Light-Activated Zirconium(IV) Phthalocyanine Derivatives Linked to Graphite Oxide Flakes and Discussion on Their Antibacterial Activity

Łukowiak, Anna; Gerasymchuk, Yuriy; Wedzynska, Anna; Tahershamsi, Leili; Tomala, Robert; Stręk, W.; Piątek, Dominika; Korona-Głowniak, Izabela; Speruda, Mateusz; Kędziora, Anna; Bugla-Płoskońska, Gabriela

doi:10.3390/app9204447

Cited by 7 publications

(7 citation statements)

References 23 publications

(29 reference statements)

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“…In this study, synthesis of composites was already performed in a way to ensure relatively high concentration of ZrPc and it would be difficult to obtain higher phthalocyanine content. But it must be noted that structure of complexes with different functionalities absolutely affects the attachment process that further influence on the 1 O 2 generation as reported in our previous studies of other ligands bonded to ZrPc [38,47].…”

Section: Discussionmentioning

confidence: 73%

Synthesis, Spectroscopic Characterization and Photoactivity of Zr(IV) Phthalocyanines Functionalized with Aminobenzoic Acids and Their GO-Based Composites

Tahershamsi

Gerasymchuk

Wedzynska

et al. 2019

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Two complexes of bis(aminobenzoato)zirconium(IV) phthalocyanine and their graphite oxide-based composites were synthesized and characterized in respect of their photochemical properties. Structures of phthalocyanines were confirmed by Mass and infrared spectroscopies. The absorption and photoluminescence spectra were investigated to show various behavior of the complexes in different media (dimethyl sulfoxide and saline). Optical technique (monitoring variation of absorption spectra of diphenylisobenzofuran used as an indicator) was used to prove the generation of reactive oxygen species (ROS) by under light irradiation in the range of the first biological window. The photoactivity of the materials was compared and discussed in terms of their potential ability to be used in biomedical applications, for example, as photosensitizers in photodynamic therapy.

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Section: Discussionmentioning

confidence: 73%

Synthesis, Spectroscopic Characterization and Photoactivity of Zr(IV) Phthalocyanines Functionalized with Aminobenzoic Acids and Their GO-Based Composites

Tahershamsi

Gerasymchuk

Wedzynska

et al. 2019

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“…The following samples described in detail previously [ 9 , 29 , 44 , 45 ] were tested in this study: pure graphite oxide (GO), GO-PcZr(Lys) 2 -Ag (0.5 g/10 mL) (IV), GO-Ag (0.5 g/10 mL) (V), and GO-PcZr(Lys) 2 (VI). A brief scheme of composites preparation is shown in Figure 9 .…”

Section: Methodsmentioning

confidence: 99%

The Impact of Graphite Oxide Nanocomposites on the Antibacterial Activity of Serum

Morka

Wernecki

Kędziora

et al. 2021

IJMS

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Nanoparticles can interact with the complement system and modulate the inflammatory response. The effect of these interactions on the complement activity strongly depends on physicochemical properties of nanoparticles. The interactions of silver nanoparticles with serum proteins (particularly with the complement system components) have the potential to significantly affect the antibacterial activity of serum, with serious implications for human health. The aim of the study was to assess the influence of graphite oxide (GO) nanocomposites (GO, GO-PcZr(Lys)2-Ag, GO-Ag, GO-PcZr(Lys)2) on the antibacterial activity of normal human serum (NHS), serum activity against bacteria isolated from alveoli treated with nanocomposites, and nanocomposite sensitivity of bacteria exposed to serum in vitro (using normal human serum). Additionally, the in vivo cytotoxic effect of the GO compounds was determined with application of a Galleria mellonella larvae model. GO-PcZr(Lys)2, without IR irradiation enhance the antimicrobial efficacy of the human serum. IR irradiation enhances bactericidal activity of serum in the case of the GO-PcZr(Lys)2-Ag sample. Bacteria exposed to nanocomposites become more sensitive to the action of serum. Bacteria exposed to serum become more sensitive to the GO-Ag sample. None of the tested GO nanocomposites displayed a cytotoxicity towards larvae.

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“…Due to transesterification, ethyl groups were replaced with pentyl ones during the cyclotetramerization of compound 1 in n-pentanol. 51 The content was cooled to room temperature, treated with a mixture of methanol:water (2:1) and stirred for 1 h. The crude product was centrifuged and dried. The newly synthesized compound was purified by performing a column chromatographic technique.…”

Section: ■ Introductionmentioning

confidence: 99%

Biological Performance of Hexadeca-Substituted Metal Phthalocyanine/Reduced Graphene Oxide Nanobioagents

Farajzadeh Öztürk,

Özdemir,

Yalçın

et al. 2024

ACS Appl. Bio Mater.

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This study presents a tetra-substituted phthalonitrile derivative, namely, diethyl 2-(3,4dicyano-2,5-bis(hexyloxy)-6-(4-(trifluoromethoxy)phenoxy)phenyl)malonate (a), cyclotetramerizing in the presence of some metal salts. The resultant hexadeca-substituted metal phthalocyanines [M= Co, Zn, InCl)] (b−d) were used for the modification of reduced graphene oxide for the first time. The effect of the phthalonitrile/metal phthalocyanines on biological features of reduced graphene oxide (rGO) was extensively examined by the investigation of antioxidant, antimicrobial, DNA cleavage, cell viability, and antibiofilm activities of nanobioagents (1−4). The results were compared with those of unmodified rGO (nanobioagent 5), as well. Modification of reduced graphene oxide with the synthesized compounds improved its antioxidant activity. The antioxidant activities of all the tested nanobioagents also enhanced as the concentration increased. The antibacterial activities of all the nanobioagents improved by applying the photodynamic therapeutic (PDT) method. All the phthalonitrile/phthalocyanine-based nanobioagents (especially phthalocyanine-based nanocomposites) exhibited DNA cleavage activities, and complete DNA fragmentation was observed for nanobioagents (1−4) at 200 mg/L. They can be used as potent antimicrobial and antimicrobial photodynamic therapy agents as well as Escherichia coli microbial cell inhibitors. As a result, the prepared nanocomposites can be considered promising candidates for biomedicine.

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Light-Activated Zirconium(IV) Phthalocyanine Derivatives Linked to Graphite Oxide Flakes and Discussion on Their Antibacterial Activity

Cited by 7 publications

References 23 publications

Synthesis, Spectroscopic Characterization and Photoactivity of Zr(IV) Phthalocyanines Functionalized with Aminobenzoic Acids and Their GO-Based Composites

Synthesis, Spectroscopic Characterization and Photoactivity of Zr(IV) Phthalocyanines Functionalized with Aminobenzoic Acids and Their GO-Based Composites

The Impact of Graphite Oxide Nanocomposites on the Antibacterial Activity of Serum

Biological Performance of Hexadeca-Substituted Metal Phthalocyanine/Reduced Graphene Oxide Nanobioagents

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