Light emitting fabric technologies for photodynamic therapy

Mordon, Serge; Cochrane, Cédric; Tylcz, Jean Baptiste; Betrouni, Nacim; Mortier, Laurent; Končar, Vladan

doi:10.1016/j.pdpdt.2014.11.002

Cited by 71 publications

(51 citation statements)

References 13 publications

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“…besides elimination of the neoplastic tissue, PDT treatment may also decrease the risk of esophageal stricture and perforation. Moreover, technological improvements (e.g., light emitting fabrics or optical fibers), enabled a rapid progress in the field of PDT (29). However, there is still a need for new and highly effective photosensitizers.…”

Section: Discussionmentioning

confidence: 99%

Novel zinc phthalocyanine as a promising photosensitizer for photodynamic treatment of esophageal cancer

Kuzyniak

Schmidt

Glac

et al. 2017

International Journal of Oncology

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Photodynamic therapy (PDT) has gathered much attention in the field of cancer treatment and is increasingly used as an alternative solution for esophageal cancer therapy. However, there is a constant need for improving the effectiveness and tolerability of the applied photosensitizers (PS). Here, we propose tetra-triethyleneoxysulfonyl substituted zinc phthalocyanine (ZnPc) as a promising PS for photodynamic treatment of esophageal cancer. ZnPc-induced phototoxicity was studied in two human esophageal cancer cell lines: OE-33 (adenocarcinoma) and Kyse-140 (squamous cell carcinoma). In vitro studies focused on the uptake and intracellular distribution of the novel ZnPc as well as on its growth inhibitory potential, reactive oxygen species (ROS) formation and the induction of apoptosis. The chicken chorioallantoic membrane assay (CAM assay) and studies on native Wistar rats were employed to determine the antineoplastic and antiangiogenic activity of ZnPc-PDT as well as the tolerability and safety of non-photoactivated ZnPc in vivo. ZnPc was taken up by cancer cells in a dose- and time-dependent manner and showed a homogeneous cytoplasmic distribution. Photoactivation of ZnPc-loaded (1-10 µM) cells led to a dose-dependent growth inhibition of esophageal adenocarcinoma and squamous cell carcinoma cells of >90%. The antiproliferative effect was based on ROS-induced cytotoxicity and the induction of mitochondria-driven apoptosis. In vivo studies on esophageal tumor plaques grown on the CAM revealed pronounced antiangiogenic and antineoplastic effects. ZnPc-PDT caused long-lasting changes in the vascular architecture and a marked reduction of tumor feeding blood vessels. Animal studies confirmed the good tolerability and systemic safety of ZnPc, as no changes in immunological, behavioral and organic parameters could be detected upon treatment with the non-photoactivated ZnPc. Our findings show the extraordinary photoactive potential of the novel ZnPc as a photosensitizer for PDT of esophageal cancer.

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Section: Discussionmentioning

confidence: 99%

Novel zinc phthalocyanine as a promising photosensitizer for photodynamic treatment of esophageal cancer

Kuzyniak

Schmidt

Glac

et al. 2017

International Journal of Oncology

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“…Organic LEDs are yet another more recent advance with advantages of flexibility [35]. In a similar vein, we have the recent introduction of light-emitting fabrics, which can be made into wearable light-emitting clothing, and is currently being used clinically for PDT of actinic keratoses on the scalp [36]. The advantages of these wearable light sources are as follows.…”

Section: Light Sources Optics and Dosimetrymentioning

confidence: 99%

Advances in antimicrobial photodynamic inactivation at the nanoscale

2017

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The alarming worldwide increase in antibiotic resistance amongst microbial pathogens necessitates a search for new antimicrobial techniques, which will not be affected by, or indeed cause resistance themselves. Light-mediated photoinactivation is one such technique that takes advantage of the whole spectrum of light to destroy a broad spectrum of pathogens. Many of these photoinactivation techniques rely on the participation of a diverse range of nanoparticles and nanostructures that have dimensions very similar to the wavelength of light. Photodynamic inactivation relies on the photochemical production of singlet oxygen from photosensitizing dyes (type II pathway) that can benefit remarkably from formulation in nanoparticle-based drug delivery vehicles. Fullerenes are a closed-cage carbon allotrope nanoparticle with a high absorption coefficient and triplet yield. Their photochemistry is highly dependent on microenvironment, and can be type II in organic solvents and type I (hydroxyl radicals) in a biological milieu. Titanium dioxide nanoparticles act as a large band-gap semiconductor that can carry out photo-induced electron transfer under ultraviolet A light and can also produce reactive oxygen species that kill microbial cells. We discuss some recent studies in which quite remarkable potentiation of microbial killing (up to six logs) can be obtained by the addition of simple inorganic salts such as the non-toxic sodium/potassium iodide, bromide, nitrite, and even the toxic sodium azide. Interesting mechanistic insights were obtained to explain this increased killing.

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“…Optical fiber (OF) has a flexible structure featuring cladding and a core, which allows laser diffusion over a tortuous route because of multiple reflections within the fiber [134]. Moreover, the minor diameter of OFs facilitates puncturing through the skin and subcutaneous tissues with minimal invasion and reaching tumor tissues in deep tissue.…”

Section: Novel Strategies In Pdt Of Osmentioning

confidence: 99%

A review and outlook in the treatment of osteosarcoma and other deep tumors with photodynamic therapy: from basic to deep

Zhu

Wang

et al. 2017

Oncotarget

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Photodynamic therapy, one of the most promising minimally invasive treatments, has received increasing focus in tumor therapy research, which has been widely applied in treating superficial tumors. Three basic factors - photosensitizer, the light source, and oxidative stress - are responsible for tumor cell cytotoxicity. However, due to insufficient luminous flux and peripheral tissue damage, the utilization of photodynamic therapy is facing a huge limitation in deep tumor therapy. Osteosarcoma is the typical deep tumor, which is the most commonly occurring malignancy in children and adolescents. Despite developments in surgery, high risks of the amputation still threatens the health of osteosarcoma patients. In this review, we summarize recent developments in the field of photodynamic therapy and specifically PDT research in OS treatment modalities. In addition, we also provide some novel suggestions, which could potentially be a breakthrough in PDT-induced OS therapies. PDT has the potential to become an effective therapy while the its limitations still present when applied on the treatment of OS or other types of deep tumors. Thus, more researches and studies in the field are required.

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Light emitting fabric technologies for photodynamic therapy

Cited by 71 publications

References 13 publications

Novel zinc phthalocyanine as a promising photosensitizer for photodynamic treatment of esophageal cancer

Novel zinc phthalocyanine as a promising photosensitizer for photodynamic treatment of esophageal cancer

Advances in antimicrobial photodynamic inactivation at the nanoscale

A review and outlook in the treatment of osteosarcoma and other deep tumors with photodynamic therapy: from basic to deep

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