities against Gram-positive and Gram-negative bacteria as well different Candida spp. were attained in the presence of light than obtained under dark conditions. Moreover, the viabilities of two cancer cells (T47D and HepG2) were highly decreased from 95.8 ± 2.9% and 93.4 ± 3.2% in dark than those of 84.8 ± 2.9% and 46.4 ± 3.3% under light-irradiation conditions, respectively. Significant decreases in IC50 values of Se-NPs against T47D and HepG2 were obtained at 109.1 ± 3.8 and 70.4 ± 2.5 µg mL−1, respectively in dark conditions than 19.7 ± 7.2 and 4.8 ± 4.2 µg mL−1, respectively after exposure to light-irradiation. The photoluminescence activity of Se-NPs revealed methylene blue degradation efficiency of 89.1 ± 2.1% after 210 min under UV-irradiation compared to 59.7 ± 0.2% and 68.1 ± 1.03% in dark and light conditions, respectively. Moreover, superior stability and efficient MB degradation efficiency were successfully achieved for at least five cycles.

New thiadiazole modified chitosan derivative to control the growth of human pathogenic microbes and cancer cell lines

“…The current examination revealed that the MIC value of ciprofloxacin was 25 μg ml –1 against Gram-negative tested pathogens, while the MIC values of penicillin G and ketoconazole against Gram-positive and fungal pathogens, respectively, were perceived at 50 μg ml –1 . These findings are consistent with previous studies confirming that the elimination of fungal infections may require intensive doses, as they have a very solid cell wall containing chitin and glucan and is completely different from the bacterial cell wall 71 , 72 . Overall, it can be concluded that the antimicrobial activity of functionalized chitosan with thiadiazole derivative was increased compared to unmodified compound.…”

Myco-Nanofabrication of Silver Nanoparticles by Penicillium brasilianum NP5 and Their Antimicrobial, Photoprotective and Anticancer Effect on MDA-MB-231 Breast Cancer Cell Line

“…The elemental analysis of NP5-AgNPs exhibited a prominent silver peak at 3 keV, indicating that silver is the primary element in the fabricated AgNPs. The weaker peaks of carbon, oxygen, potassium, silicon and other recorded elements in the nanoparticles are due to fungal bioactive metabolites, such as proteins and enzymes, which cap and impart the stability of AgNPs [ 42 ]. Pallavi et al [ 43 ] also found that biosynthesized AgNPs from the Streptomyces hirsutus strain SNPGA-8, exhibit prominent silver peak at 3 keV with 22.24% silver in the synthesized NPs along with other trace elements.…”

Phytochemistry and Biological Activities of Endophytic Fungi from the Meliaceae Family

“…This activity provides antibiotics against pathogens and microorganisms such as C. gloeosporioides , E. coli , B. subtilis , S. aureus , and B. cereus that can cause food defects. Furthermore, antimicrobial is divided into antifungal and antibacterial [ 76 , 77 , 78 , 79 , 80 , 81 , 82 ]. Helvolic acid ( 4 ) was tested against fungi such as B. cinerea , A. solani , A. alternata (Fries) Keissler, C. gloeosporioides , F. solani , F. oxysporum f. sp.…”