Light and ocular immunity

Hajrasouliha, Amir Reza; Kaplan, Henry J.

doi:10.1097/aci.0b013e328357d3a4

Cited by 11 publications

(11 citation statements)

References 75 publications

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“…31 Furthermore, vitamin D can suppress IL-1β-induced IL-8 production in human whole blood. 34 As an oxidative protein modification, when elevated in the BM of AMD, CEP could stimulate neovascularization in vivo. The relevance of this relates to the fact that IL-12 is involved in the pathogenesis of chronic inflammatory autoimmune disorders.…”

Section: Mechanismsmentioning

confidence: 99%

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Vitamin D and Age-Related Macular Degeneration

Yao

Chen

Jiang

et al. 2014

Handbook of Nutrition, Diet and the Eye

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Section: Mechanismsmentioning

confidence: 99%

“…The relevance of this relates to the fact that IL-12 is involved in the pathogenesis of chronic inflammatory autoimmune disorders. 34 Vitamin D 3 is one of the dominant regulators of the immune system and may protect against the process of aging. As mentioned above, drusen is the hallmark of AMD.…”

Section: Mechanismsmentioning

confidence: 99%

Vitamin D and Age-Related Macular Degeneration

Yao

Chen

Jiang

et al. 2014

Handbook of Nutrition, Diet and the Eye

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“…Visible light and inflammatory factors, such as bacterial lipopolysaccharide (LPS), have a strong influence not only on immune privilege within the eye but also on direct cell interactions and modulation of the expression of selected factors, including nitric oxide (NO) and cyclooxygenase-2 (COX-2) [1]. Bacteria are often a cause of serious ocular infections which lead to inflammation, making it difficult for the eye to maintain its normal corneal or conjunctival epithelial cell structure.…”

Section: Introductionmentioning

confidence: 99%

Reactivity of corneal and conjunctival epithelial cells to lipopolysaccharide (LPS) and/or irradiation with visible light in vitro

Paduch¹,

Matysik-Woźniak²,

Maciejewski³

et al. 2018

Ophthalmol J

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introduCtion. Visible light and inflammation caused by bacterial endotoxins strongly influence direct cell interactions and modulate the expression of selected factors, such as nitric oxide (NO) and cyclooxygenase-2 (COX-2). The aim of the study is to establish whether exposition of corneal or conjunctival epithelial cells to visible light and/ or LPS may change their viability, direct cellular interactions and expression of NO and COX-2. MateriaLs and Methods. In vitro cultured human corneal and conjunctival epithelial cells were used in the study. The following assays were performed: Neutral Red (NR) uptake, nitric oxide (NO) quantification by the Griess method, cytoskeletal F-actin organization by fluorescent staining, and COX-2 expression by immunofluorescence. resuLts. LPS reduced the viability of the cells, especially conjunctival epithelial cells. All cell stimulation variants tested (visible light and/or LPS treatment) led to decreased nitric oxide (NO) production both by corneal and conjunctival epithelial cells. No changes in cytoskeletal F-actin filaments were observed after the cells had been treated with light or the endotoxin. LPS slightly increased COX-2 expression, but light had no, or a slightly reducing, effect on the level of this enzyme. ConCLusions. Visible light and/or bacterial endotoxin (LPS) may, depending on the local microenvironmental conditions, cooperate or interfere with each other's activity in inducing ocular surface inflammation.

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“…Ultraviolet light ranges between 10 nm and 400 nm and sunlight consists of different bands of UV wavelength: UVA ranges between 400 and 315 nm; UVB ranges between 315 and 280 nm; UVC ranging between 280 and 100 nm (Hajrasouliha & Kaplan, 2012) Both vitamin D3 metabolite and vitamin D receptor mRNA have been measured in rabbit aqueous humour (Yin et al, 2011). Serum levels of 1,25(OH)2D3 were 4 times greater in free range rabbits compared to hutch reared rabbits.…”

Section: Vitamin D Within the Eye (Animal Work)mentioning

confidence: 99%

“…It is supposed that wavelengths between 295 and 297 nm are the most important for the formation of vitamin D (Hajrasouliha & Kaplan, 2012). …”

Section: Absorption and Transport Of Vitamin Dmentioning

confidence: 99%