Lifetime Characteristics of Evening-Preference and Irregular Bed-Rise Time Are Associated With Lifetime Seasonal Variation of Mood and Behavior: Comparison Between Individuals With Bipolar Disorder and Healthy Controls

Abstract

Sleep-wake cycle disruption and seasonal variation in mood and behavior have been associated with mood disorders. This study aimed to investigate the lifetime characteristics of the sleep-wake cycle and its association with the lifetime characteristics of seasonality in individuals with bipolar disorder. Circadian preference, regularity of bed-rise time, and seasonality were evaluated on a lifetime basis using the Composite Scale of Morningness, the Sleep Timing Questionnaire, and the Seasonal Pattern Assessment Questionnaire in clinically stable individuals with bipolar I/II disorders (n = 103/97) and healthy controls (n = 270). Bipolar groups were more likely to have evening preference and irregular bed-rise time. These characteristics were interrelated and, particularly, more prevalent in bipolar II disorder. Seasonality, which was also more prevalent in the bipolar groups, was associated with evening preference and irregularity of the weekday bed-rise time.

Long-term response to mood stabilizer treatment and its clinical correlates in patients with bipolar disorders: a retrospective observational study

“…1). Among those patients, there were 60 participants who were involved in other clinical and genetic studies described elsewhere (Baek et al 2011, 2016; Yang et al 2015). This study was approved by the Institutional Review Board of the Samsung Medical Center.

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“…The evaluation was performed through a direct interview using the revised version of the Korean version of the Diagnostic Interview for Genetic Studies (Joo et al 2004), and is described in detail elsewhere (Baek et al 2011, 2016; Yang et al 2015). The rated variables cover age at onset and course of mood episodes, manifested symptoms, and comorbid psychiatric conditions on a lifetime basis.…”

The bipolarity of light and dark: A review on Bipolar Disorder and circadian cycles

“…These patients had a greater percentage of evening chronotype (with a later timing of sleep) than the control group (Ahn, Chang et al 2008). More recently, it was additionally detected an association of the evening chronotype in BD with a longer sleep latency ) and irregular bed-rise time (Baek, Kim et al 2014). Furthermore, bipolar patients exhibit not only abnormalities in phase preference but also in amplitude, which usually is lower (Boudebesse, Lajnef et al 2013).…”

Investigating the mechanism(s) underlying switching between states in bipolar disorder

“…In fact, this sub-population may exhibit with a more severe form of the disorder seen in males and females, although rapid cycling is more likely seen in females (Geoffroy et al, 2013). Such seasonality may be associated with BD type II patients, particularly in subjects that evidence with late evening preference and irregular bed-rise times (Baek et al, 2014). It was recommended that future studies aimed at understanding seasonal variation in BD require stringent research criterion (Murray et al, 2013).…”