Ligation of intersphincteric fistula tract (LIFT) to treat anal fistula: systematic review and meta-analysis

Hong, Kwang Dae; Kang, Seok Ho; Kalaskar, Sudhir N.; Wexner, Steven D.

doi:10.1007/s10151-014-1183-3

Cited by 144 publications

(97 citation statements)

References 29 publications

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“…As described, the results were similar among the techniques in terms of both postoperative recurrence and incontinence. Several published studies showed that LIFT has provided good results particularly in terms of postoperative continence [53]. However, to our knowledge, only one RCT comparing LIFT to ERAF has been published [54].…”

Section: Discussionmentioning

confidence: 97%

Fistulotomy or fistulectomy and primary sphincteroplasty for anal fistula (FIPS): a systematic review

et al. 2015

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There is still no clear consensus about surgical treatment of anal fistulas. Fistulotomy or fistulectomy and primary sphincter reconstruction is still regarded with skepticism. The aim of this systematic review was to evaluate the evidence in the literature supporting the use of this technique in the treatment of complex anal fistulas. MEDLINE, EMBASE and Cochrane Library databases were searched for the period between 1985 and 2015. The studies selected were peer-reviewed articles, with no limitations concerning the study cohort size, length of the follow-up or language. Technical notes, commentaries, letters and meeting abstracts were excluded. The major endpoints were the technique adopted, clinical efficacy, changes at anorectal manometry and assessment of quality of life after the procedure. Fourteen reports (666 patients) satisfied the inclusion criteria. The quality of the studies was low. Some differences about the surgical technique emerged; however, after a weighted average duration of follow-up of 28.9 months, the overall success rate was 93.2 %, with a low morbidity rate. The overall postoperative worsening continence rate was 12.4 % (mainly post-defecation soiling). In almost all cases, the anorectal manometry parameters remained unchanged. The quality of life, when evaluated, improved significantly. Fistulotomy or fistulectomy and primary sphincteroplasty could be a therapeutic option for complex anal fistula. Success rates were very high and the risk of postoperative fecal incontinence was lower than after simple fistulotomy. Well-designed trials are needed to support the inclusion of this technique in a treatment algorithm for the management of complex anal fistulas.

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Section: Discussionmentioning

confidence: 97%

Fistulotomy or fistulectomy and primary sphincteroplasty for anal fistula (FIPS): a systematic review

et al. 2015

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“…Second, AFP for CD appears to have inferior results compared with AFP for non-CD fistulae. This discrepancy was also demonstrated with other techniques including the advancement flap repair study of Jarrar et al [23], which showed 87% healing in CD and 98% for non-CD fistula, and the LIFT procedure healing rate of 76.4% for all patients compared with 60% healing reported by Gingold et al [10] which specifically evaluated LIFT in CD fistula [24]. The difference between CD and non-CD fistula may be related to multiple fistula tracts in CD or persistent proctitis, which interfere with healing.…”

Section: Discussionmentioning

confidence: 88%

The anal fistula plug in Crohn's disease patients with fistula‐in‐ano: a systematic review

Nasseri¹,

Cassella²,

Berns³

et al. 2016

Colorectal Disease

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The studies suggest that the use of an AFP in patients with Crohn's disease is a safe procedure with reasonable success, little morbidity and a low risk of incontinence. The current literature is limited by a number of factors, including small study cohorts, grouping of fistulae in Crohn's disease with other types of anal fistula, short and highly variable follow-up times and multiple confounding factors such as number of fistula tracts, use of preoperative steroids or immunosuppressants, previous use of setons and variation in surgical technique.

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“…The internal opening may be closed and the distal portion of the tract is curetted but remains open to facilitate drainage. Promising but varied rates of healing between 57% and 94% have been reported, but there is very limited data dedicated to CD patients (5,78,(90)(91)(92)(93).…”

Section: Resultsmentioning

confidence: 99%

MR Imaging of Perianal Crohn Disease

et al. 2017

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Ligation of intersphincteric fistula tract (LIFT) to treat anal fistula: systematic review and meta-analysis

Cited by 144 publications

References 29 publications

Fistulotomy or fistulectomy and primary sphincteroplasty for anal fistula (FIPS): a systematic review

Fistulotomy or fistulectomy and primary sphincteroplasty for anal fistula (FIPS): a systematic review

The anal fistula plug in Crohn's disease patients with fistula‐in‐ano: a systematic review

MR Imaging of Perianal Crohn Disease

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