Ligand-based backbone modifications for metal-chelating nucleic acids

Knagge, Megan M.; Wilker, Jonathan J.

doi:10.1039/b704741j

Cited by 6 publications

(3 citation statements)

References 50 publications

(47 reference statements)

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“…Pt 2+ coordination can increase the stability of such a duplex [61]. Interesting work published by Sugimoto demonstrated the use of metals to assemble higher order structures [62].…”

Section: Dna Modified With Terpyridine Bipyridine and Phenanthrolinementioning

confidence: 97%

DNA modified with metal complexes: Applications in the construction of higher order metal–DNA nanostructures

Yang

Metera

Sleiman

2010

Coordination Chemistry Reviews

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“…Pt 2+ coordination can increase the stability of such a duplex [61]. Interesting work published by Sugimoto demonstrated the use of metals to assemble higher order structures [62].…”

Section: Dna Modified With Terpyridine Bipyridine and Phenanthrolinementioning

confidence: 97%

DNA modified with metal complexes: Applications in the construction of higher order metal–DNA nanostructures

Yang

Metera

Sleiman

2010

Coordination Chemistry Reviews

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“…A metal-binding bipyridyl unit was inserted into a nucleotide oligomer by Knagge and Wilker. 23 Duplexes with unmodified strands were stabilised to different extents by the insertion of different metal ions either through their cationic charge or hydrogen bonding, enabling the possibility of tuning duplex stability.…”

Section: Backbone Modificationsmentioning

confidence: 99%

Bioinspired organic chemistry

Webb

2008

Annu. Rep. Prog. Chem., Sect. B: Org. Chem.

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“…The incorporation of unnatural ligating groups for metal ions into DNA facilitates the formation of these nucleic acid/metal ion hybrid materials. Such ligands may be incorporated as base modified nucleotides − or as non-nucleosidic ligands ,− . Ligands may be appended to either the 5′ or 3′-termini of DNA − or, alternately, incorporated in midsequence of the DNA ,,, .…”

Section: Introductionmentioning

confidence: 99%

Binding of Europium(III) to a Non-Nucleosidic Phenanthroline Linker in DNA

et al. 2010

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Eu(III) complexes of DNA containing a non-nucleosidic linker, a derivative of 1,10-phenanthroline-2,6-dicarboxamide (Q), are studied with the goal of forming novel lanthanide ion binding sites that are incorporated in the backbone of DNA. One oligonucleotide is short and unstructured (TTTQTTT (QT6)) and the other (5'-AGCTCGGTCAQCGAGAGTGCA-3' (SQ)) is studied both in single-stranded form and in the presence of a partially complementary DNA strand. Luminescence spectroscopy studies show that Eu(III) binds to SQ, QT6, AQB, or QB 1100-, 56-, 23-, or 27-fold more tightly, respectively, than to a simple 1,10-phenanthroline-2,6-dicarboxamide ligand (Q1). Direct excitation and phenanthroline sensitized luminescence spectroscopy supports binding of Eu(III) to the phenanthroline linker in QT6 and in double-stranded DNA formed from SQ and partially complementary sequences that place Q in a bulge-like position. Eu(III) hydration numbers range from 3 to 5 when bound to the phenanthroline moiety in modified DNA, consistent with binding to the tetradentate linker and, in some cases, coordination to other groups in the DNA. Thermal melting experiments show that Q in a bulge-like structure stabilizes double-stranded DNA and that Eu(III) binding does not markedly affect the stability of the duplex.

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Ligand-based backbone modifications for metal-chelating nucleic acids

Abstract: Ligands were incorporated into the backbone of DNA for nucleoside replacements, and the binding of metal ions, such as Cu2+, Pt2+ and Pd4+, was shown to influence stability of the resulting duplexes.

Cited by 6 publications

References 50 publications

DNA modified with metal complexes: Applications in the construction of higher order metal–DNA nanostructures

DNA modified with metal complexes: Applications in the construction of higher order metal–DNA nanostructures

Bioinspired organic chemistry

Binding of Europium(III) to a Non-Nucleosidic Phenanthroline Linker in DNA

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