Ligational behaviour of lomefloxacin drug towards Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Th(IV) and UO2(VI) ions: Synthesis, structural characterization and biological activity studies

El‐Halim, Hanan F. Abd; Mohamed, Gehad G.; El-Dessouky, M. M.; Mahmoud, Walaa H.

doi:10.1016/j.saa.2011.05.089

Cited by 75 publications

(20 citation statements)

References 42 publications

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“…The high spin octahedral cobalt(II) complex exhibited three electronic transitions in electronic spectrum from ground state 4 T 1g (F) to the excited states 4 T 2g (F), 4 A 2g (F) and 4 T 2g (P), due to three absorption bands at 700, 515 and 446 nm respectively [18,24,26]. The electronic spectrum of the Cu(II) complex showed two bands at 640 and 530 nm, are assigned to 2 B 1 → 2 B 2 and 2 B 1 → 2 E transitions respectively, which suggested octahedral geometry [7,23,27].…”

Section: Magnetic Susceptibility and Electronic Spectramentioning

confidence: 96%

“…The appearance of broad band at around 3357-3438 cm -1 in the spectra of Cr(II), Mn(II), Fe(II) and Cu(II) complexes, has been assigned to associated water molecules [19,21]. Besides, the water containing complexes did not show any weak band at nearly 860 cm -1 indicating the absence of coordinated water molecule in the complexes [22,23].…”

Section: Infrared Spectramentioning

confidence: 99%

“…The magnetic susceptibilities of the test complexes are included in Table 3. The magnetic moments of the Cr(III), Mn(II), Fe(II), Co(II) and Cu(II) complexes [23,24,25,26,27] were corresponded to three, five, four, three and one unpaired electron respectively. The electronic spectra data of the ligand and its Cr(III), Mn(II), Fe(II), Co(II) and Cu(II) complexes were recorded in DMSO solution as shown in the Table 3.…”

Section: Magnetic Susceptibility and Electronic Spectramentioning

confidence: 99%

“…The electronic spectrum of Cr(III) complex showed three absorption bands at 605, 465 and 410 nm. The three spin-allowed transitions for chromium(III) in an octahedral field are: 4 A 2g → 4 T 2g (F), 4 A 2g → 4 T 1g (F) and 4 A 2g → 4 T 1g (P) [23,28]. The Mn(II) complex exhibited bands at 663, 478, 402 nm assigned to 6 A 1g → 4 T 1g , 6 A 1g → 4 T 2g and 6 A 1g → 4 A 1g , 4 E g transitions, respectively, suggested spin-free manganese(II) complex with octahedral geometry [29,30].…”

Section: Magnetic Susceptibility and Electronic Spectramentioning

confidence: 99%

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Physico-Chemical Characterization and Biological Screening of Cyanex 302 complexes

et al. 2012

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Several new complexes of Cr(III), Mn(II), Fe(II), Co(II) and Cu(II) containing Cyanex 302 [bis(2,4,4-trimethylpentyl) monothiophosphinic acid] were synthesized and characterized by elemental analysis, molar conductance, molecular mass determination, magnetic, UV-Visible and IR studies. The prepared metal complexes has the compositions: 2. [CrL3].H2O, 3. K[MnL3].H2O, 4. [FeL2].H2O, 5. K[CoL3] and 6. K[CuL3].H2O (Where, L means anion of bis(2,4,4-trimethylpentyl) monothiophosphinic acid). The complexes 2, 3, 5 and 6 are assumed to have octahedral geometries, but the complex 4 is tetrahedral based on experimental data. From magnetic measurements all the complexes are found to be paramagnetic. Measured molar conductance showed that the complexes 2 and 4 are non-electrolytes and complexes 3, 5 and 6 are electrolytes. Besides, some metal complexes have shown very good antibacterial and antifungal activities.Keywords: Bis(2,4,4-trimethylpentyl) monothiophosphinic acid; Biological activity.© 2012 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.doi: http://dx.doi.org/10.3329/jsr.v4i2.9366 J. Sci. Res. 4 (2), 427-435 (2012)

