Light Chain Amyloidosis: A Case Presentation and Review

Melmed, Gavin M.

doi:10.1080/08998280.2009.11928533

Cited by 3 publications

(2 citation statements)

References 22 publications

(18 reference statements)

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“…Moreover, the electrophoretic separation of serum proteins is very important in the differentiation of monoclonal gammopathies from polyclonal gammopathies. For gastroenterologists, the method may be of special interest in the diagnosis of chronic liver diseases, hepatic cirrhosis, hepatocellular carcinoma, α 1 -antitrypsin deficiency, inflammatory bowel disease, or amyloidosis, in which clinical signs and symptoms may be seen in the whole gastrointestinal tract (Melmed 2009). In small animals, protein electrophoresis is commonly used to support a clinical diagnosis of diseases characterised by dysproteinaemia (leishmaniasis, ehrlichiosis, feline infectious peritonitis), or to identify the presence of inflammation with increased α-globulins.…”

Section: The Usefulness Of Serum Protein Electrophoresis In Clinical mentioning

confidence: 99%

Serum proteins and their diagnostic utility in veterinary medicine: a review

Tóthová¹,

Nagy²,

Kováč³

2016

Vet. Med.

130

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ABSTRACT:The evaluation of serum proteins and their electrophoretic pattern is a well-established laboratory method in the diagnosis of many diseases in humans, which has replaced the biochemical determination of the concentrations of albumin and the ratio of albumin to globulins. The measurement of serum proteins may be an important diagnostic tool for the detection, diagnosis, and monitoring of various diseases and pathological processes. The results of serum protein electrophoresis can be one of the most useful diagnostic aids in a wide spectrum of diseases, including infectious and inflammatory diseases, renal or gastrointestinal disorders, immunodeficiency states, as well as paraproteinaemias caused by lymphoid or plasma cell neoplasia. Although many studies have been carried out to determine the usefulness of the determination of serum proteins and their electrophoretic pattern in various disease conditions and disorders also in animals, serum protein evaluation is still a relatively little-used diagnostic tool in veterinary medicine. In this article, methods of serum protein determination, their diagnostic utility in animal care practice and their different patterns in dysproteinaemias and paraproteinaemias are reviewed.

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Section: The Usefulness Of Serum Protein Electrophoresis In Clinical mentioning

confidence: 99%

Serum proteins and their diagnostic utility in veterinary medicine: a review

Tóthová¹,

Nagy²,

Kováč³

2016

Vet. Med.

130

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“…Laboratory tests such as serum protein electrophoresis with immunofixation, urine protein electrophoresis with immunofixation, and serum-free light chain assays should be performed. These studies may help to suggest the diagnosis, but confirmation must be obtained through a biopsy of an affected organ [ 7 ]. The gold standard of testing is polarizing microscopy, which visualizes "apple-green birefringence" of tissue and/or bone marrow biopsy via Congo red stain [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Need for Early Recognition of Amyloidosis in Cases of Unexplained Heart Failure: A Case Report

Kalluri¹,

Abbasi²

2023

Cureus

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Amyloidosis is a plasma cell dyscrasia that leads to the excessive production and deposition of mutant protein fragments in various organs. Cardiac amyloidosis is often implicated in two main subtypes: transthyretin (ATTR) and light chain (AL). While both subtypes increase the risk of restrictive cardiomyopathy, cardiogenic shock, and arrhythmias, poorer outcomes are seen in those with cardiac infiltration secondary to AL amyloidosis. Prognosis depends on the timing of diagnosis and the extent of the disease burden prior to recognition and treatment. The following case report describes a young patient who was admitted to the intensive care unit (ICU) for concerns of decompensated heart failure of unknown etiology, later determined to be due to amyloidosis. We describe her clinical course prior to and during hospital admission, along with the proposed physiologic factors that may have contributed to her poor outcome.

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