Light-based technologies for management of COVID-19 pandemic crisis

Sabino, Caetano P.; Ball, Anthony R.; Baptista, Maurício S.; Dai, Tianhong; Hamblin, Michael R.; Ribeiro, Martha S.; Santos, Ana Paula Pires dos; Sellera, Fábio P.; Tegos, George P.; Wainwright, Mark

doi:10.1016/j.jphotobiol.2020.111999

Cited by 70 publications

(66 citation statements)

References 119 publications

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“…Many photosensitizers (PSs) involved in photodynamic reactions can cause effective damage to the enveloped viruses, and therefore, PSs are considered promising agents to combat with SARS-CoV-2 [ 8 , 9 ]. However, a limited number of experimental studies used PSs to inactivate coronaviruses.…”

Section: Introductionmentioning

confidence: 99%

The Photosensitizer Octakis(cholinyl)zinc Phthalocyanine with Ability to Bind to a Model Spike Protein Leads to a Loss of SARS-CoV-2 Infectivity In Vitro When Exposed to Far-Red LED

Sharshov

Соломатина

Kurskaya

et al. 2021

Viruses

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Photodynamic inactivation of pathogenic microorganisms can be successfully used to eradicate pathogens in localized lesions, infected liquid media, and on various surfaces. This technique utilizes the photosensitizer (PS), light, and molecular oxygen to produce reactive oxygen species that kill pathogens. Here, we used the PS, water soluble octakis(cholinyl)zinc phthalocyanine (Zn-PcChol8+), to inactivate an initial 4.75–5.00 IgTCID50/mL titer of SARS-CoV-2, thereby preventing viral infection when tested in Vero E6 cell cultures. Zn-PcChol8+ in a minimally studied concentration, 1 µM and LED 3.75 J/cm2, completely destroyed the infectivity of SARS-CoV-2. To detect possible PS binding sites on the envelope of SARS-CoV-2, we analyzed electrostatic potential and simulated binding of Zn-PcChol8+ to the spike protein of this coronavirus by means of Brownian dynamics software, ProKSim (Protein Kinetics Simulator). Most of the Zn-PcChol8+ molecules formed clusters at the upper half of the stalk within a vast area of negative electrostatic potential. Positioning of the PS on the surface of the spike protein at a distance of no more than 10 nm from the viral membrane may be favorable for the oxidative damage. The high sensitivity of SARS-CoV-2 to photodynamic inactivation by Zn-PcChol8+ is discussed with respect to the application of this PS to control the spread of COVID-19.

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Section: Introductionmentioning

confidence: 99%

The Photosensitizer Octakis(cholinyl)zinc Phthalocyanine with Ability to Bind to a Model Spike Protein Leads to a Loss of SARS-CoV-2 Infectivity In Vitro When Exposed to Far-Red LED

Sharshov

Соломатина

Kurskaya

et al. 2021

Viruses

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“…To provide this update, a literature search was conducted on PubMed (until 18th November 2020) in which the following keywords were combined: (COVID-19 OR social distancing) AND (season, latitude, ultraviolet, sun exposure, sunlight, solar, phototherapy, vitamin D OR nitric oxide). While we focus on UV light and sun exposure, there may also be effects of other wavelengths within the solar spectrum, including violet/blue (400–700 nm), red (600–700 nm), and infrared (700–1,000 nm) light on COVID-19 ( 11 ) as well as preventative and therapeutic possibilities for other light-based therapies ( 12 ).…”

Section: Introductionmentioning

confidence: 99%

Investigating the Potential for Ultraviolet Light to Modulate Morbidity and Mortality From COVID-19: A Narrative Review and Update

Gorman

Weller

2020

Front. Cardiovasc. Med.

