Ligation-Based High-Performance Mimetic Enzyme Sensing Platform for Nucleic Acid Detection
Xinrong Yan,
Peiru Yang,
Dehui Qiu
et al.
Abstract:G-quadruplex (G4)/hemin DNAzyme is a promising candidate to substitute horseradish peroxidase in biosensing systems, especially for the detection of nucleic acids. However, the relatively suboptimal catalytic capacity limits its potential applications. This makes it imperative to develop an ideal signal for the construction of highly sensitive biosensing platforms. Herein, we integrated a novel chimeric peptide-DNAzyme (CPDzyme) with the ligase chain reaction (LCR) for the costefficient and highly sensitive de… Show more
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