Light‐Controlled [3]Pseudorotaxane Based on Tetrasulfonated 1,5‐Dinaphtho‐32‐Crown‐8 and α‐Cyclodextrin

Wang, Jun; Zhang, Ying‐Ming; Zhang, Xu-Jie; Zhao, Xiaojun; Liu, Yu

doi:10.1002/ajoc.201402238

Cited by 6 publications

(3 citation statements)

References 59 publications

(15 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1 ), the system may reversely accept and release CDs in solution upon application of an appropriate stimulus. While CDs are known to be the host in almost all cases, reports on their use as guest are rare 26 . Therefore, the present system is a rare example where CDs behave as the guest in a host–guest molecular interaction.…”

Section: Introductionmentioning

confidence: 99%

Stepwise control of host–guest interaction using a coordination polymer gel

2018

View full text Add to dashboard Cite

Precise control of host–guest interaction as seen in biological processes is difficult to achieve with artificial systems. Herein we have exploited the thermodynamic benefits of a system in equilibrium to achieve controlled stepwise release and capture of cyclodextrin (guest) using a coordination polymer (Mg-CP) as the host and temperature as the stimulus. Since temperature is not a precision stimulus for artificial host–guest interaction, the present system is a distinct prototype that manifests temperature-controlled natural host–guest interaction. The described coordination polymeric host system, when incorporated into a hydrogel matrix, provides a microenvironment that facilitates the stepwise release of α-CD in response to temperature variation within a quasi-solid state. The work demonstrated here may pave the way towards thermally controlled delivery and monitoring of otherwise spectroscopically silent molecules such as cyclodextrins.

show abstract

Section: Introductionmentioning

confidence: 99%

Stepwise control of host–guest interaction using a coordination polymer gel

2018

View full text Add to dashboard Cite

show abstract

“…For these reasons, CDs are widely used in the pharmaceutical and health care sectors for the delivery of active principles. − The presence of several hydroxyl groups with different reactivities allows to functionalize the CD cone in a selective way and to modify the physicochemical properties of the final derivative for applications . Considering also the possibility to build complex supramolecular architectures, − the applications of CDs nowadays span from the design of molecular machines to the development of nanovectors for cancer treatment and gene delivery. − With specific reference to medical diagnostics, CDs are, for the same reasons, also promising candidates for the synthesis of advanced contrast agents for MRI. − …”

Section: Introductionmentioning

confidence: 99%

Dynamic Nuclear Polarization of β-Cyclodextrin Macromolecules

et al. 2017

View full text Add to dashboard Cite

H dynamic nuclear polarization and nuclear spin-lattice relaxation rates have been studied in amorphous complexes of β-cyclodextrins doped with different concentrations of the TEMPO radical. Nuclear polarization increased up to 10% in the optimal case, with a behavior of the buildup rate (1/T) and of the nuclear spin-lattice relaxation rate (1/T) consistent with a thermal mixing regime. The temperature dependence of 1/T and its increase with the radical concentration indicate a relaxation process arising from the modulation of the electron-nucleus coupling by the glassy dynamics. The high-temperature relaxation is driven by molecular motions, and 1/T was studied at room temperature in liquid solutions for dilution levels close to the ones typically used for in vivo studies.

show abstract

“…Moreover, owing to their cone-shaped structure and chemical versatility, they can form inclusion complexes with several molecules and are widely used in the pharmaceutical and health sectors for the delivery of active principles . Accordingly, their applications nowadays span from the development of nanovectors for cancer treatment and for gene delivery to the development of contrast agents. − Hence, the possibility to perform DNP on β-CD would allow to follow through in vivo molecular imaging the fate of the drug hosted by the CDs. In previous works, , we managed to raise 1 H and 13 C nuclear polarizations up to 10 and 7%, respectively.…”

Section: Introductionmentioning

confidence: 99%

Molecular Dynamics and Hyperpolarization Performance of Deuterated β-Cyclodextrins

et al. 2019

View full text Add to dashboard Cite

We discuss the temperature dependence of the 1H and 13C nuclear spin–lattice relaxation rate 1/T 1 and dynamic nuclear polarization (DNP) performance in β-cyclodextrins with deuterated methyl groups. It is shown that 13C DNP-enhanced polarization is raised up to 10%. The temperature dependence of the buildup rate for nuclear spin polarization and of 1/T 1, below 4.2 K, is analyzed in the framework of the thermal mixing regime and the origin of the deviations from the theoretical behavior discussed. 13C 1/T 1 is determined at low temperature by the glassy dynamics and at high temperature by the rotational molecular motions of the deuterated methyl groups. Thanks to deuteration, relaxation times approaching 30 s are achieved at room temperature, making this material interesting for molecular imaging applications. The effect of molecular dynamics on the line width of the NMR spectra is also discussed.

show abstract

Light‐Controlled [3]Pseudorotaxane Based on Tetrasulfonated 1,5‐Dinaphtho‐32‐Crown‐8 and α‐Cyclodextrin

Cited by 6 publications

References 59 publications

Stepwise control of host–guest interaction using a coordination polymer gel

Stepwise control of host–guest interaction using a coordination polymer gel

Dynamic Nuclear Polarization of β-Cyclodextrin Macromolecules

Molecular Dynamics and Hyperpolarization Performance of Deuterated β-Cyclodextrins

Contact Info

Product

Resources

About