Light and immunofluorescent study of the Arthus reaction in the rabbit lung

Zavala, Donald C.; Rhodes, Mitchell L.; Richerson, Hal B.; Oskvig, Roger M.

doi:10.1016/0091-6749(75)90063-9

Cited by 8 publications

(4 citation statements)

References 9 publications

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“…Recently it has been shown that most but not all HP patients have rather high concentrations of intermediate complexes in their serum sedimenting between the 7 S and 19 S peaks (2,3,10,13,15), and also that these may be gammaglobulin-antigammaglobulin complexes (2). Absence of intermediate complexes as in our patients does not rule out the possibility that circulating immune complexes may Acta Puediatr Scand 67 be present, for judged by a complement-consumption technique they seem to be present in many chronically infected C F patients (14), and there is some experimental evidence that immune complexes may provoke pulmonary damage (11,22).…”

Section: Discussionmentioning

confidence: 77%

Hypergammaglobulinemic Purpura in Cystic Fibrosis

et al. 1978

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Four patients are presented aged 14 to 20 years with cystic fibrosis and recurrent purpura of the legs. They have polyclonal increase of Ig but no intermediate complexes demonstrable by ultracentrifugation. The 4 patients differ from other patients with cystic fibrosis by a rapid deterioration of the clinical condition after the establishment of permanent pulmonary infection, and also by their proneness to Haemophilus influenzae infections. The clinical and laboratory findings are compatible with the diagnosis of Waldenström's hypergammaglobulinemic purpura. The heterogeneity of this syndrome is discussed.

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Section: Discussionmentioning

confidence: 77%

Hypergammaglobulinemic Purpura in Cystic Fibrosis

et al. 1978

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“…However, as noted above, it is unclear whether anti-alginate is protective. Such antibody could even be harmful if it forms part of immune complexes that exist in CF sera (2,16,18,20) or participates in an Arthus reaction (27). Animal protection studies may help answer this enigma.…”

Section: Discussionmentioning

confidence: 99%

Detection of antibodies to Pseudomonas aeruginosa alginate extracellular polysaccharide in animals and cystic fibrosis patients by enzyme-linked immunosorbent assay

Bryan¹,

Kureishi²,

Rabin³

1983

J Clin Microbiol

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An enzyme-linked immunosorbent assay was developed to detect antibodies to sodium alginate exopolysaccharide purified from three strains of Pseudomonas aeruginosa and commercial alginate from seaweed. Good attachment of alginate occurred with polystyrene microtiter plates at pH 7.0 with 0.04 M sodium phosphate buffer. With the enzyme-linked immunosorbent assay procedure, antibodies to alginate (not previously shown to be immunogenic) could be shown in humans and after immunization of mice and rabbits. Antibody to one of the alginates cross-reacted with two other P. aeruginosa alginates and commercial seaweed alginate. In animal immunization antibody titers were maximal after a single intravenous injection with an optimal dose of P. aeruginosa 3064 alginate. Healthy controls not known to have a previous P. aeruginosa infection had low, but detectable, antibody titers to 3064 and commercial alginate. Three cystic fibrosis patients not colonized with P. aeruginosa had similar antibody levels. Twenty-eight cystic fibrosis patients colonized with P. aeruginosa formed a clearly separate group with antibody titers higher than that of the control and noncolonized cystic fibrosis patients. Antibody titers to 3064 or commercial alginate did not increase during acute P. aeruginosa bronchopneumonitis in 16 cystic fibrosis patients or after repeated episodes in 4 patients.

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“…An Arthustype allergic reaction to Pseudomonas prod ucts could contribute to the pulmonary dam age in CF patients who have high levels of circulating antibody and large quantities of Pseudomonas antigens deposited in the lung. Arthus reactions have been implicated as the cause of pulmonary damage in rabbits after immunization and bronchial challenge with bovine immunoglobulin [154] and in an adult with chronic Pseudomonas respiratory infection [155], The same mechanism has been proposed but not proved in patients with CF.…”

Section: Allergymentioning

confidence: 99%

Host Defenses in Patients with Cystic Fibrosis: Modulation by <i>Pseudomonas aeruginos</i><i>a</i>

Speert¹

1985

Pathol Immunopathol Res

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Light and immunofluorescent study of the Arthus reaction in the rabbit lung

Cited by 8 publications

References 9 publications

Hypergammaglobulinemic Purpura in Cystic Fibrosis

Hypergammaglobulinemic Purpura in Cystic Fibrosis

Detection of antibodies to Pseudomonas aeruginosa alginate extracellular polysaccharide in animals and cystic fibrosis patients by enzyme-linked immunosorbent assay

Host Defenses in Patients with Cystic Fibrosis: Modulation by <i>Pseudomonas aeruginos</i><i>a</i>

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