Ligational and biological studies of Fe(III), Co(II), Ni(II), Cu(II), and Zr(IV) complexes with carbamazepine as antiepileptic drug

Abstract

Carbamazepine (CBZ) is considered to be the preferred drug for fractional seizures and may also use in the prevention of primary generalized tonic–clonic seizures. The chelates of CBZ with Fe(III), Co(II), Ni(II), Cu(II), and Zr(IV) were designed and characterized on the basis of elemental analysis, FT‐IR, 1H NMR, UV‐visible, mass spectra, thermal analysis (TG, DTG, and DTA), molar conductivity, and magnetic moment. IR spectra emphasize that CBZ acts as a neutral bidentate ligand with metal ions through amide oxygen and amino nitrogen. UV‐visible spectra and magnetic moment demonstrate that all chelates have geometric octahedral structures. Complexes thermal behavior is systematically analyzed employing TG and DTA technicality. TG findings signalize that water molecules (hydrated and coordinated) are extracted the first and second phases, while CBZ ligand is splitted in the second and subsequent steps. From the DTA curves, the obtained data reflect that the degradation processes are endothermic or exothermic peaks. Assorted thermodynamic factors are calculated, and the results are explicated. Antimicrobial activity was examined against two Gram‐positive bacteria (Staphylococcus aureus and Bacillus subtilis) and two Gram‐negative bacteria (Escherichia coli and Pseudomonas aeuroginosa). Anti‐fungal efficacy of the compounds has been tested. The Co(II) complex was highly significant against the antifungal Candida albicans and significantly against Escherichia coli, Staphylococcus aureus, and Bacillus subtilis.

Designing covalent organic frameworks with Co-O4 atomic sites for efficient CO2 photoreduction

“…In order to determine whether the water molecules in Co(NO 3 ) 2 ·6H 2 O participated in Co-O coordination, thermogravimetric analysis (TGA) of the two Co-COFs was conducted. Interestingly, thermal peaks of crystalline water 41 – 43 were observed at 217 and 249 °C from the first derivative of the TGA curves for Co-2,3-DHTA-COF and Co-TP-COF, respectively (Supplementary Fig. 12 ), suggesting that water molecules in Co(NO 3 ) 2 ·6H 2 O existed in the Co-COFs.…”

First Report on Several NO-Donor Sets and Bidentate Schiff Base and Its Metal Complexes: Characterization and Antimicrobial Investigation

“…A vibration band occurring at 1612 cm −1 was credited to the stretching vibration of the C=N bond in the azomethine group of the L compound. However, this band shifted to lower wavenumbers in the chelate spectra around 1601 cm −1 ; this demonstrated the azomethine nitrogen involvement in the coordination [37][38][39][40][41]. The ν(Zr=O) in complex (4) was found as a medium band at 832 cm −1 [42].…”

Novel Enrofloxacin Schiff Base Metal Complexes: Synthesis, Spectroscopic Characterization, Computational Simulation and Antimicrobial Investigation against Some Food and Phyto-Pathogens

“…The IR spectra of complexes display discrete differences when compared to the H 2 Erx-en spectrum, signifying complexation. The IR spectra of all complexes containing hydration and or coordination water molecules reveal bands at 3437-3410 cm −1 , related to the v(O-H) vibration mode of the water molecules [21][22][23]. The prominence of bands in the spectra of all complexes approximately 3350, 840, and 600 cm −1 was ascribed to v(O-H), the rocking and wagging vibration for coordinated water molecules [24,25].…”