Lifetime risk of renal replacement therapy in Europe: a population-based study using data from the ERA-EDTA Registry

Brand, Jan J.A.J.G. Van Den; Pippias, Maria; Stel, Vianda S.; Caskey, Fergus; Collart, Frédéric; Finne, Patrik; Heaf, James; Jaïs, Jean Philippe; Kramar, Reinhard; Massy, Ziad A.; Meester, Johan M J J. De; Traynor, Jamie P.; Reisæter, Anna Varberg; Jf, Wetzels; Jager, Kitty J.

doi:10.1093/ndt/gfw392

Cited by 13 publications

(16 citation statements)

References 20 publications

(30 reference statements)

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“…Our study showed considerable sex-dependent differences in the lifetime risk of ESKD in Japan. This is in line with previous studies from other countries [12][13][14] that have found that men have higher lifetime risks of ESKD than women. Using cohort data of adults residing in Alberta, Canada, the lifetime risk of ESKD among those without ESKD at age 40 years was estimated to be 2.66% (95% CI 2.57-2.75%) for men and 1.76% (95% CI 1.69-1.83%) for women [12].…”

Section: Discussionsupporting

confidence: 93%

“…Using cohort data of adults residing in Alberta, Canada, the lifetime risk of ESKD among those without ESKD at age 40 years was estimated to be 2.66% (95% CI 2.57-2.75%) for men and 1.76% (95% CI 1.69-1.83%) for women [12]. Using European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) Registry data, the cumulative lifetime risk of ESKD up to age 90 years in Europe was estimated to be 1.40% or 0.73% for 40-year-old men or women, 1.32% or 0.68% for 50-year-old men or women, and 1.18% or 0.58% for 60-year-old men or women, respectively [13]. Using data from the United States Renal Data System (USRDS), the cumulative lifetime risk of ESKD from birth to age 100 + years in the total US population was estimated to be 3.96% (95% CI 3.93-3.99%) for men and 2.84% (95% CI 2.69-2.74%) for women [14].…”

Section: Discussionmentioning

confidence: 99%

“…ESKD end-stage kidney disease a "Eventually" corresponds to follow-up of more than 95 years had not initiated dialysis or had undergone pre-emptive kidney transplantation in Japan. However, the number of patients who had not initiated dialysis were not included in the studies from other countries [12][13][14]. Furthermore, the number of pre-emptive kidney transplant patients is small in Japan, with only 101 patients being reported in 2009 [6].…”

Section: Discussionmentioning

confidence: 99%

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Lifetime and age-conditional risk estimates of end-stage kidney disease requiring maintenance dialysis in Japan

Wakasugi

Narita

2020

Clin Exp Nephrol

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Background Lifetime risk is an epidemiologic measure that expresses the probability of disease in the remaining lifetime for an index age. It is also an easily understandable statistical measure used to communicate the absolute risk of disease to the lay population. The lifetime risk of end-stage kidney disease (ESKD) has never been reported for the Japanese population. Here, we used data from the Japanese Society of Dialysis Therapy (JSDT) to estimate the lifetime risk of ESKD by sex in Japan. Methods The lifetime risk of ESKD was estimated using life-table methods. We defined an incident case of ESKD as a patient with loss of kidney function that resulted in maintenance dialysis therapy. The number of incident cases of ESKD and number of ESKD deaths in 2017 were obtained from data published by the JSDT. The population and total number of deaths in Japan for the same year were obtained from National Vital Statistics. By including all-cause mortality, risks were adjusted for competing causes of death. Results The cumulative incidence of ESKD from birth until age 95 years was 3.14% [95% confidence interval (CI) 3.10-3.18] for men and 1.42% (1.39-1.44) for women. These probabilities illustrate that approximately 1 in 32 men and 1 in 71 women in Japan will develop ESKD that results in maintenance dialysis therapy in their lifetime. Conclusions Considerable sex differences were found in the lifetime risk of ESKD in Japan. This easily understandable information could be used to assist in public health education and planning.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Lifetime and age-conditional risk estimates of end-stage kidney disease requiring maintenance dialysis in Japan

