Lifetime Stressful Events Associated with Alzheimer's Pathologies, Neuroinflammation and Brain Structure in a Risk Enriched Cohort
Eleni Palpatzis,
Muge Akinci,
Pablo Aguilar‐Dominguez
et al.
Abstract:ObjectiveAlong with the known effects of stress on brain structure and inflammatory processes, increasing evidence suggest a role of chronic stress in the pathogenesis of Alzheimer's disease (AD). We investigated the association of accumulated stressful life events (SLEs) with AD pathologies, neuroinflammation, and gray matter (GM) volume among cognitively unimpaired (CU) individuals at heightened risk of AD.MethodsThis cross‐sectional cohort study included 1,290 CU participants (aged 48–77) from the ALFA coho… Show more
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