Ligand Binding to the Cell‐Surface Receptor for Reovirus Type 3 Alters Schwann Cell Growth and Function

Cohen, Jeffrey A.; Williams, William V.; More, Kenneth; Sehdev, Harish M.; Davies, James G.; Greene, Mark I.

doi:10.1111/j.1749-6632.1990.tb42432.x

Cited by 1 publication

(1 citation statement)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4) Studies employing synthetic peptides demonstrated that these domains mediate the binding of the o1 protein and 87.92.6 antibody to both the neutralizing anti-al antibody 9B.G5 and to the Reo3R (21). These regions also mediate functional consequences of Reo3R-ligand interaction including down-modulation of Reo3R and inhibition of target cell growth (22,31). The present studies demonstrate that these domains also mediate the observed effects on oligodendrocyte differentiation.…”

Section: Resultsmentioning

confidence: 51%

Ligand binding to the cell surface receptor for reovirus type 3 stimulates galactocerebroside expression by developing oligodendrocytes.

Cohen

Williams

Weiner

et al. 1990

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Viruses utilize normal cell surface structures as attachment sites. Interaction of viral components with these structures may alter target cell growth. In the present study, the expression and function of the cell surface receptor for reovirus type 3 (Reo3R) was studied in neonatal rat optic nerve Myelination in the central nervous system involves the migration and proliferation of oligodendrocyte precursors, the coordinated synthesis of myelin components, and morphological adaptation of the oligodendrocyte plasma membrane to form the myelin sheath. The regulation of this complex process probably involves autonomous mechanisms intrinsic to the oligodendrocyte and its precursors; interactions of oligodendrocytes with the substratum, axons, and other glia; and the actions of soluble regulatory factors. Neonatal rat optic nerve glial cultures provide a useful model system with which to dissect these phenomena (1). In this system, 0-2A glial progenitor cells have been identified, which differentiate into oligodendrocytes and type 2 (fibrous) astrocytes. Type 1 (protoplasmic) astrocytes, also present in these cultures, probably arise from a separate lineage. Each of these cell types can be identified by morphological criteria and by the expression of characteristic antigenic markers

show abstract

Section: Resultsmentioning

confidence: 51%