Ligand-regulated three-photon AIE properties of manganese(ii) complexes for photodynamic therapy

Abstract

With the advantages of deeper penetration depth and lower biological damage, multi-photon AIE probes are widely used in the field of multi-photon therapy. We develop a series of carbazole terpyridine...

Near-infrared AIE-active phosphorescent iridium(iii) complex for mitochondria-targeted photodynamic therapy

“…The fluorescence of PSs with aggregation-induced emission (AIE) properties is enhanced under the aggregation state, which could well solve the difficulties of traditional PSs in the clinical application of image-guided PDT. [30][31][32][33] Mitochondria-targeted metal-based PSs have been widely reported by many research groups, but their development is greatly limited due to the short irradiation wavelengths, which are generally less than 500 nm, severe photodamage, and low penetration depth. [34][35][36] It is well known that phosphorescent complexes with near-infrared (NIR) emission can not only increase the penetration depth of excitation light to biological tissue but also effectively avoid the interference of self-fluorescence of living tissue in vivo optical imaging.…”

Recent advances in aggregation‐induced emission–active type I photosensitizers with near‐infrared fluorescence: From materials design to therapeutic platform fabrication

“…AIE-active PSs generally have the advantages of bright fluorescence and higher ROS efficiency at aggregation but weak fluorescence and lower or even no ROS generation in the unimolecular state. Up to now, plenty of AIEactive PSs with multiple functions such as NIR-II fluorescence [16], two/three-photon excitation [17][18][19][20], acidic response [21], photoactivation [22], and use in synergistic therapies of chemotherapy [23],…”

“…AIE‐active PSs generally have the advantages of bright fluorescence and higher ROS efficiency at aggregation but weak fluorescence and lower or even no ROS generation in the unimolecular state. Up to now, plenty of AIE‐active PSs with multiple functions such as NIR‐II fluorescence [16], two/three‐photon excitation [17–20], acidic response [21], photo‐activation [22], and use in synergistic therapies of chemotherapy [23], photothermal treatment [24], and immunization [25] were developed and showed great efficiency in the fields of anticancer and antibiosis. However, hypoxia of the TEM makes PDT not produce persistent ROS, which seriously restricts its outcome.…”