2022
DOI: 10.1134/s0006350922030162
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Ligand Binding to Nucleic Acids in Solution and on Microchips

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“…(iii). Ligand binding to nucleic acids in solution and on microchips (Nechipurenko et al 2020): The equilibrium binding of ligands (proteins, biologically active compounds, and oligonucleotides) to nucleic acids underlies many processes in the living cell. Model study and physical adsorption theory methods can be used to quantitatively describe the binding in the cases where a ligand occupies an extended region on DNA and where cooperative interactions occur between adsorbed ligand molecules.…”
Section: Biophysicsmentioning
confidence: 99%
“…(iii). Ligand binding to nucleic acids in solution and on microchips (Nechipurenko et al 2020): The equilibrium binding of ligands (proteins, biologically active compounds, and oligonucleotides) to nucleic acids underlies many processes in the living cell. Model study and physical adsorption theory methods can be used to quantitatively describe the binding in the cases where a ligand occupies an extended region on DNA and where cooperative interactions occur between adsorbed ligand molecules.…”
Section: Biophysicsmentioning
confidence: 99%