Wakasugi

Narita

2020

Clin Exp Nephrol

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“…Per un paziente di 40 anni di sesso maschile negli USA, in Canada e in Europa, tale rischio si aggira intorno al 3,3%, al 2,7% e all'1,4%. In rapporto, nelle donne il rischio è inferiore e, rispettivamente, del 2,2%, dell'1,8% e dello 0,7% (20)(21)(22). La spiegazione potrebbe essere la maggiore progressione della MRC segnalata negli uomini, pur non escludendo l'ipotesi che le donne non abbiano le stesse opportunità di iniziare il trattamento dialitico, che hanno una maggiore propensione a optare per la terapia conservativa, fino all'ipotesi di una maggiore mortalità pre-ESRD.…”

Section: La Prevenzione Inizia Dall'identificazione E Dalla Cura Dei Fattori DI Rischio: Quali Sono Quelli Sesso-specifici Di Sviluppare unclassified

Salute renale per tutti e ovunque: riflessioni al femminile sul tema centrale della Giornata Mondiale del Rene 2020

Fantuzzi¹,

Berri

Tartaglione³

et al. 2020

G Clin Nefrol Dial

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The goal of the World Kidney Day 2020 (WKD) is “the promotion of public health by ensuring universal, equitable and sustainable access to care, making access to health for all people and social categories equitable”. Chronic Kidney Disease (CKD) is a complex and “demanding” health problem for patients and professionals, particularly in the more advanced stages of the disease. In addition to factors such as the so-called systemic conditions and risk factors, sex-related factors intervene in women, which can further complicate the CKD trend. For these reasons, one of the objectives of the World Kidney Day is that prevention and early treatment are included in the Universal Health Coverage (UHC) and that common strategies are implemented to promote awareness of this pathology. The woman has always played a central role in the “coordination” of family life and “taking care”, a role transversal to the different ethnic groups, as evidenced also by the data relating to living kidney donation. This article gives a reflection on some issues related to prevention and treatment of CKD from a female perspective, such as what strategies to identify to implement prevention in the family starting from nutrition, such as the advice for the preparation of a diet plan respectful of the traditions of the country of origin, the identification and treatment of risk factors in order to implement strategies aimed at prevention dedicated to the female world and which style distinguishes the female approach to care.

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“…Increased survival among the general population has been shown to coincide with lower mortality rates among dialysis patients ( 9 ). Even at constant incidence rates, the size of the RRT population may be expected to increase simply because dialysis patients are living longer ( 8 , 10 ). The latest findings indicate that there is a strong direct correlation between life expectancy and RRT prevalence at the country level ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

Is the Rise in the Prevalence of Renal Replacement Therapy at Older Ages the Price for Living Longer?

Peters

Westphal

Kramer

et al. 2018

Front. Public Health

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BackgroundRenal replacement therapy (RRT) is one of the most expensive in renal medicine. Cross-sectional studies suggest that life expectancy increases in the general population are associated with a higher burden of RRT. This study tests this hypothesis in a prospective setting among people aged 75+ living in Western Europe.MethodsWe gathered sex-specific data for 11 Western European countries in 2005–2014. RRT prevalence on country level was extracted from the ERA-EDTA registry, while data on population size and life expectancy for the 75+ age group came from the Eurostat database. GDP per capita was extracted from the OECD database. To measure the association between RRT prevalence and life expectancy, we performed Poisson regression models separately for each country and for all countries combined. To adjust for confounding, GDP per capita as well as time and country-fixed effects were included.ResultsOur analysis revealed that living longer coincides with rising RRT prevalence at ages 75+ in Western Europe between 2005 and 2014. On average, a 1-year increase in life expectancy was associated with a roughly 20% increase in RRT prevalence [(95% CI) 21–23% in men and 19–22% in women]. However, after adjustments for confounding were made, the association became insignificant among women and became weaker among men, falling to a level of 11% [(95% CI) 6–17%].ConclusionLiving longer was not necessarily associated with a higher burden of RRT in Western European countries.

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Lifetime risk of renal replacement therapy in Europe: a population-based study using data from the ERA-EDTA Registry

Cited by 13 publications

References 20 publications

Lifetime and age-conditional risk estimates of end-stage kidney disease requiring maintenance dialysis in Japan

Lifetime and age-conditional risk estimates of end-stage kidney disease requiring maintenance dialysis in Japan

Salute renale per tutti e ovunque: riflessioni al femminile sul tema centrale della Giornata Mondiale del Rene 2020

Is the Rise in the Prevalence of Renal Replacement Therapy at Older Ages the Price for Living Longer?

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