“…The first group is characterized by a persistently elevated cold haemagglutinin titre and is typically represented by the cold haemagglutinin syndrome which is a rare, chronic disease characterized by very high titres of cold haemagglutinins, haemolytic anaemia, varying degrees of cold haemoglobinuria, and severe Raynaud phenomena in the cold. The cold haemagglutinins occurring in this disease have been identified as 'monoclonal' I,M-globulins, mainly in cases with high concentrations of cold haemagglutinin protein (Christenson & Dacie 1957, Christenson et al 1957, Fudenberg & Kunkel 1957, Mehrotra 1960a, Lind 1963, Harboe & Deverill 1964, Harboe & Lind 1966.…”