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During the COVID-19 (coronavirus disease of 2019) pandemic, researchers have been seeking low-cost and accessible means of providing protection from its harms, particularly for at-risk individuals such as those with cardiovascular disease, diabetes and obesity. One possible way is via safe sun exposure, and/or dietary supplementation with induced beneficial mediators (e.g., vitamin D). In this narrative review, we provide rationale and updated evidence on the potential benefits and harms of sun exposure and ultraviolet (UV) light that may impact COVID-19. We review recent studies that provide new evidence for any benefits (or otherwise) of UV light, sun exposure, and the induced mediators, vitamin D and nitric oxide, and their potential to modulate morbidity and mortality induced by infection with SARS-CoV-2 (severe acute respiratory disease coronavirus-2). We identified substantial interest in this research area, with many commentaries and reviews already published; however, most of these have focused on vitamin D, with less consideration of UV light (or sun exposure) or other mediators such as nitric oxide. Data collected to-date suggest that ambient levels of both UVA and UVB may be beneficial for reducing severity or mortality due to COVID-19, with some inconsistent findings. Currently unresolved are the nature of the associations between blood 25-hydroxyvitamin D and COVID-19 measures, with more prospective data needed that better consider lifestyle factors, such as physical activity and personal sun exposure levels. Another short-coming has been a lack of measurement of sun exposure, and its potential to influence COVID-19 outcomes. We also discuss possible mechanisms by which sun exposure, UV light and induced mediators could affect COVID-19 morbidity and mortality, by focusing on likely effects on viral pathogenesis, immunity and inflammation, and potential cardiometabolic protective mechanisms. Finally, we explore potential issues including the impacts of exposure to high dose UV radiation on COVID-19 and vaccination, and effective and safe doses for vitamin D supplementation.

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“…Ähnlich auch die Kommentare von Sabino u. Mitarb. [ 13 ]. Sie berichten, dass lichtbasierte Technologien ein nachweislich breites Wirkungsspektrum aufweisen und zeigen lichtbasierte Strategien zur Bekämpfung der COVID-19-Pandemie auf.…”

Section: Diskussion Und Zukunftsaspekteunclassified

Photobiomodulation und COVID-19

Litscher

2021

Akupunkt Aurikulomed

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Die Zahl hochrangiger Publikationen zur Photobiomodulation steigt weltweit überproportional an und es ist daher auch leicht nachvollziehbar, dass die Therapieoption auch bei der Behandlung von COVID-19 als komplementäres Verfahren zur Pandemiebekämpfung methodisch erweitert und getestet werden soll. Um den gegenwärtigen Stand des Wissens zur Thematik zu erheben, wurde eine aktuelle Recherche zu klinischen laufenden Forschungsprojekten und den ersten vorliegenden Ergebnissen initiiert. Seitens der gewählten Methode wurde dabei die Variante einer möglichen selbst durchführbaren „Heim-Behandlung“ in den Fokus der Recherche gestellt. Drei aktuelle Studiendesigns sollen in diesem Übersichtsreport näher beschrieben und diskutiert werden. Die drei beschriebenen Studienvorhaben entsprechen zwar nicht alle den seitens einer „good scientific practice“ notwendigen Anforderungen, sollen aber dennoch aufgrund der Aktualität hier kurz vorgestellt werden. Wenngleich die Designs durchaus wissenschaftlich beurteilbare Ergebnisse erwarten lassen, kann derzeit (noch) kein wissenschaftlicher Schluss gezogen werden, dass sich die drei Verfahren zur Behandlung von COVID-19 als geeignet erweisen. Gründe dafür sind, dass bei zwei der drei Studien noch keine Ergebnisse vorliegen und eine Pilotstudie grobe formale wissenschaftliche Mängel aufweist, die es gilt, in Folgeuntersuchungen zu vermeiden.

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Light-based technologies for management of COVID-19 pandemic crisis

Cited by 70 publications

References 119 publications

The Photosensitizer Octakis(cholinyl)zinc Phthalocyanine with Ability to Bind to a Model Spike Protein Leads to a Loss of SARS-CoV-2 Infectivity In Vitro When Exposed to Far-Red LED

The Photosensitizer Octakis(cholinyl)zinc Phthalocyanine with Ability to Bind to a Model Spike Protein Leads to a Loss of SARS-CoV-2 Infectivity In Vitro When Exposed to Far-Red LED

Investigating the Potential for Ultraviolet Light to Modulate Morbidity and Mortality From COVID-19: A Narrative Review and Update

Photobiomodulation und COVID-19

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