Lifetime physical inactivity is associated with lung cancer risk and mortality

Cannioto, Rikki A.; Etter, John Lewis; LaMonte, Michael J.; Ray, Andrew D.; Joseph, Janine M.; Qassim, Emad Al; Eng, Kevin H.; Moysich, Kirsten B.

doi:10.1016/j.ctarc.2018.01.001

Cited by 21 publications

(18 citation statements)

References 43 publications

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“…Among never-smokers (OR = 3.00, 95% CI: 1.33–6.78) and former smokers (OR = 3.00, 95% CI: 1.33–6.78) the association was significant as well. The authors also described a significant positive correlation between lifetime physical inactivity and the mortality from lung cancer [Hazard ratio (HR) = 1.40, 95% CI: 1.14–1.71]; here the association remained significant also for the non-smoking patients [42]. A different study published in 2017 also evaluated the impact of physical activity on lung cancer risk.…”

Section: Physical Inactivitymentioning

confidence: 97%

“…Cannioto et al investigated the association of physical inactivity with lung cancer [42]. Since it has been proven for many types of malignant disease that lifetime inactivity goes along with an increased cancer risk, the authors wanted to show whether this holds true also for lung cancer, independently of other risk factors such as smoking.…”

Section: Physical Inactivitymentioning

confidence: 99%

“…Since it has been proven for many types of malignant disease that lifetime inactivity goes along with an increased cancer risk, the authors wanted to show whether this holds true also for lung cancer, independently of other risk factors such as smoking. In this hospital-based, case-control study, data from 660 lung cancer patients and 1335 matched controls, who did not suffer from any malignant disease, were analyzed [42]. Multivariate logistic regression analysis was used to assess the association between a primarily sedentary lifestyle and the risk of lung cancer.…”

Section: Physical Inactivitymentioning

confidence: 99%

See 2 more Smart Citations

Non-Smoking-Associated Lung Cancer: A distinct Entity in Terms of Tumor Biology, Patient Characteristics and Impact of Hereditary Cancer Predisposition

Smolle

Pichler

2019

Cancers

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Non-small cell lung cancer (NSCLC) in non-, and especially in never-smoking patients is considered a biologically unique type of lung cancer, since risk factors and tumorigenic conditions, other than tobacco smoke, come into play. In this review article, we comprehensively searched and summarized the current literature with the aim to outline what exactly triggers lung cancer in non-smokers. Changes in the tumor microenvironment, distinct driver genes and genetic pathway alterations that are specific for non-smoking patients, as well as lifestyle-related risk factors apart from tobacco smoke are critically discussed. The data we have reviewed highlights once again the importance of personalized cancer therapy, i.e., careful molecular and genetic assessment of the tumor to provide tailored treatment options with optimum chances of good response—especially for the subgroups of never-smokers.

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Section: Physical Inactivitymentioning

confidence: 97%

Section: Physical Inactivitymentioning

confidence: 99%

Section: Physical Inactivitymentioning

confidence: 99%

See 1 more Smart Citation

Non-Smoking-Associated Lung Cancer: A distinct Entity in Terms of Tumor Biology, Patient Characteristics and Impact of Hereditary Cancer Predisposition

Smolle

Pichler

2019

Cancers

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“…All these factors affect individuals’ physical and mental health. It has been shown that physical inactivity may play an important mediating role in some physical and psychological disorders [ 3 , 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Relationship between Walking and Emotional Health in China

Zhu

Chen

et al. 2020

IJERPH

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Walking has a positive impact on people’s emotional health. However, in the case of serious air pollution, it is controversial whether walking exercise can still improve individuals’ emotional health. Using data from the 2014 wave of the China Labor-Force Dynamics Survey, this study explored the relationship between walking and emotional health with different levels of environmental pollution. The results indicated that respondents who took regular walks had better emotional health than those who did not walk regularly. For those whose main mode of physical exercise was walking, the average number of walks per week was significantly and positively correlated with their emotional health; however, the average duration of the walk had no significant impact on their emotional health. Moreover, for those whose main mode of physical exercise was walking and who lived in neighborhoods with a polluted environment, regular walking still had a positive impact on their emotional health. This suggests that even if environmental pollution is serious, walking still plays an important role in regulating individuals’ mental health. We propose that in order to promote the emotional health of residents, it is necessary to create more public spaces for outdoor activities and simultaneously increase efforts to control environmental pollution.

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“…Lastly, in subgroup analyses by BMI classification we observed a statistically significant association between physical inactivity and increased mortality among overweight/obese patients that did not persist in normal weight patients. Because physical inactivity has been shown to associate with cancer endpoints independently of obesity, 32 these observations suggest that physical activity may confer an additional survival benefit in the overweight/obese population.…”

Section: Discussionmentioning

confidence: 99%

Physical inactivity and head and neck cancer mortality

et al. 2020

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Background This study was performed to examine the association between adulthood recreational physical inactivity (PIA) and mortality among patients with cancers of the head and neck. Methods Patients with head and neck cancer at Roswell Park between years 1990 to 1998 were included (N = 305). Multivariable Cox proportional hazard ratios (HR) with corresponding 95% confidence intervals (CI) were used to analyze the association between PIA and risk of dying. Results There was a 1.40‐fold increase in risk of dying among PIA patients, when compared to active patients with head and neck cancers (HR = 1.40, CI: 1.03‐1.91). This was observed greater in PIA women (HR = 2.40, CI: 1.28‐4.52), patients who were overweight/obese (HR = 1.76, CI: 1.09‐2.85), patients with pharynx as the primary site (HR = 1.85, CI: 1.01‐3.38), and patients with distant metastasis (HR = 5.19, CI: 1.37‐19.65). Conclusion Physically inactive patients with head and neck cancers are at significantly greater risk of dying when compared to patients who are active.

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Lifetime physical inactivity is associated with lung cancer risk and mortality

Abstract: These data add to the body of evidence suggesting that physical inactivity is an independent risk and prognostic factor for cancer. Additional research utilizing prospectively collected data is needed to substantiate the current findings.

Cited by 21 publications

References 43 publications

Non-Smoking-Associated Lung Cancer: A distinct Entity in Terms of Tumor Biology, Patient Characteristics and Impact of Hereditary Cancer Predisposition

Non-Smoking-Associated Lung Cancer: A distinct Entity in Terms of Tumor Biology, Patient Characteristics and Impact of Hereditary Cancer Predisposition

Exploring the Relationship between Walking and Emotional Health in China

Physical inactivity and head and neck cancer mortality

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