Light-Based Devices for the Treatment of Facial Erythema and Telangiectasia

Yepuri, Vani; Patil, Anant; Fritz, Klaus; Sălăvăstru, Carmen; Kroumpouzos, George; Nisticò, Steven Paul; Piccolo, Domenico; Ahmed, Sadek; Badawi, Ashraf; Kassir, Martin; Gold, Michael H.; Große-Büning, Stephan; Grabbe, Stephan; Goldust, Mohamad

doi:10.1007/s13555-021-00607-8

Cited by 14 publications

(11 citation statements)

References 48 publications

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“…2,3 In the field of dermatology, 595 nm PDL is now the gold standard to treat congenital and acquired vascular skin conditions such as port-wine stain, residual telangiectasia infantile haemangioma, Morbus Osler Rendu syndrome, telangiectatic rosacea and erythematous scars. [4][5][6][7] The biophysical principle of the PDL is selective photothermolysis. 8 The laser light of the PDL with the wavelength 595 nm is absorbed selectively by oxyhaemoglobin and is then converted to heat, which causes heat damage to the vessel wall and consequently vessel wall necrosis.…”

Section: E230 |mentioning

confidence: 99%

Pulsed dye laser for facial erythema in Netherton syndrome

Smets,

Gutermuth,

Grosber

et al. 2023

Acad Dermatol Venereol

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Dear Editor, Netherton syndrome (NS) is a rare autosomal recessive disorder characterized by a triad of atopic diathesis, ichthyosis linearis circumflexa (ILC) and hair shaft abnormalities. It is caused by pathogenic variants in the SPINK5 gene, also known as LEKTI (lympho-epithelial Kazal-type 5 related inhibitor). Currently, no cure or satisfactory treatments are available for NS. 1 A 34-year-old male patient with NS presented with persistent facial erythema. This manifestation of NS had the most important impact on our patient's emotional well-being in adult life, leading to embarrassment and lowered self-esteem. Skin examination revealed serpiginous erythematous plaques with double-edge circumferential scales on the arms and trunk, diagnosed as ichthyosis linearis circumflexa. In 2006, genetic testing revealed a mutation in the SPINK5 gene.Previous treatment with topical 0.33% brimonidine gel on the whole face resulted in a partial resolution of the redness for only 5 h. Topical corticosteroids/calcineurin inhibitors and skin moisturizers were used on the trunk, with good effect. He also participated in a clinical trial, where the protease inhibitor LEKTI cream was applied on the trunk, without any improvement of erythema.Due to the significant impact of facial erythema on our patient's quality of life, he consented to pulsed dye laser (PDL) treatment. PDL was performed on the entire face, and improvement of erythema was already observed after the first session Figure 1. The treatment was performed with the lowest purpuragenic fluence according to individual response. Post laser purpura and facial swelling disappeared after 2 weeks. A 595 nm Candela PDL system (Vbeam Perfecta, Syneron Candela Corporation) was used. Previous to treatment of the whole face, an initial test spot with a fluence of 15.5 J/cm 2 , 7 mm spot size and a pulse width of 20 ms were used.Based on the biological response of the test area, the fluence was adjusted up or down. In the consecutive treatments, the following laser settings were used: The spot size varied between 5 and 7 mm, the pulse width varied between 10 and 20 ms and the fluence varied between 6.5 and 17 J/ cm 2 . Treatment fluence was selected to induce faint transient purpura at the purpura threshold. Non-contact cooling was provided by the dynamic cooling device (DCD), 30/20 ms, to minimize epidermal damage. Laser pulses were overlapped by approximately 10% to have a uniform result.We performed initially three PDL treatments with good response. Treatment intervals were 3-8 months. The patient reported a marked improvement on his quality of life due to reduced facial erythema, especially during physical exercise. Since the facial erythema gradually recurred after 3 years, we performed two additional PDL sessions with an interval of 2 months (Figure 2).

