Lifetime depressive and somatic symptoms as preclinical markers of late-onset depression

Hein, Sandra; Bonsignore, Marzia; Barkow, Katrin; Jessen, Frank; Ptok, Ursula; Heun, Reinhard

doi:10.1007/s00406-003-0399-4

Cited by 36 publications

(22 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most data suggest chronic pain predisposes patients to the emergence of depression [3••, Class I]. For example, among elderly patients, the presence of joint pain was one of the most significant predictors of incident depression at 5-year follow-up [8,Class II]. Conversely, depression can predict future pain.…”

Section: Opinion Statementmentioning

confidence: 98%

Chronic pain and comorbid depression

Leo

2005

Curr Treat Options Neurol

View full text Add to dashboard Cite

For patients with chronic pain, the experience of pain is intimately linked with psychologic distress. Epidemiologic studies indicate that depression is a common comorbidity accompanying chronic pain states. Longitudinal studies also suggest that depression can predict the emergence of chronic pain in selected populations. Emerging evidence suggests numerous pathophysiologic mechanisms that underlie the coexistence of depression and chronic pain states. Comorbid depression can complicate the presentation, clinical course, and response to treatment of patients with chronic pain. The literature reviewed herein focuses on treatment approaches applicable to chronic, nonmalignant pain states predominantly. Although antidepressants offer advantages in simultaneously producing pain relief and mitigating depression, not all antidepressants share equal efficacy; those with noradrenergic and serotonergic influences seem to fare better than agents with single neurotransmitter influences. Treatment of depression may be essential to fully enlist the patient with chronic pain in comprehensive pain management and rehabilitative approaches. Management plans of patients with chronic pain can be designed with specific individual patient needs in mind, and may involve concurrent use of antidepressants, analgesics, and psychotherapeutic approaches.

show abstract

Section: Opinion Statementmentioning

confidence: 98%

Chronic pain and comorbid depression

Leo

2005

Curr Treat Options Neurol

View full text Add to dashboard Cite

show abstract

“…Data are in favor of adding the existence of physical symptoms to the current criteria rather than to oppose them to psychologic symptoms. The presence of somatic symptoms of depression actually predicts the onset of a further episode of depression [23].…”

Section: "Diagnosis Is Hidden Because Of a Physical Presentation Of Smentioning

confidence: 99%

False beliefs: The current treatment of patients with depression

Lecrubier

2003

Curr Psychiatry Rep

View full text Add to dashboard Cite

“…However, this may be explained by the possibility that depression in a community sample is less likely to be complicated by factors such as comorbid vascular disease. Hein et al (2003), in a 2-year prospective follow-up study, identified lifetime depressive and somatic symptoms as preclinical markers of late-onset depression. Certain symptoms, when present for over 2 weeks at any age, individually predicted lateonset depression.…”

Section: Vascular Diseasementioning

confidence: 99%

Late-onset depression: issues affecting clinical care

Variend¹,

Gopal²

2008

Adv. psychiatr. treat

View full text Add to dashboard Cite

A growing body of evidence suggests that late-onset depression (depression occurring for the first time in later life) differs from early-onset (recurrent) depression in terms of clinical features, aetiology, neuroanatomical substrates and prognosis. Some evidence suggests that late-onset depression is more associated with somatic symptoms, cognitive deficits, cerebral structural abnormalities, vascular disease ('vascular depression') and poorer treatment outcomes than is early-onset depression. Both general adult and old age psychiatrists face the challenges of managing late-onset depression. In this article we attempt to clarify specific issues relating to late-onset depression in terms of clinical features, aetiology, treatment response and prognosis.Hannele Variend is an academic specialist registrar in general adult psychiatry working in the Yorkshire Deanery. Y. Vishnu Gopal is a consultant psychiatrist at the Hartington Unit (Royal Hospital, Chesterfield S44 5BL, UK. Email: vgopal@doctors.org.uk). His interests include assessment and management of cognitive dysfunctions.

show abstract

Lifetime depressive and somatic symptoms as preclinical markers of late-onset depression

Abstract: Different symptoms can be used individually and in combination to predict later depression. This might allow early treatment.

Cited by 36 publications

References 45 publications

Chronic pain and comorbid depression

Chronic pain and comorbid depression

False beliefs: The current treatment of patients with depression

Late-onset depression: issues affecting clinical care

Contact Info

Product

Resources

About