Lifetime reproductive output over two generations in patients with psychosis and their unaffected siblings: the Uppsala 1915–1929 Birth Cohort Multigenerational Study

MacCabe, James H.; Koupil, Ilona; Leon, David A.

doi:10.1017/s0033291709005431

Cited by 52 publications

(49 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This is consistent with other first-episode samples. [31][32][33][34] Mean household income (R2 560 ($365) per month) was less than half that of the general population (R5 360 ($777) per month), consistent with previous findings.…”

Section: Discussionsupporting

confidence: 90%

Social capital, pathway to care and duration of untreated psychosis: Findings from a low- and middle-income country context

Burns

Kirkbride

2012

S Afr J Psych

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 90%

Social capital, pathway to care and duration of untreated psychosis: Findings from a low- and middle-income country context

Burns

Kirkbride

2012

S Afr J Psych

View full text Add to dashboard Cite

“…While the mutation rate is low, the overall target size is large, involving many genes and regulatory regions. This model fits well with the apparent impact of rare structural and de novo variants on schizophrenia susceptibility [146,147,148,149,150,151,152], the reported effects of paternal age [153], and with the severe fertility disadvantages that have been observed in schizophrenia [154,155,156]. While structural variants do not appear to contribute significantly to risk for bipolar disorder, rare variants may play a role [157,158,159,160].…”

Section: Bipolar Disorder and Evolutionsupporting

confidence: 70%

“…Others have suggested that the observed association between schizotypal traits and creativity may partially explain the persistence of psychosis risk variants in the population [117,141,166,168,169,170,171]. Consistent with these notions, studies have shown at least moderate evidence for reduced fecundity in individuals with bipolar disorder and increased fecundity in their unaffected siblings, who presumably carry a reduced burden of risk variants and may express these traits in a milder, more advantageous form [142,155,156]. Antagonistic pleiotropy provides an attractive evolutionary model in this context, wherein alleles associated with an increased fitness for one trait also decrease fitness for another [143,144,172].…”

Section: Bipolar Disorder and Evolutionmentioning

confidence: 99%

Positive Traits in the Bipolar Spectrum: The Space between Madness and Genius

Greenwood¹

2016

Complex Psychiatry

View full text Add to dashboard Cite

Bipolar disorder is a severe, lifelong mood disorder for which little is currently understood of the genetic mechanisms underlying risk. By examining related dimensional phenotypes, we may further our understanding of the disorder. Creativity has a historical connection with the bipolar spectrum and is particularly enhanced among unaffected first-degree relatives and those with bipolar spectrum traits. This suggests that some aspects of the bipolar spectrum may confer advantages, while more severe expressions of symptoms negatively influence creative accomplishment. Creativity is a complex, multidimensional construct with both cognitive and affective components, many of which appear to reflect a shared genetic vulnerability with bipolar disorder. It is suggested that a subset of bipolar risk variants confer advantages as positive traits according to an inverted-U-shaped curve with clinically unaffected allele carriers benefitting from the positive traits and serving to maintain the risk alleles in the population. The association of risk genes with creativity in healthy individuals (e.g., NRG1), as well as an overall sharing of common genetic variation between bipolar patients and creative individuals, provides support for this model. Current findings are summarized from a multidisciplinary perspective to demonstrate the feasibility of research in this area to reveal the mechanisms underlying illness.

show abstract

“…On the one hand, it has been reported that sterilization rates were no higher in Uppsala than other parts of Sweden 36 . Moreover, it is worth noting that the majority of sterilisations performed on the grounds of "feeble-mindedness" in fact referred to socially marginal women with deviant sexual behaviour, such as unmarried working class girls seeking abortions (M Runcis, personal communication).…”

Section: Historical Context: Enforced Sterilisation In Twentieth Centmentioning

confidence: 96%

The effect of school performance upon marriage and long-term reproductive success in 10,000 Swedish males and females born 1915–1929

Goodman

Koupil

2010

Evolution and Human Behavior

View full text Add to dashboard Cite

Goodman, A; Koupil, I (2010) The effect of school performance upon marriage and long-term reproductive success in 10,000 Swedish males and females born 1915-1929. Evolution and human behavior , 31 (6 AbstractHumans are an exceptionally intelligent species, and the selective pressures which may have shaped these advanced cognitive powers are therefore of interest. This study investigates the fitness consequences of pre-reproductive school performance in a Swedish population-based cohort of 5244 males and 4863 females born [1915][1916][1917][1918][1919][1920][1921][1922][1923][1924][1925][1926][1927][1928][1929]. School performance was measured at around age 10 using three variables: mean schoolmarks; being promoted/held back in school; and recognised learning difficulties. Our primary outcomes were probability of ever marrying, total number of children and total number of grandchildren. In males (but not females), poorer school performance predicted fewer children and grandchildren. This was primarily mediated via probability of marriage; mortality and fertility within marriage were not important mediating pathways. The effect of school performance upon marriage in males was independent of early-life social and biological characteristics, including birthweight for gestational age, preterm birth, family composition and family socio-economic position. The effect of school performance upon the probability of marriage in males was, however, largely mediated by adult socioeconomic position. This suggests that in general sexual selection for cognitive abilities per se did not play a major role in either males or females in this cohort. Adult socio-economic position did not, however, fully explain the marriage disadvantage in males or (at marginal significance) females with particularly poor school performance. We conclude that school performance can affect long-term reproductive success. In this population, however, the effect is confined to males and is largely mediated by the increased probability of marriage which comes with their greater socio-economic success.

show abstract

Lifetime reproductive output over two generations in patients with psychosis and their unaffected siblings: the Uppsala 1915–1929 Birth Cohort Multigenerational Study

Abstract: Schizophrenia, but not affective psychosis, is associated with reduced biological fertility; this disadvantage is partly explained by marital status and persists into the second generation.

Cited by 52 publications

References 37 publications

Social capital, pathway to care and duration of untreated psychosis: Findings from a low- and middle-income country context

Social capital, pathway to care and duration of untreated psychosis: Findings from a low- and middle-income country context

Positive Traits in the Bipolar Spectrum: The Space between Madness and Genius

The effect of school performance upon marriage and long-term reproductive success in 10,000 Swedish males and females born 1915–1929

Contact Info

Product

Resources

About