Light and Moderate Alcohol Consumption Significantly Reduces the Prevalence of Fatty Liver in the Japanese Male Population

Gunji, Toshiaki; Matsuhashi, Nobuyuki; Sato, Hajime; Fujibayashi, Kazutoshi; Okumura, Mitsue; Sasabe, Noriko; Urabe, Akio

doi:10.1038/ajg.2009.361

Cited by 102 publications

(103 citation statements)

References 45 publications

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“…The National Institute on Alcohol Abuse and Alcoholism (NIAAA) defines heavy or at-risk drinking as more than 4 drinks on any day or more than 14 drinks per week in men or more than 3 drinks on any day or 7 drinks per week in women. 146 Several recent cross-sectional studies [147][148][149][150][151][152][153] suggest a beneficial effect of light alcohol consumption (on average less than one drink per day) on the presence (defined either biochemically or by imaging) and severity of NAFLD. There are no studies reporting the effect of ongoing alcohol consumption on disease severity or natural history of NAFLD or NASH.…”

Section: Bariatric Surgerymentioning

confidence: 99%

The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association

et al. 2012

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Section: Bariatric Surgerymentioning

confidence: 99%

The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association

et al. 2012

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“…Interestingly, in contrast, several studies have shown a beneficial effect of moderate alcohol intake. Moderate alcohol use was shown to be protective against insulin resistance in morbidly obese individuals [73] , was associated with decreased prevalence of fatty liver in asymptomatic individuals [99] , and with decreased prevalence of steatohepatitis in NAFLD patients [100] . The pathologist is not able to recognize the relative contributions of NAFLD or ALD to the liver injury in a biopsy with steatohepatitis.…”

Section: Histological Findings Of Nafld/ Nash In Concurrence With Othmentioning

confidence: 99%

Histopathology of Non-Alcoholic Fatty Liver Disease

Brunt

2009

Clinics in Liver Disease

114

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Histological analysis of liver biopsies remains a standard against which other methods of assessment for the presence and amount of hepatic injury due to nonalcoholic fatty liver disease (NAFLD) are measured. Histological evaluation remains the sole method of distinguishing steatosis from advanced forms of NAFLD, i.e. nonalcoholic steatohepatitis (NASH) and fibrosis. Included in the lesions of NAFLD are steatosis, lobular and portal inflammation, hepatocyte injury in the forms of ballooning and apoptosis, and fibrosis. However, patterns of these lesions are as distinguishing as the lesions themselves. Liver injury in adults and children due to NAFLD may have different histological patterns. In this review, the rationale for liver biopsy, as well as the histopathological lesions, the microscopically observable patterns of injury, and the differential diagnoses of NAFLD and NASH are discussed.

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“…044 and 0 . 008, respectively) (89) . In another study, also in Japanese population, the major risk factors for FL in Japanese men were factors related to adiposity, while consistent alcohol consumption (> 21 d/month) was inversely associated with the prevalence of FL (90) .…”

Section: Non-alcoholic Fatty Liver Diseasementioning

confidence: 99%

Potential health benefits of moderate alcohol consumption: current perspectives in research

et al. 2012

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The benefits of moderate amounts of alcohol for a better health and longer life expectancy compared with abstinence have been suggested by the findings of numerous studies. However, controversies have emerged regarding the influence of confounding factors and the systematic errors that might have been inadvertently disregarded in the early studies. This review includes a description of the findings of those research studies published in the last 5 years on the effects of moderate alcohol consumption on all-cause mortality, CVD and inflammation, the immune system, insulin sensitivity, non-alcoholic fatty liver disease (NAFLD) and cancer. Promising evidences exist from both animal studies and human clinical trials regarding intermediate end-points of CHD and insulin sensitivity, such as HDL, adiponectin or fibrinogen. However, controversies and inconsistent findings exist regarding many of these diseases and related functions and biomarkers. Further research and human randomised-controlled trials with adequate standardisation of the study conditions are necessary in order to draw a comparison between studies, establish the causal effect of moderate alcohol intake on disease protection and reach consensus on the circumstances that allow the recommendation of moderate alcohol habitual intakes as a strategy for health maintenance.

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Light and Moderate Alcohol Consumption Significantly Reduces the Prevalence of Fatty Liver in the Japanese Male Population

Abstract: The prevalence of FL was significantly and independently decreased by light and moderate alcohol consumption in men of an asymptomatic Japanese population.

Cited by 102 publications

References 45 publications

The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association

The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association

Histopathology of Non-Alcoholic Fatty Liver Disease

Potential health benefits of moderate alcohol consumption: current perspectives in research

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