Ligand‐gated ion channels as potential biomarkers for ADT‐mediated cognitive decline in prostate cancer patients
Shiv Verma,
Vaibhav Singh,
VijayKrishna Nagampalli
et al.
Abstract:Men with prostate cancer are at increased risk of developing cognitive decline by the use of second‐generation androgen signaling inhibitors. To date, reliable and sensitive biomarkers that could distinguish men at high risk of cognitive dysfunction under androgen deprivation therapy (ADT) have not been characterized. We used high‐throughput transcriptional profiling utilizing human prostate cancer cell culture models mimicking ADT, biomarker selection using minimal common oncology data elements‐cytoscape, and… Show more
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