Ligand‐Free Nickel‐Catalyzed Carbonyl Addition with Organoborons
Sha‐Sha Wu,
Xiaodong Ye,
Zi‐Chao Wang
et al.
Abstract:Carbonyl addition serves as a strategically straightforward and versatile approach for synthesizing alcohols, which are often encountered within bioactive molecules. Herein, we present a ligand‐free, nickel‐catalyzed carbonyl addition process using organoboron reagents. This method enables efficient arylation of readily available ketones or aldehydes, affording a variety of tertiary and secondary alcohols. Key highlights of this protocol include the obviation of external ligands and the tolerance to many funct… Show more
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