Light-Activatable Theranostic Agents for Image-Monitored Controlled Drug Delivery

Drug carriers with intelligent functions are powerful therapeutic and diagnostic platforms in curing various diseases such as malignant neoplasms. These functions include the remote noninvasive activation of drug using physical impacts, e.g. light exposure. Combination of different therapeutic modalities (chemotherapy, photodynamic therapy, and so forth) with light-responsive carriers enables promising synergetic effect in tumour treatment. The main goal of this review article is to provide the state of the art on light-sensitive delivery systems with the identification of future directions and their implementation in tumour treatment. In particular, this article reviews the general information on the physical and chemical fundamental mechanisms of interaction between light and carrier systems (e.g. plasmonic and dielectric nanoparticles), the design of optically responsive drug carriers (plain and composite), and the mechanisms of light-driven controlled release of bioactive compounds in biological environment. The special focus is dedicated to the most recent advances in optically responsive bioinspired drug vehicles.

show abstract

“…photoacoustic imaging technique. This results in theranostic platform for an effective therapy and diagnosis [208,209].…”

Section: Polymersmentioning

confidence: 99%

Optically responsive delivery platforms: from the design considerations to biomedical applications

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Laser interaction with absorbing nanoparticles in liquids is in the core of several current and emerging applications, including the selective killing of cancer cells, − biological imaging, , drug delivery, , and laser processing of colloidal solutions of nanoparticles. − The latter includes laser fragmentation in liquid (LFL), − where larger nanoparticles are fragmented to produce a population of smaller nanoparticles with a narrow size distribution, and laser melting in liquid, − where melting and partial vaporization of nanoparticles is used to change the size, , shape, , and composition of the colloidal nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Atomistic View of Laser Fragmentation of Gold Nanoparticles in a Liquid Environment

Huang

Zhigilei

2021

J. Phys. Chem. C

View full text Add to dashboard Cite

Short-pulse laser irradiation of a colloidal solution of nanoparticles is an effective method for fragmenting the nanoparticles and producing a population of smaller nanoparticles and atomic clusters with properties desired in various fields of applications, including biology, medicine, and catalysis. To investigate the mechanisms involved in the fragmentation, we develop a computational model capable of realistic treatment of a variety of interrelated processes occurring on different time and length scales, from the electronic excitation by the laser pulse, to the electron–phonon energy transfer and an explosive phase decomposition of the superheated nanoparticle, and to the generation and collapse of a nanobubble in a liquid environment. The application of the model to simulation of laser fragmentation of a Au nanoparticle in water has revealed two distinct channels of the formation of the fragmentation products. The first channel involves the direct injection of compact nanodroplets propelled by the phase explosion of the irradiated nanoparticle deep into the water environment. The second channel of the nanoparticle formation involves a more gradual growth through agglomeration of numerous atomic clusters embedded into a narrow region of water surrounding the laser-induced nanobubble. This channel produces irregularly shaped nanoparticles and leads to a rapid decline of the population of atomic clusters on the timescale of nanoseconds. All the clusters and nanoparticles experience an ultrafast quenching by the water environment and feature a high density of twin boundaries and other crystal defects, which may enhance the density of active sites for the catalytic applications of the nanoparticles. The computational predictions of the prompt generation of a high concentration of the fragmentation products in a relatively narrow shell-like region on the outer side of the nanobubble, as well as the rapid solidification of atomic clusters and nanoparticles at the early stage of the nanobubble formation, have important practical implications for the design of new methods aimed at achieving an improved control over the size, shape, and defect structures of nanoparticles produced by laser fragmentation in liquids.

show abstract

“…The perfluorocarbon (PFC) nanodroplets were obtained via a double emulsion procedure, as described in our previous studies. − Briefly, to prepare the first emulsion, DOX solution (0.3 mL, 10 mg/mL) was dispersed in 1.55 mL of liquid perfluoropentane (C 5 F 12 ) with 0.15 mL of Krytox as the surfactant by a tip sonicator at pulse mode (10 s on and 20 s off at 20% amp.) for 1 min in an ice bath.…”

Section: Methodsmentioning

confidence: 99%

“…This structure reversibility may be responsible for repetitive drug release with multiple laser exposures over a prolonged time period. To test our hypothesis, we measured the number density of the liposomes after laser irradiation using a single-particle collision electrochemical method and compared them to phase-transition (liquid-to-gas) nanodroplets, which undergo irreversible structural change after laser heating by laser. − …”

Section: Introductionmentioning

confidence: 99%

Effect of Laser Irradiation on Reversibility and Drug Release of Light-Activatable Drug-Encapsulated Liposomes

et al. 2020

Self Cite

View full text Add to dashboard Cite

Although several studies have demonstrated repetitive drug release using light-activatable liposomes, inconsistent drug release at each activation limits widespread usage. Here, we report reversible plasmonic material-coated encapsulated liposomes for proportional controlled delivery of methotrexate (MTX), which is a common drug for cancer and autoimmune diseases, using repetitive laser irradiation. Our results suggest a proportional increase in total drug release after repetitive laser irradiation. We hypothesize that the drug is released via "melted" lipid bilayers when the plasmonic materials on the liposome surface are heated by laser irradiation followed by reversible formation of the liposome. To evaluate our hypothesis, the number density of liposomes after laser irradiation was measured using single-particle (liposome) collision experiments at an ultramicroelectrode. Collisional frequency data suggest that the number density of liposomes remains unaltered even after 60 s of laser irradiation at 1.1 and 1.8 W, indicating that the liposome structure is reversible. The results were further compared with gold nanorod-coated nanodroplets where drug is released via irreversible phase transition. In contrast to what was observed with the liposome particles, the number density of the nanodroplets decreased with increasing laser irradiation duration. The structure reversibility of our liposome particles may be responsible for repetitive drug release with laser heating. We also studied the temperature rise in the lipid bilayer by incorporating polymerized 10,12pentacosadiynoic acid (PCDA) in the lipid composition. The red shift in the UV−vis spectrum due to the structural change in PCDA lipids after laser irradiation indicates a rise in temperature above 75 °C, which is also above the chain-melting temperature of the main lipid used in the liposomes. All these results indicate that drug is released from the light-activatable liposomes due to reversible nanostructural alteration in the lipid bilayer by plasmonic resonance heating. The liposomes have potential to be a drug carrier for dose-controlled repetitive drug delivery.

show abstract

Light-Activatable Theranostic Agents for Image-Monitored Controlled Drug Delivery

Cited by 18 publications

References 33 publications

Optically responsive delivery platforms: from the design considerations to biomedical applications

Optically responsive delivery platforms: from the design considerations to biomedical applications

Atomistic View of Laser Fragmentation of Gold Nanoparticles in a Liquid Environment

Effect of Laser Irradiation on Reversibility and Drug Release of Light-Activatable Drug-Encapsulated Liposomes

Contact Info

Product

Resources

About