Ligandenaustauschreaktionen an Kupfer(II)‐Komplexen mit Harnstoffliganden: Synthesen, Strukturen, EPR‐Spektroskopie

Gruschinski, Sina; Rodenstein, Axel

doi:10.1002/zaac.201200044

Zeitschrift anorg allge chemie

2012

DOI: 10.1002/zaac.201200044

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Ligandenaustauschreaktionen an Kupfer(II)‐Komplexen mit Harnstoffliganden: Synthesen, Strukturen, EPR‐Spektroskopie

Sina Gruschinski

Axel Rodenstein

Abstract: The synthesis of copper(II) and nickel(II) complexes of N,N-HL 4 and N,N-diethyl-N'-benzimidoylthiourea H 2 L 5 and the crystal structures of HL 2 , [Cu(L 2 ) 2 ] and [Ni(HL 5 ) 2 ] are reported. All Cu II complexes were investigated by EPR spectroscopy in liquid and frozen solutions. The Cu II complex [Cu(HL 5 ) 2 ] was additionally studied as diamagnetically diluted powder system

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Cited by 2 publications

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Syntheses, Structures, and Bioactivity Evaluation of some Transition Metal Complexes with Aroylbis(N,N‐diethylthioureas) Derived from Natural Compounds

Pham

Nguyễn³

et al. 2021

Zeitschrift anorg allge chemie

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Two novel benzoylthioureas derived from gallic acid, (tri-Oacetyl)galloyl-N,N-diethylthiourea HL 1 , and cinnamic acid, cinnamoyl-N,N-diethylthiourea HL 2 have been successfully prepared and characterized by means of elemental analysis, IR, NMR, high-resolution MS, and X-ray crystallography. The organic ligands react with Ni(AcO) 2 and Cu(AcO) 2 in MeOH under formation of bis-complexes with the compositions of [M(L) 2 ] (M=Ni 2 + , Cu 2 + ; L=L 1 , L 2 ). Similar reactions with Co(AcO) 2 , however, result in Co(III) tris-complexes [Co(L) 3 ] (L=L 1 , L 2 ) with the metal ions oxidized presumably by atmospheric dioxygen. X-ray crystallography and spectroscopic characterization reveal a cis square-planar coordination in the bis-complexes and facial octahedral geometry in the tris-complexes. In all of metal complexes, the deprotonated organic compounds ({L 1 } À and {L 2 } À ) serve as (S,O)-bidentate ligands. The ligand HL 1 and its Ni(II) and Cu(II) complexes exhibit weak antiproliferative effects on the human MCF7 breast and HepG2 liver cancer cells with IC 50 values in the range of 60-115 μM. Surprisingly, the triscomplex [Co(L 1 ) 3 ] exhibits high cytotoxicity with IC 50 values of 22.23 � 1.58 μM for MCF7 and 28.30 � 3.09 μM for HepG2 cancer cells. The activity against MCF7 cells is even more than that of cisplatin under the same conditions.

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Syntheses, Structures, and Bioactivity Evaluation of some Transition Metal Complexes with Aroylbis(N,N‐diethylthioureas) Derived from Natural Compounds

Pham

Nguyễn³

et al. 2021

Zeitschrift anorg allge chemie

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Syntheses, Structures and Cytotoxicity of Cu(II) Complexes with α‐Amino acid derived Benzamidines

Nguyen

Pham

2022

Zeitschrift anorg allge chemie

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N-(diethylthiocarbamoyl)benzimidoyl chloride reacts with methyl esters of glycine, L-alanine, L-valine under formation of proligands 1 which undergo de-esterification in reactions with Cu(CH 3 COO) 2 and finally form complexes 2 with the composi-(2 c). In all complexes, Cu(II) ion is coordinated by a dianion {L 2À } via its (O,N,S) donor set and a bridging carboxylate O atom, and thus, adopts a distorted square-planar coordination sphere. Treatment of complexes 2 with equimolar amounts of o-phenanthroline results in the formation of square pyramidal ternary complexes with the compositions of [Cu(L)phen] (L = Lgly, L-ala, L-val) (3). Antiproliferative effects of the compounds on MCF-7 and Hep-G2 cancer cells were studied. Generally, the ternary complexes 3 are more active than the complexes 2 and the pro-ligands 1. In each series of compounds, the derivatives of L-valine show higher cytotoxicity than those of L-alanine and glycine.

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Ligandenaustauschreaktionen an Kupfer(II)‐Komplexen mit Harnstoffliganden: Synthesen, Strukturen, EPR‐Spektroskopie

Cited by 2 publications

References 39 publications

Syntheses, Structures, and Bioactivity Evaluation of some Transition Metal Complexes with Aroylbis(N,N‐diethylthioureas) Derived from Natural Compounds

Syntheses, Structures, and Bioactivity Evaluation of some Transition Metal Complexes with Aroylbis(N,N‐diethylthioureas) Derived from Natural Compounds

Syntheses, Structures and Cytotoxicity of Cu(II) Complexes with α‐Amino acid derived Benzamidines

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