Light and electron microscopic study of the effect of L-carnitine on the sperm morphology among sub fertile men

El-baset, Sohair A. Abd; El-Wahab, Samia M. Abd; Mansour, Aziza; Mohamed, E.A.

doi:10.1016/j.mefs.2010.04.005

Cited by 4 publications

(1 citation statement)

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“…Our findings on l ‐carnitine agree with those of Abd El‐Baset et al . () who studied the efficacy of l ‐carnitine on sperm morphology in subfertile males by light and electron microscopy. They found no statistically significant differences in the fertile control group.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of tamoxifen andl-carnitine on sperm ultrastructure and seminal oxidative stress in patients with idiopathic oligoasthenoteratozoospermia

et al. 2014

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Idiopathic oligoathenoteratozoospermia (iOAT) is a common finding in the evaluation of male infertility. Oxidative stress (OS) may underlie its pathology. Tamoxifen and l-carnitine are used to treat idiopathic male infertility. The aim of this work was to detect the efficacy of tamoxifen and l-carnitine on sperm parameters, sperm ultrastructure and seminal OS in iOAT patients. Sixty patients were recruited for this study and divided into three groups; the 1st was treated with tamoxifen, 2nd with l-carnitine and 3rd with both drugs. Semen analysis, malondialdehye (MDA) level and transmission electron microscopy were performed before and after three months treatment. The first group showed significant improvement in MDA levels, sperm concentration, sperm morphology, ultrastructural head, acrosomal and mitochondrial anomalies (P < 0.01). Other parameters were not significantly improved. In the 2nd group, significant improvements in MDA, sperm motility, sperm morphology, ultrastructural mitochondrial and tail anomalies were detected (P < 0.01). No significant improvement in the other parameters. Third group showed improvement in MDA, all semen parameters and all ultrastructural anomalies (P < 0.01). In conclusion, tamoxifen and l-carnitine are effective in improving seminal OS, semen parameters and sperm ultrastructure. Combination of both drugs is superior to monotherapy.

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Section: Discussionmentioning

confidence: 99%