Ligands Containing of a C=O and an –Nh–R Adjacent to the Oxime Group and their Cobalt(Ii), Nickel(Ii) and Copper(Ii) Complexes

Abstract

Ligands having a C=O group and an -NH-R group adjacent to the oxime group have been prepared from ω-chloroisonitrosoacetophenone and aniline or aniline derivatives in the presence of NaHCO 3 . The Ni(II), Cu(II) and Co(II) complexes of the synthesised ligands have been prepared and characterised. The ligands are proposed to coordinate to the metal ions via the oxime oxygen and amide nitrogen atoms. Thermal analyses data reveals that the water in the complexes is non-coordinated to the metal ions. Binuclear and polymeric structures are suggested for all complexes. The complexes showed an antiferromagnetic effect.

Screening and evaluation of antioxidant activity of some amido-carbonyl oxime derivatives and their radical scavenging activities

“…In this assay, oximes are interfered with the formation of Fe 2+ and Fe 3+ -complex since they have chelating activity to capture Fe 2+ ion before ferrozine (oxime + Fe 2+ → oximeFe 2+ complex). The oxime ligands are good chelating agents for metal ions [1,27]. The metal chelating effects of the oximes were found as concentration-dependent.…”

“…The syntheses of the oxime derivatives 1-5, 7-10 used in this work, have been described previously by Tas and et al [27,[36][37][38][39][40][41][42]. Compound 6 was newly prepared for this work from the reaction of -chloroisonitrosoacetophenone with 3,4 dimethylaniline using Tas' method [27].…”

“…Compound 6 was newly prepared for this work from the reaction of -chloroisonitrosoacetophenone with 3,4 dimethylaniline using Tas' method [27].…”

“…While carbonyl oximes have a carbonyl (C=O) group in the -position to the oxime group (Figure 1), amide-oximes have a -NH-R group in the -position to the oxime group ( Figure 1). [1,2,4] Carbonyl oximes and amide-oximes have been studied extensively, but work on amido-carbonyl oximes (Figure 1), which have -C=O and -NH-R' groups in the same molecule in the -position to the oxime group is scantily described [27].…”

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“…5,6 Previous works reported that oxime derivatives possessed insecticidal, miticidal, nematocidal, antiradical, antioxidant, antiepileptic, antihyperglycemic, antimicrobial, antidote, anticarcinogenic and anti-HIV activities. [7][8][9][10][11][12][13][14][15][16][17][18] We synthesized a series of novel phenylacetamidine based amido-carbonyl oximes (C1-C9). Structures of the compounds characterized by 1 H-NMR, IR spectroscopy, and X-ray crystallography.…”