It has been conjectured that the classical dynamics of M-theory is equivalent to a null geodesic motion in the infinite-dimensional coset space E 10 /K(E 10 ), where K(E 10 ) is the maximal compact subgroup of the hyperbolic Kac-Moody group E 10 . We here provide further evidence for this conjecture by showing that the leading higher-order corrections, quartic in the curvature and related 3-form-dependent terms, correspond to negative imaginary roots of E 10 . The conjecture entails certain predictions for which higher-order corrections are allowed: in particular corrections of type R M (DF ) N are compatible with E 10 only for M +N = 3k+1. Furthermore, the leading parts of the R 4 , R 7 , . . . terms are predicted to be associated with singlets under the sl 10 decomposition of E 10 . Although singlets are extremely rare among the 4400 752 653 representations of sl 10 appearing in E 10 up to level 28, there are indeed singlets at levels = 10 and = 20 which do match with the R 4 and the expected R 7 corrections. Our analysis indicates a far more complicated behaviour of the theory near the cosmological singularity than suggested by the standard homogeneous ansätze.