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Section: E230 |mentioning

confidence: 99%

Pulsed dye laser for facial erythema in Netherton syndrome

Smets,

Gutermuth,

Grosber

et al. 2023

Acad Dermatol Venereol

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“…Lasers emitting in the so called yellow-range, which covers the 560-590 nm window, find use in applications such as astronomy [1] and biomedicine [2]- [7]. In the latter sector, the interest is increasing due to a proven positive impact of 577 nm radiation in the treatment of dermatologic and ophthalmologic conditions such as facial erythema and telangiectasia [2] or corneal neovascularization [3]. Indeed, owing to a high photo-absorption at 577 nm wavelength by both oxygenated and reduced hemoglobin, targeting blood vessels with yellow laser light is highly efficient.…”

Section: Introductionmentioning

confidence: 99%

Yellow laser based on the inhibited-coupling hollow-core photonic crystal fibre technology

Popenda,

Delahaye,

Amrani

et al. 2024

Nonlinear Frequency Generation and Conversion: Materials and Devices XXIII

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We report on a Raman laser emitting in the yellow spectral range using a CO2-filled hollow-core photonic crystal fiber. Taking advantage of a state-of-art inhibited-coupling hollow-core photonic crystal fibre, exhibiting minimum transmission loss of ~1 dB/km in the 500-600 nm region, we were able to develop an extremely compact and simple yellow-Raman laser scheme, allowing to emit as much as 60 mW of average power at the 574.5 nm wavelength while using a compact, microchip laser as a pump source. This solution provides an innovative and scalable alternative for the other yellow laser schemes, which are of high demand in the field of biophotonics due to their effective interaction with hemoglobin and melanin.

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“…Indeed, several lasers, most notably the flashlamp-pulsed dye laser, have been clinically shown to be beneficial for treating facial vascular lesions. Nonetheless, individuals have expressed concern about post-treatment adverse effects such as severe purpura and changes in pigmentation [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Effective Treatment of Rosacea and Other Vascular Lesions Using Intense Pulsed Light System Emitting Vascular Chromophore-Specific Wavelengths: A Clinical and Dermoscopical Analysis

Piccolo,

Fusco,

Zingoni

et al. 2024

JCM

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Background: Facial telangiectasias is a prevalent cosmetic disorder that can be associated with several conditions such as rosacea. IPL (intensity pulsed light) therapy is commonly used for the treatment of vascular lesions. This study tested the efficacy of an IPL system emitting selected vascular chromophore-specific wavelengths in the range of 500–1200 nm for the treatment of vascular lesions. Materials and Methods: A total of 39 patients affected by different vascular lesions on their face were enrolled. The procedure consisted of three treatment sessions, spaced 1 month apart, using the IPL system with a 500–677 and 854–1200 nm filter. Follow-up was performed at 21–90 days (3 weeks–3 months) after the last IPL session. Three-dimensional and dermoscopic clinical photographs were captured and evaluated using a five-point scale. Adverse events were checked. Results: In total, 21 patients achieved excellent improvement, 13 patients achieved good improvement, 3 patients achieved moderate improvement, 2 patients achieved mild improvement, and 0 patients achieved no improvement, with an overall good response to treatment. The photographic evaluation showed good results as soon as 3 days after the last IPL session. Relevant side effects were absent. Conclusions: The study device may represent a successful treatment to improve vascular lesions that are resistant to laser therapy.

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Light-Based Devices for the Treatment of Facial Erythema and Telangiectasia

Cited by 14 publications

References 48 publications

Pulsed dye laser for facial erythema in Netherton syndrome

Pulsed dye laser for facial erythema in Netherton syndrome

Yellow laser based on the inhibited-coupling hollow-core photonic crystal fibre technology

Effective Treatment of Rosacea and Other Vascular Lesions Using Intense Pulsed Light System Emitting Vascular Chromophore-Specific Wavelengths: A Clinical and Dermoscopical Analysis

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