Light energy transduction in liposome-based artificial cells

Albanese, Paola; Mavelli, Fabio; Altamura, Emiliano

doi:10.3389/fbioe.2023.1161730

Cited by 5 publications

(1 citation statement)

References 77 publications

(103 reference statements)

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“…SCs with smaller internal compartments are used as models of eukaryotic cells, or just to achieve specific and more complex behaviors [ 131 ]. Interested readers should refer to recent reviews, e.g., [ 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 , 149 ].…”

Section: Appendix A1 Pioneering Work On Bottom-up Synthetic Cellsmentioning

confidence: 99%

Chemical Systems for Wetware Artificial Life: Selected Perspectives in Synthetic Cell Research

Stano

2023

IJMS

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The recent and important advances in bottom-up synthetic biology (SB), in particular in the field of the so-called “synthetic cells” (SCs) (or “artificial cells”, or “protocells”), lead us to consider the role of wetware technologies in the “Sciences of Artificial”, where they constitute the third pillar, alongside the more well-known pillars hardware (robotics) and software (Artificial Intelligence, AI). In this article, it will be highlighted how wetware approaches can help to model life and cognition from a unique perspective, complementary to robotics and AI. It is suggested that, through SB, it is possible to explore novel forms of bio-inspired technologies and systems, in particular chemical AI. Furthermore, attention is paid to the concept of semantic information and its quantification, following the strategy recently introduced by Kolchinsky and Wolpert. Semantic information, in turn, is linked to the processes of generation of “meaning”, interpreted here through the lens of autonomy and cognition in artificial systems, emphasizing its role in chemical ones.

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Section: Appendix A1 Pioneering Work On Bottom-up Synthetic Cellsmentioning

confidence: 99%

Chemical Systems for Wetware Artificial Life: Selected Perspectives in Synthetic Cell Research

Stano

2023

IJMS

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Phospholipid Membranes as Chemically and Functionally Tunable Materials

Huster,

Maiti,

Herrmann

2024

Advanced Materials

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The sheet‐like lipid bilayer is the fundamental structural component of all cell membranes. Its building blocks are phospholipids and cholesterol. Their amphiphilic structure spontaneously leads to the formation of a bilayer in aqueous environment. Lipids are not just structural elements. Individual lipid species, the lipid membrane structure, and lipid dynamics influence and regulate membrane protein function. An exciting field is emerging where the membrane‐associated material properties of different bilayer systems are used in designing innovative solutions for widespread applications across various fields, such as the food industry, cosmetics, nano‐ and biomedicine, drug storage and delivery, biotechnology, nano‐ and biosensors, and computing. Here, the authors summarize what is known about how lipids determine the properties and functions of biological membranes and how this has been or can be translated into innovative applications. Based on recent progress in the understanding of membrane structure, dynamics, and physical properties, a perspective is provided on how membrane‐controlled regulation of protein functions can extend current applications and even offer new applications.

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Towards Synthetic Cells with Self‐Producing Energy

Hwang,

Kim,

Liu

2024

ChemPlusChem

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Autonomous generation of energy, specifically adenosine triphosphate (ATP), is critical for sustaining the engineered functionalities of synthetic cells constructed from the bottom‐up. In this mini‐review, we categorize studies on ATP‐producing synthetic cells into three different approaches: photosynthetic mechanisms, mitochondrial respiration mimicry, and utilization of non‐conventional approaches such as exploiting synthetic metabolic pathways. Within this framework, we evaluate the strengths and limitations of each approach and provide directions for future research endeavors. We also introduce a concept of building ATP‐generating synthetic organelle that will enable us to mimic cellular respiration in a simpler way than current strategies. This review aims to highlight the importance of energy self‐production in synthetic cells, providing suggestions and ideas that may help overcome some longstanding challenges in this field.

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Light energy transduction in liposome-based artificial cells

Cited by 5 publications

References 77 publications

Chemical Systems for Wetware Artificial Life: Selected Perspectives in Synthetic Cell Research

Chemical Systems for Wetware Artificial Life: Selected Perspectives in Synthetic Cell Research

Phospholipid Membranes as Chemically and Functionally Tunable Materials

Towards Synthetic Cells with Self‐Producing Energy

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