Ligand-functionalized nanoliposomes for targeted delivery of galantamine

Mufamadi, Maluta Steven; Choonara, Yahya E.; Kumar, Pradeep; Modi, Girish; Naidoo, Dinesh; Vuuren, Sandy van; Ndesendo, Valence M. K.; Toit, Lisa C. du; Iyuke, Sunny E.; Pillay, Viness

doi:10.1016/j.ijpharm.2013.03.037

Cited by 41 publications

(20 citation statements)

References 54 publications

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“…The lactoferrin (Lf )-conjugated PEG-co-PCL nanoparticles are found to enhance the cellular accumulation in 16HBE14o-cells of the brain (cerebellum, olfactory tract, olfactory bulb, and hippocampus) through both caveolae-/clathrin-mediated endocytosis, and to enhance the biodistribution of protein and peptide in different parts of the brain by noninvasive nasal brain delivery in AD . The peptide-ligand functionalized nanoliposomes were produced to facilitate the neuronal cell uptake of galantamine-loaded nanoliposomes, and the final formulation aided neuron accumulation, confirmed by fluorometry and confocal microscopy (Mufamadi et al 2013). Odorranalectin (OL) (small non-immunogenic peptide)conjugated modified cubosomes, prepared by incorporating maleimide-PEG-oleate and Gly14-Humanin (S14G-HN), serve as a model drug for AD.…”

Section: Importance Of Surface-modified Nanoparticlesmentioning

confidence: 97%

Recent prospective of surface engineered Nanoparticles in the management of Neurodegenerative disorders

Singh

Kapahi

Rashid

et al. 2015

Artificial Cells, Nanomedicine, and Biotechnology

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Clinically, the therapeutic outcomes in neurodegenerative disorders (NDs) by drug treatment are very limited, and the most insurmountable obstacle in the treatment of NDs is the blood-brain barrier (BBB), which provides the highest level of protection from xenobiotics. A great deal of attention still needs to be paid to overcome these barriers, and surface-engineered polymeric nanoparticles are emerging as innovative tools that are able to interact with the biological system at a molecular level for the desired response. The present review covers the potential importance of surface-structure-engineered nanoparticles to overcome the BBB for good bioavailability, and the evaluation of drug therapy in NDs.

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Section: Importance Of Surface-modified Nanoparticlesmentioning

confidence: 97%

Recent prospective of surface engineered Nanoparticles in the management of Neurodegenerative disorders

Singh

Kapahi

Rashid

et al. 2015

Artificial Cells, Nanomedicine, and Biotechnology

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“…It has been previously demonstrated via confocal fluorescence microscopy that the ligand-functionalized nanolipobubbles were effectively localized within the PC12 neuronal cells whereas non-functionalized nanolipobubbles showed weak or no FITC fluorescence activity (41). These results suggested that the increase in fluorescence activity in PC12 neuronal cells was due to the engineered peptides on the surface of the NLPs, which promoted intracellular uptake via SEC-R in a mediated manner (41). Figure 12 depicts a topographical view of the fluorescence pseudo threedimensional images of the PC12 neuronal cells incubated with the nanocomposite hydrogel.…”

Section: Optical Bio-imaging Of the Fluorescence-labeled Nanocompositmentioning

confidence: 99%

“…The first phase of this study involved the modification of previously synthesized functionalized nanoliposomes (40,41) by incorporating gases such as nitrogen (N 2 ), medical carbon dioxide (CO 2 ), and perfluorocarbon (PFC) [sulfur hexafluoride (SF 6 )] to form nanolipobubbles. The nanolipobubbles have been designed to provide effective intracellular delivery of drug into PC12 neuronal cells via specificity for over-expressed surface receptors such as Serpin Enzyme Complex-Receptor (SEC-R) for the targeted management of neurodegenerative disorders such as Alzheimer's disease (AD) (41). The second phase involved the synthesis of a GA cross-linked hydrogel network using a blend of CS, EU, and PVA/PEO at varying concentrations.…”

Section: Introductionmentioning

confidence: 99%

Functionalized Nanolipobubbles Embedded Within a Nanocomposite Hydrogel: a Molecular Bio-imaging and Biomechanical Analysis of the System

et al. 2016

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The purpose of this study was to explore the use of molecular bio-imaging systems and biomechanical dynamics to elucidate the fate of a nanocomposite hydrogel system prepared by merging FITC-labeled nanolipobubbles within a cross-linked hydrogel network. The nanocomposite hydrogel system was characterized by size distribution analysis and zeta potential as well as shears thinning behavior, elastic modulus (G'), viscous loss moduli (G"), TEM, and FTIR. In addition, molecular bio-imaging via Vevo ultrasound and Cell-viZio techniques evaluated the stability and distribution of the nanolipobubbles within the cross-linked hydrogel. FITC-labeled and functionalized nanolipobubbles had particle sizes between 135 and 158 nm (PdI = 0.129 and 0.190) and a zeta potential of -34 mV. TEM and ultrasound imaging revealed the uniformity and dimensional stability of the functionalized nanolipobubbles pre- and post-embedment into the cross-linked hydrogel. Biomechanical characterization of the hydrogel by shear thinning behavior was governed by the polymer concentration and the cross-linker, glutaraldehyde. Ultrasound analysis and Cell-viZio bio-imaging were highly suitable to visualize the fluorescent image-guided nanolipobubbles and their morphology post-embedment into the hydrogel to form the NanoComposite system. Since the nanocomposite is intended for targeted treatment of neurodegenerative disorders, the distribution of the functionalized nanolipobubbles into PC12 neuronal cells was also ascertained via confocal microscopy. Results demonstrated effective release and localization of the nanolipobubbles within PC12 neuronal cells. The molecular structure of the synthetic surface peptide remained intact for an extended period to ensure potency for targeted delivery from the hydrogel ex vivo. These findings provide further insight into the properties of nanocomposite hydrogels for specialized drug delivery.

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“…Therapeutic strategies are targeting their efforts towards the inhibition of acetylcholinesterase or an agonist of cholinergic receptors [181] using molecules such as rivastigmine incorporated into liposomes [182,183], or polymer [184] or galantamine [185]. This acetylcholine decrease was used as an in vivo biosensor system using carboxylated multi-walled CNTs and zirconium oxide NP onto which were co-immobilized acetylcholinesterase and choline oxidase and deposited on glassy carbon electrodes [186].…”

Section: Therapeutic Strategies Using Nanoparticles In Ndmentioning

confidence: 99%

The Ins and Outs of Nanoparticle Technology in Neurodegenerative Diseases and Cancer

Wilson¹,

Magnaudeix²,

Naves³

et al. 2015

CDM

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Ligand-functionalized nanoliposomes for targeted delivery of galantamine

Cited by 41 publications

References 54 publications

Recent prospective of surface engineered Nanoparticles in the management of Neurodegenerative disorders

Recent prospective of surface engineered Nanoparticles in the management of Neurodegenerative disorders

Functionalized Nanolipobubbles Embedded Within a Nanocomposite Hydrogel: a Molecular Bio-imaging and Biomechanical Analysis of the System

The Ins and Outs of Nanoparticle Technology in Neurodegenerative Diseases and Cancer

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