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Section: Magnetic Susceptibility and Electronic Spectramentioning

confidence: 96%

Section: Infrared Spectramentioning

confidence: 99%

Section: Magnetic Susceptibility and Electronic Spectramentioning

confidence: 99%

Section: Magnetic Susceptibility and Electronic Spectramentioning

confidence: 99%

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Physico-Chemical Characterization and Biological Screening of Cyanex 302 complexes

et al. 2012

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“…Lomefloxacin was also coordinated with different metal ions Mn(II), Co(II), Ni(II), Cu(II), and Zn(II)) and investigated for the biological activity along with the parent free drug. As cytotoxic agents, lomefloxacin and its cobalt and zinc complexes 58 represented a remarkable activity with the order of potency: cobalt complex > lomefloxacin > zinc complex (IC 50 , 11.2, 14.0 and 43.1 µg/mL, respectively) …”

Section: Fluoroquinolone Metal Ion Complexes With Anticancer Activitymentioning

confidence: 99%

Towards anticancer fluoroquinolones: A review article

Abdel-AAl

Abdel‐Aziz

Shaykoon

et al. 2019

Archiv der Pharmazie

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Different studies about the anticancer potential of several medically used antibacterial fluoroquinolones have been established. Fluoroquinolone derivatives, like some anticancer drugs, such as doxorubicin, can achieve antitumor activity via poisoning of type II human DNA topoisomerases. Interestingly, structural features required for the anticancer activity of quinolones have been determined. Most of the chemical modifications required to convert antibacterially acting fluoroquinolones into their anticancer analogs were at position 7 and the carboxylic group at position 3. This review highlights the antitumor potential of fluoroquinolones in general and summarizes the chemical modifications carried out on fluoroquinolones to become anticancer agents. Moreover, the review gives a quick recap on metal ion chelates with fluoroquinolones and their substantial role in topoisomerase poisoning and antitumor potential improvement. Hence, it should be highly interesting for researchers attempting to design and synthesize novel anticancer fluoroquinolone candidates. K E Y W O R D S anticancer, DNA topoisomerase, metal ion complexes, quinolones Arch Pharm Chem Life Sci. 2019;352:1800376.wileyonlinelibrary.com/journal/ardp

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Synthesis, characterization and in vitro antimicrobial and anti‐breast cancer activity studies of metal complexes of novel pentadentate azo dye ligand

Mahmoud

Sayed

Mohamed

2016

Applied Organom Chemis

Self Cite

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A new azo dye with N3O2 donor set of atoms has been synthesized via coupling reaction of 2,6-diaminopyridine with p-methoxybenzaldehyde. The molecular and electronic structure of the azo dye ligand (L) was optimized theoretically and the quantum chemical parameters were calculated. Molecular docking was used to predict the binding between L and the receptors of breast cancer mutant 3hb5-oxidoreductase, crystal structure of Escherichia coli (3 T88) and crystal structure of Staphylococcus aureus (3q8u). The newly synthesized L was used for complex formation with Cr(III), Mn(II), Fe(III), Co.(II), Ni(II), Cu(II), Zn(II) and Cd (II) ions. The nature of bonding and the stoichiometry of L and its mononuclear complexes were deduced from elemental analyses, spectroscopic, magnetic susceptibility, molar conductance, electron spin resonance and conductivity measurements, thermogravimetric analyses and powder X-ray diffraction. Elemental analysis data show that the complexes have composition of ML type with an octahedral geometry for all the complexes. The activation thermodynamic parameters were calculated. The prepared azo dye and its metal complexes were tested against various Gram-positive and Gram-negative bacteria and a fungus. Most complexes exhibit antibacterial and antifungal activities against these organisms. Anticancer evaluation studies against standard breast cancer cell line were performed using various concentrations. The activity index was calculated.

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Ligational behaviour of lomefloxacin drug towards Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Th(IV) and UO2(VI) ions: Synthesis, structural characterization and biological activity studies

Cited by 75 publications

References 42 publications

Physico-Chemical Characterization and Biological Screening of Cyanex 302 complexes

Physico-Chemical Characterization and Biological Screening of Cyanex 302 complexes

Towards anticancer fluoroquinolones: A review article

Synthesis, characterization and in vitro antimicrobial and anti‐breast cancer activity studies of metal complexes of novel pentadentate azo dye ligand

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