Light adaptation in cone vision involves switching between receptor and post-receptor sites

Dunn, Felice A.; Lankheet, M.J.M.; Rieke, Fred

doi:10.1038/nature06150

Cited by 176 publications

(210 citation statements)

References 25 publications

Supporting

Mentioning

172

Contrasting

Unclassified

Order By: Relevance

“…We find that mechanisms behind SFA for TN1 are distributed over several levels of processing (Fig. 8), thus matching the expectations for summation over many inputs (1) as also observed in the visual pathway of vertebrates (Solomon et al, 2004;Dunn et al, 2007). …”

Section: Functional Role Of the Distribution Of Adaptation Mechanismssupporting

confidence: 51%

The Origin of Adaptation in the Auditory Pathway of Locusts Is Specific to Cell Type and Function

Hildebrandt¹,

Benda²,

Hennig³

2009

J. Neurosci.

View full text Add to dashboard Cite

We investigated the origin of spike frequency adaptation within a layered sensory network: the auditory pathway of locusts. Spike frequency adaptation as observed in an individual neuron may arise because of intrinsic or presynaptic adaptation mechanisms. To separate the contribution of different mechanisms, we recorded from the same cell during acoustic and intracellular current stimulation. We studied three identified neuron types that are representative for each network layer and participate in processing auditory patterns and localizing sound sources. By comparing current and acoustic stimulation, three distinct patterns of the distribution of adaptation mechanisms within the sensory network emerged: (1) balanced influence of both intrinsic and presynaptic adaptation mechanisms in an interneuron that summates over several receptor afferents (TN1), (2) predominantly inhibiting input as the source for spike frequency adaptation in a cell that transmits both pattern representation and directional information (BSN1), (3) primarily intrinsic, spiketriggered adaptation currents within an interneuron coding exclusively for direction (AN2). The time courses of spike frequency adaptation differed significantly between the cells types. Using the adaptation time constants, we were able to predict signal transmission properties for the different cells. We conclude that the adaptation mechanisms differ greatly among interneurons within this sensory pathway and are a function of their role in information processing.

show abstract

Section: Functional Role Of the Distribution Of Adaptation Mechanismssupporting

confidence: 51%

The Origin of Adaptation in the Auditory Pathway of Locusts Is Specific to Cell Type and Function

Hildebrandt¹,

Benda²,

Hennig³

2009

J. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Thus a light-induced feedback stemming from the basic glutamatergic routes of the retina seems unlikely. Specifically, the horizontal cell light responses of the macaque retina are abolished by a lower dose (5 M) of NBQX (Dunn et al 2007). Also, in the rabbit retina, the light responses of A-type horizontal cells are completely eliminated in a HEPES-buffered superfusate lacking bicarbonate (Hanitzsch and Küppers 2001), which treatment also failed to prevent light-induced cone response growth in our control experiments (data not shown).…”

Section: Discussionmentioning

confidence: 80%

“…Figure 4A compares the cone responses of one retina under darkness and in the steady state following exposure to 4,600 h 543.5nm m Ϫ2 s Ϫ1 (320 P*s Ϫ1 ). This background is expected to suppress a large portion of the light-sensitive current in mouse rods but not to affect the cone-circulating current (Nikonov et al 2006) or to desensitize mammalian cones substantially (Dunn et al 2007). The cone responses were further enhanced by a 10-fold increase of the background intensity to 3,200 P*s Ϫ1 (Fig.…”

mentioning

confidence: 99%

Mesopic background lights enhance dark-adapted cone ERG flash responses in the intact mouse retina: a possible role for gap junctional decoupling

Heikkinen

Vinberg

Nymark

et al. 2011

Journal of Neurophysiology

View full text Add to dashboard Cite

Heikkinen H, Vinberg F, Nymark S, Koskelainen A. Mesopic background lights enhance dark-adapted cone ERG flash responses in the intact mouse retina: a possible role for gap junctional decoupling. J Neurophysiol 105: 2309 -2318, 2011. First published March 9, 2011 doi:10.1152/jn.00536.2010.-The cone-driven flash responses of mouse electroretinogram (ERG) increase as much as twofold over the course of several minutes during adaptation to a rod-compressing background light. The origins of this phenomenon were investigated in the present work by recording preflash-isolated (M-)cone flash responses ex vivo in darkness and during application of various steady background lights. In this protocol, the cone stimulating flash was preceded by a preflash that maintains rods under saturation (hyperpolarized) to allow selective stimulation of the cones at varying background light levels. The light-induced growth was found to represent true enhancement of cone flash responses with respect to their darkadapted state. It developed within minutes, and its overall magnitude was a graded function of the background light intensity. The threshold intensity of cone response growth was observed with lights in the low mesopic luminance region, at which rod responses are partly compressed. Maximal effect was reached at intensities sufficient to suppress ϳ90% of the rod responses. Light-induced enhancement of the cone photoresponses was not sensitive to antagonists and agonists of glutamatergic transmission. However, applying gap junction blockers to the dark-adapted retina produced qualitatively similar changes in the cone flash responses as did background light and prevented further growth during subsequent light-adaptation. These results are consistent with the idea that cone ERG photoresponses are suppressed in the dark-adapted mouse retina by gap junctional coupling between rods and cones. This coupling would then be gradually and reversibly removed by mesopic background lights, allowing larger functional range for the cone light responses.photoreceptor; retina; rod-cone coupling; light adaptation; electroretinogram THE VERTEBRATE RETINA IS A specialized neural tissue that collects, processes, and transmits information about the spatial, spectral, and temporal features of the light reaching the eye. Through a range of powerful adaptational mechanisms, the retina manages to produce visual information over 10 9 -fold range of light-intensities. The grounds for this impressive performance are laid already at the level of photoreceptor cells, which adjust their signal transduction cascade in response to changes in the average illumination level. Visual processing is further optimized by the existence of two main photoreceptor classes: the highly sensitive rods convey visual messages in darkness, while the higher temporal performance and faster adaptation of daylight vision are based on the function of the cones. However, between these two extremes there is a significant range of light conditions at which these two photoreceptor classes ...

show abstract

“…In addition to gain controls in photoreceptors (Burns and Baylor 2001;Fain et al 2001) and postreceptor circuits (Dunn et al 2006(Dunn et al , 2007, the retina is thought to maintain responsiveness by switching between cell types and pathways optimized to function at different light levels. At the input stage, rods and cones mediate phototransduction in dim and bright environments, respectively.…”

mentioning

confidence: 99%

Ambient illumination switches contrast preference of specific retinal processing streams

Pearson

Kerschensteiner

2015

Journal of Neurophysiology

View full text Add to dashboard Cite

show abstract

Light adaptation in cone vision involves switching between receptor and post-receptor sites

Cited by 176 publications

References 25 publications

The Origin of Adaptation in the Auditory Pathway of Locusts Is Specific to Cell Type and Function

The Origin of Adaptation in the Auditory Pathway of Locusts Is Specific to Cell Type and Function

Mesopic background lights enhance dark-adapted cone ERG flash responses in the intact mouse retina: a possible role for gap junctional decoupling

Ambient illumination switches contrast preference of specific retinal processing streams

Contact Info

Product

Resources

About