Light‐ and electron‐microscope studies on the granular cell myoblastoma of the tongue

Aparicio, S. R.; Lumsden, C. E.

doi:10.1002/path.1710970221

Cited by 114 publications

(37 citation statements)

References 21 publications

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“…EVERSOLE et al [23] believed that the varied light and electron microscopic features of granular cell tumors could not possibly have substantiated a single specific progenitor cell in three cases and tney proposed tne term gran mai SIICUL11 iunkin iu' this tumor. Other investigators also believe that this lesion does not arise from a single cell type [21,22,24,25]. In our present case the relationship to nerve fibers and the existence of axon were not observed, but the tumor cells resembled Schwann cells in view of electron microscopic observations where the nuclei and cell membrane, …”

Section: Discussionsupporting

confidence: 41%

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Granular cell tumor of the tongue A morphological report of a case with particular reference to histogenesis.

Kusama

Miyake

et al. 1982

The Journal of Nihon University School of Dentistry

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Section: Discussionsupporting

confidence: 41%

“…Most authors now believe that the tumor is not derived from a single cell type [21][22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Granular cell tumor of the tongue A morphological report of a case with particular reference to histogenesis.

Kusama

Miyake

et al. 1982

The Journal of Nihon University School of Dentistry

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“…This theory has been challenged, however, by the presence of tumours in organs that lack striated muscle, 30 the absence of glycogen in tumour cells, and the absence of any similarity between tumour cells and striated muscle under electron microscopy (EM). 31 Researchers have subsequently proposed other cells of origin, including fibroblasts 32 and primitive mesenchymal cells, 10 as well as an origin resulting from metabolic derangement involving histiocytes. 33 The idea of GCT derivation from Schwann cells has gained popularity recently, mainly on the basis of evidence that the cytoplasmic granules in Schwann cells are indistinguishable from those found in GCT cells.…”

Section: Discussionmentioning

confidence: 99%

Orbital granular cell tumours: clinical and pathologic characteristics of six cases and literature review

Qian

et al. 2016

Eye

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Objective To retrospectively assess the clinicopathological characteristics of orbital granular cell tumours (GCTs). Methods A non-comparative review of the clinical characteristics, imaging, histopathological features, management, and prognosis of five cases of benign GCT and one case of malignant GCT (MGCT) was conducted, along with a review of the English language literature. Results Among the six cases, four tumours were adherent to the extraocular muscle (EOM), and three tumours to the optic nerve (ON). Morphologic examinations revealed polygonal cells containing periodic-acid-Schiff-positive eosinophilic granules. All tumours (100%) were positive for VIM and NSE, five (83.3%) tumours were positive for S-100, and three (50%) tumours were positive for CD68. The follow-up examination of the MGCT witnessed recurrence and brain metastasis despite several thorough resections, but the patient remained alive; the follow-up examination of the four benign GCTs that had received incomplete excision revealed recurrence in one patient and dramatic shrinkage of the residual tumour in another; there was no recurrence in the other two patients. Conclusions GCT should be considered in the differential diagnosis of orbital tumours, which may affect EOMs and ON. The natural course of GCT can include tumour progression, stability, or spontaneous regression. To avoid recurrence, complete resection is recommended for orbital GCT. To the best of our knowledge, primary orbital MGCT is reported for the first time.

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“…Histopathologically, it consists of S-100-protein-positive polygonal cells with abundant cytoplasm containing brightly acidophilic and PAS-positive and diastase-resistant granules [18]. …”

Section: Discussionmentioning

confidence: 99%

Eyelid Swelling: Think of Metastasis of Histiocytoid Breast Carcinoma

2002

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Metastatic breast carcinoma may assume many clinicopathological patterns. We here describe a case of histiocytoid breast carcinoma metastasis in the eyelids of a 73-year-old woman. Clinically, the patient presented painless swelling and nodular infiltration of the lateral and medial portions of the eyelids recalling a xanthomatous process or cystic lesions. Physical examination revealed similar lesions on the neck and right thigh. Medical history had revealed breast carcinoma 5 years previously. A biopsy specimen taken from a nodule on the eyelids revealed a relatively symmetric dermal tumor composed mainly of large, uniform, round-to-oval cells embedded in a fibrous stroma with moderate mucin deposits. The cells had abundant, coarsely granular eosinophilic cytoplasm and scant or absent nuclear atypia. No lobular arrangement of the cells or overt ductal formation were seen. Only occasional intracytoplasmic lumina were observed. Most cells demonstrated a positive immunoreaction for carcinoembryonic antigen. It is important to recognize histiocytoid breast carcinoma metastasis in the eyelids, because it may easily be overlooked clinically and histopathologically. This tumor should not be confused histopathologically with other benign and malignant skin tumors containing similar granular cells, but which have a different significance or a different prognosis. The immunohistochemical study, in conjunction with the medical history of the patient, facilitated the diagnosis.

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Light‐ and electron‐microscope studies on the granular cell myoblastoma of the tongue

Cited by 114 publications

References 21 publications

Granular cell tumor of the tongue A morphological report of a case with particular reference to histogenesis.

Granular cell tumor of the tongue A morphological report of a case with particular reference to histogenesis.

Orbital granular cell tumours: clinical and pathologic characteristics of six cases and literature review

Eyelid Swelling: Think of Metastasis of Histiocytoid Breast Carcinoma

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