Light and electron microscopic distribution of nerve growth factor receptor-like immunoreactivity in the skin of the rat lower lip

Ribeiro‐da‐Silva, Alfredo; Kenigsberg, R.L.; Cuello, A. Claudio

doi:10.1016/0306-4522(91)90322-f

Cited by 56 publications

(43 citation statements)

References 39 publications

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“…p75 IR has also been observed in the perineurium of axons in the human digital skin [Lopez et al, 1998], observations which correspond to the findings of p75 in perineurial locations of nerve fascicles in this study. It is known that the capsule of Ruffini corpuscles is Innervation in the Scapholunate Interosseous Ligament Cells Tissues Organs 2004;177:47-54 53 a continuation of the perineurium of the axon entering the corpuscle [Halata et al, 1999], and that the perineurial cells display NGF receptor reactions [Ribeiro-da-Silva et al, 1991], which correlates with the marked p75 reaction in the capsule of corpuscles found in this study.…”

Section: Discussionsupporting

confidence: 68%

General Innervation Pattern and Sensory Corpuscles in the Scapholunate Interosseous Ligament

Hagert

Ljung

Forsgren

2004

Cells Tissues Organs

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The scapholunate interosseous ligament (SLIL) is biomechanically important in maintaining wrist motion and grip strength in the hand, but its possible sensory role in the dynamic muscular stability of the wrist joint has not been examined. The aim of this study was to use immunohistochemical methods to analyze the general innervation and the possible existence of sensory corpuscles in the SLIL. The ligament was excised in its entirety from 9 patients. Antibodies against the low-affinity p75 neurotrophic receptor (p75) were used to reveal sensory corpuscles as well as general innervation. Furthermore, antibodies against the general nerve marker protein gene product 9.5 (PGP 9.5) and the glial marker S-100 were used to additionally depict innervation and corpuscular structures. Blood vessels occurred in areas interspersed throughout the homogenous collagenous structure. In these vascularized areas, the SLIL was found to be supplied with nerve fascicles and sensory corpuscles of both the Ruffini and lamellated type. p75 immunoreactivity (IR) was detected in association with the nerve fascicles and the corpuscles, particularly in their capsule. S-100 IR was found in the Schwann cells in the central regions of the corpuscle, and PGP 9.5 IR marked the axonal structures in the corpuscles. New information on neurotrophin receptor distribution in ligaments has been obtained here. The presence of nerve fascicles and particularly sensory corpuscles in the SLIL suggests that the ligament has a proprioceptive role in the stability of the wrist. The marked p75 IR further indicates that neurotrophins play a part in a proprioceptive system in the ligament, given the importance of neurotrophins in maintaining sensory function.

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Section: Discussionsupporting

confidence: 68%

General Innervation Pattern and Sensory Corpuscles in the Scapholunate Interosseous Ligament

Hagert

Ljung

Forsgren

2004

Cells Tissues Organs

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“…The trk proto-oncogene encodes a receptor for NGF (133,(149)(150)(151). In recent studies, this receptor has also been identified on human leukemic and cultured MCs at the mRNA and protein level, with its up-regulation by NGF itself (4,146).…”

Section: Ngfmentioning

confidence: 99%

Mast cells and their mediators in cutaneous wound healing – active participants or innocent bystanders?

Artuc

Hermes

Steckelings

et al. 1999

Experimental Dermatology

215

143

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Mast cells are traditionally viewed as effector cells of immediateNeukölln, Berlin, Germany type hypersensitivity reactions. There is, however, a growing body of evidence that the cells might play an important role in the maintenance of tissue homeostasis and repair. We here present our own data and those from the literature elucidating the possible role of mast cells during wound healing. Studies on the fate of mast cells in scars of varying ages suggest that these cells degranulate during wounding, with a marked decrease of chymase-positive cells, although the total number of cells does not decrease, based on SCF-receptor staining. Mast cells contain a plethora of preformed mediators like heparin, histamine, tryptase, chymase, VEGF and TNF-a which, on release during the initial stages of wound healing, affect bleeding and subsequent coagulation and acute inflammation. Various additional vasoactive and chemotactic, rapidly generated mediators (C3a, C5a, LTB 4 , LTC 4 , PAF) will contribute to these processes, whereas mast cell-derived proinflammatory and growth promoting peptide mediators (VEGF, FGF-2, PDGF, TGF-b, NGF, IL-4, IL-8) contribute to neoangiogenesis, fibrinogenesis or re-epithelization during the repair process. The increasing number of tryptase-positive mast cells in older Key words: mast cells -keratinocytesfibroblasts -wound healing -angiogenesis scars suggest that these cells continue to be exposed to specific chemotactic, growth-and differentiation-promoting factors throughout the proProf. Dr B. M. Henz, Exp. Dermatology, cess of tissue remodelling. All these data indicate that mast cells contribCharité-Virchow Clinic,

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“…Conversely, NT-3 over-expression in the epidermis leads to a significant increase in the number of dorsal root ganglion sensory neurons and an increase in Merkel cells per touch domes in the periphery, indicating that NT-3 is involved in the regulation of the final number of sensory neurons and Merkel cells (Albers et al, 1996). Immunohistochemical studies of p75NTR immunoreactivity in the skin of adult rats (Ribeiro-da-Silva et al, 1991;English et al, 1994) and the fetal human footpad (Narisawa et al, 1992) showed p75NTR immunoreactivity in Merkel cells in touch domes of the basal epidermis. p75NTR immunoreactivity is seen in the outer root sheath of the hair follicle at postnatal age day 3-6 of murine back skin (Botchkareva et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Neurotrophin‐3 signaling in mammalian Merkel cell development

Szeder

Grim

Kučera

et al. 2003

Developmental Dynamics

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Light and electron microscopic distribution of nerve growth factor receptor-like immunoreactivity in the skin of the rat lower lip

Cited by 56 publications

References 39 publications

General Innervation Pattern and Sensory Corpuscles in the Scapholunate Interosseous Ligament

General Innervation Pattern and Sensory Corpuscles in the Scapholunate Interosseous Ligament

Mast cells and their mediators in cutaneous wound healing – active participants or innocent bystanders?

Neurotrophin‐3 signaling in mammalian Merkel cell development

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