Light-driven fine chemical production in yeast biohybrids

Guo, Junling; Suástegui, Miguel; Sakimoto, Kelsey K.; Moody, Vanessa M.; Xiao, Gao; Nocera, Daniel G.; Joshi, Neel

doi:10.1126/science.aat9777

Cited by 272 publications

(260 citation statements)

References 35 publications

Supporting

Mentioning

256

Contrasting

Order By: Relevance

“…on July 4, 2020 http://advances.sciencemag.org/ Downloaded from Another nanobiohybrid system was recently reported by interfacing efficient light-harvesting InP nanoparticles and genetically engineered Saccharomyces cerevisiae (34). The photoexcited electrons produced from InP activate reduced form of nicotinamide adenine dinucleotide phosphate regeneration, fueling the ultimate conversion of 3-dehydroshikimic acid to shikimic acid by the hybrid cells.…”

Section: Exogenous Bioaugmentationmentioning

confidence: 99%

Nanobiohybrids: Materials approaches for bioaugmentation

et al. 2020

View full text Add to dashboard Cite

Nanobiohybrids, synthesized by integrating functional nanomaterials with living systems, have emerged as an exciting branch of research at the interface of materials engineering and biological science. Nanobiohybrids use synthetic nanomaterials to impart organisms with emergent properties outside their scope of evolution. Consequently, they endow new or augmented properties that are either innate or exogenous, such as enhanced tolerance against stress, programmed metabolism and proliferation, artificial photosynthesis, or conductivity. Advances in new materials design and processing technologies made it possible to tailor the physicochemical properties of the nanomaterials coupled with the biological systems. To date, many different types of nanomaterials have been integrated with various biological systems from simple biomolecules to complex multicellular organisms. Here, we provide a critical overview of recent developments of nanobiohybrids that enable new or augmented biological functions that show promise in high-tech applications across many disciplines, including energy harvesting, biocatalysis, biosensing, medicine, and robotics.

show abstract

Section: Exogenous Bioaugmentationmentioning

confidence: 99%

Nanobiohybrids: Materials approaches for bioaugmentation

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Taking light harvesting to the next level, Guo et al () described a novel inorganic‐biological hybrid system that utilizes the light‐harvesting properties of semiconductors to drive the reduction of cellular NADP + in yeast. The production of desired products by fermentation requires that some carbon from the feedstock be diverted to maintain the redox balance through regeneration of the cellular reductant NADPH (the reduced form of NADP + ).…”

Section: Synthetic Biology Harnesses the Awesome Power Of Lightmentioning

confidence: 99%

The renaissance of yeasts as microbial factories in the modern age of biomanufacturing

Payen

Thompson

2019

Yeast

View full text Add to dashboard Cite

Yeasts are essential for many processes, including the production of some of our most beloved foods and beverages. Less is known to the public about the far‐reaching impacts of yeasts on other products such as biofuels, pharmaceuticals, and industrial products. By leveraging and combining newly discovered yeast genetic diversity with now affordable and efficient genetic engineering and synthetic biology tools, academic and industrial yeast labs have designed yeast cell factories for a wide range of novel applications such as the production of medicines, components of human breast milk, heme for meat substitutes, bioplastics, and other biomaterials. This review covers the newest technologies developed for yeast research including synthetic biology and their use in the engineering of yeast cell factories for emerging applications.

show abstract

“…Getting to this level with industrially scalable synthetic systems is no doubt an enormous but exciting challenge for science. [ 12 ] This review will cover selective examples of supramolecular energy materials investigated so far, in which functionality is generated designing noncovalent interactions among molecules.…”

Section: Introductionmentioning

confidence: 99%

Supramolecular Energy Materials

et al. 2020

View full text Add to dashboard Cite

Self‐assembly is a bioinspired strategy to craft materials for renewable and clean energy technologies. In plants, the alignment and assembly of the light‐harvesting protein machinery in the green leaf optimize the ability to efficiently convert light from the sun to form chemical bonds. In artificial systems, strategies based on self‐assembly using noncovalent interactions offer the possibility to mimic this functional correlation among molecules to optimize photocatalysis, photovoltaics, and energy storage. One of the long‐term objectives of the field described here as supramolecular energy materials is to learn how to design soft materials containing light‐harvesting assemblies and catalysts to generate fuels and useful chemicals. Supramolecular energy materials also hold great potential in the design of systems for photovoltaics in which intermolecular interactions in self‐assembled structures, for example, in electron donor and acceptor phases, maximize charge transport and avoid exciton recombination. Possible pathways to integrate organic and inorganic structures by templating strategies and electrodeposition to create materials relevant to energy challenges including photoconductors and supercapacitors are also described. The final topic discussed is the synthesis of hybrid perovskites in which organic molecules are used to modify both structure and functions, which may include chemical stability, photovoltaics, and light emission.

show abstract

Light-driven fine chemical production in yeast biohybrids

Cited by 272 publications

References 35 publications

Nanobiohybrids: Materials approaches for bioaugmentation

Nanobiohybrids: Materials approaches for bioaugmentation

The renaissance of yeasts as microbial factories in the modern age of biomanufacturing

Supramolecular Energy Materials

Contact Info

Product

Resources

About