Light Alcohol Drinking and Risk of Cancer: A Meta-Analysis of Cohort Studies

Choi, Yoon-Jung; Myung, Seung‐Kwon; Lee, Ji-Ho

doi:10.4143/crt.2017.094

Cited by 120 publications

(105 citation statements)

References 46 publications

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“…The literature supports the fact that alcohol consumption, for the vast majority of conditions has a linear relationship between the volume of alcohol consumed and the risk of morbidity and mortality [15][16][17]. Alcohol abuse and dependence are clearly associated with an increased health service use and it has been shown that alcohol reduction and abstention in this specific population reduce health service use [8,18].…”

Section: Introductionmentioning

confidence: 68%

Risky Alcohol Use: The Impact on Health Service Use

et al. 2018

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Objective: To examine health services use on the basis of alcohol consumption. Material and Methods: A cross-sectional study was carried out on patients visiting the Primary Health Care (PHC) settings in Catalonia during 2011 and 2012; these patients had a history of alcohol consumption. Information about outpatient visits in the PHC setting, hospitalizations, specialists’ visits and emergency room visits for the year 2013 was obtained from 2 databases (the Information System for the Development of Research in PHC and the Catalan Health Surveillance System). Risky drinkers were defined as those who consumed more than 280 g per week for men or more than 170 g per week for women, or any amount of alcohol while being involved in a high risk work activity, or taking medication that significantly interferes with alcohol or when being pregnant. Binge drinkers (> 60 g in men or > 50 g in women in a short amount of time more than once a month) were also considered risky drinkers. Results: A total of 606,948 patients reported consuming alcohol (of which 10.5% were risky drinkers). Risky drinkers were more likely to be admitted to hospitals or emergency departments (range of ORs 1.08–1.18) compared to light drinkers. Male risky drinkers used fewer PHC services than male light drinkers (OR 0.89, 95% CI 0.87–0.92). In general, risky alcohol users used services more and had longer hospital stays. When stratifying by socioeconomic level of the residential area, we found that risky drinking failed significance, while current or past cigarette smoking was associated with higher healthcare use. Conclusions: Risky drinkers use more expensive services, such as hospitals and emergency rooms, but not PHC services, which may suggest that prevention strategies and alcohol interventions should also be implemented in those settings.

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Section: Introductionmentioning

confidence: 68%

Risky Alcohol Use: The Impact on Health Service Use

et al. 2018

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“…A second meta-analysis based on 10 studies, demonstrated a decrease in risk of lung cancer for light alcohol drinking (RR 0.91 95%CI: 0.90-0.94 I2=0) (29).…”

Section: Alcohol Consumption and The Risk Of Lung Cancermentioning

confidence: 99%

Light alcohol drinking and the risk of developing cancer, a systematic review.

Ciardiello

Caprio

Picascia

et al. 2019

Preprint

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Background: There is strong evidence that heavy alcohol consumption (>50g per day) is a risk factor for several disease, including cancer. However, the oncogenic role of light alcohol drinking (<12,5g per day) is still controversial. The purpose of this review is to assess whether the intake of a single daily dose of alcohol could determine an increased risk of malignancy onset. Methods: A systemic PubMed research of meta-analysis studies, using the keywords “light alcohol drinking”, “light alcohol consumption” and “cancer”, was done. We established a period of 15 years, in order to select the most recent evidences; exclusively meta-analysis that specified levels of alcohol intake were included in the review. Studies focused on biochemical, molecular and genetic aspects, as well as duplicate articles were excluded. Results: We included in this review 29 large meta-analysis; light alcohol drinking was not associated with an increased risk of occurrence of most cancers, with the exception of breast, prostate cancer and, with less evidence, melanoma. Furthermore, a protective role of alcohol assumption on the development of bladder, kidney ovarian cancer and Non Hodgkin Lymphoma (NHL), has been described.Conclusions: We found that light alcohol drinking do not determine a higher risk for the insurgence of several malignancies, except for a light increase in the incidence of melanoma, breast cancer in women and prostate cancer in men.

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“…17,22) In terms of carcinogenesis, acetaldehyde, a primary product of alcohol metabolism, has toxic effects, accelerating the production of reactive oxygen and nitrogen species to impact folate and methionine metabolism and DNA repair mechanisms, causing the development of cancerous cells. 16,23) The limitations of this study are as follows. First, it is probable that the subjects' subjective opinions were included because their lifestyle habits were collected through a self-administered questionnaire.…”

Section: Association Between Drinking Behavior Changes and Cardiovascmentioning

confidence: 99%

Risk Factors of Cardiovascular Disease according to Alcohol Behavioral Change after Cancer Diagnosis

et al. 2020

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Background: Problem drinking increases the incidence of all-cause mortality and specific cancers, and persistent drinking is associated with cardiovascular disease in certain cancer survivors. This study analyzed the cardiovascular risk factors before and after diagnosis in Korean cancer survivors. Methods: Data for the period between 2002 and 2013 were collected from the National Health Insurance Service Health-Examinee Cohort Database. Among the 27,835 patients included, those with moderate alcohol consumption before and after cancer diagnosis were excluded. Problem drinking was defined as males under 65 years consuming over 14 glasses a week, and males over 65 years or females consuming over seven glasses a week. A t-test, chi-square test, and linear regression analysis were performed for differences in cardiovascular risk factors and differences according to cancer types. Results: There was a difference in the body mass index, systolic and diastolic blood pressure, and total cholesterol among patients who became moderate drinkers after diagnosis, but fasting blood glucose did not show any significant changes. Risk factors for cardiovascular disease were analyzed in patients with liver, stomach, rectal, and breast cancer with improved drinking behavior, and there were significant differences in body mass index, systolic and diastolic blood pressure, fasting blood glucose, and total cholesterol in stomach cancer patients. Conclusion: Moderate drinking can lower cardiovascular risk in cancer survivors, and among the many drinkingrelated cancers, stomach cancer patients demonstrated significantly reduced cardiovascular risk factors.

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Light Alcohol Drinking and Risk of Cancer: A Meta-Analysis of Cohort Studies

Cited by 120 publications

References 46 publications

Risky Alcohol Use: The Impact on Health Service Use

Risky Alcohol Use: The Impact on Health Service Use

Light alcohol drinking and the risk of developing cancer, a systematic review.

Risk Factors of Cardiovascular Disease according to Alcohol Behavioral Change after Cancer Diagnosis

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