Lifetime and current depression in the German National Cohort (NAKO)

Streit, Fabian; Zillich, Lea; Frank, Josef; Kleineidam, Luca; Wagner, Michael; Baune, Bernhard T.; Klinger-König, Johanna; Grabe, Hans J.; Pabst, Alexander; Riedel‐Heller, Steffi G.; Schmiedek, Florian; Schmidt, Börge; Erhardt, Angelika; Deckert, Jürgen; Rietschel, Marcella; Berger, Klaus

doi:10.1080/15622975.2021.2014152

Cited by 27 publications

(19 citation statements)

References 63 publications

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“…Clinically relevant depressive symptoms were detected by the CES-D in 4.58% of the study sample. This in line with previous epidemiological data in similar populations ( 47 ).…”

Section: Resultssupporting

confidence: 93%

Association Between Self-rating Depression Scores and Total Ghrelin and Adipokine Serum Levels in a Large Population-Based Sample

et al. 2022

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BackgroundGhrelin and the adipokines leptin and adiponectin have been suggested to be involved in mood and anxiety regulation and to be altered in affective disorders. However, studies investigating the association between ghrelin, leptin and adiponectin and depressive symptomatology are scarce but might contribute to a better understanding of their involvement in mood regulation. We thus aimed investigating the association between depressive symptomatology and total ghrelin as well as leptin and adiponectin serum levels in a large population-based sample.MethodsTotal serum ghrelin, adiponectin and leptin levels were determined in 1666 subjects of a population-based cross-sectional study (“LIFE”). The Center for Epidemiological Studies Depression Scale (CES-D) and the Inventory of Depressive Symptoms – Self Rating (IDS-SR) were administered. Multiple linear regression analyses were conducted to examine the association between total serum ghrelin, leptin and adiponectin and the intensity of depressive symptoms.ResultsIn the total sample (n = 1,092), neither ghrelin nor leptin or adiponectin serum levels showed a significant association with CES-D or IDS-SR sum scores (N = 1,092) or in depressed/non-depressed subjects. Leptin serum levels showed a significantly positive association with IDS-SR sum scores in elderly men (≥60 years; β = 0.122, 95% CI: 0.009; 0.236; p = 0.035).ConclusionOur study suggests that peripheral levels of ghrelin and adipokines in a cross-sectional study design might not be sufficient to measure their involvement in depression, suggesting that associations are more complex and multi-layered.

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“…Clinically relevant depressive symptoms were detected by the CES-D in 4.58% of the study sample. This in line with previous epidemiological data in similar populations ( 47 ).…”

Section: Resultssupporting

confidence: 93%

Association Between Self-rating Depression Scores and Total Ghrelin and Adipokine Serum Levels in a Large Population-Based Sample

et al. 2022

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“…As shown in the Greek [ 29 ], German [ 30 ], Peruvian [ 31 ], United States [ 32 ], or Russia [ 33 ] populations, and in our study, women suffered from depression more often than men. This result was confirmed in a study covering 24 European countries, with the most significant differences observed in Southern Europe, the former Soviet Union and Poland [ 34 ].…”

Section: Discussionsupporting

confidence: 80%

The Prevalence of Depression Symptoms and Their Socioeconomic and Health Predictors in a Local Community with a High Deprivation: A Cross-Sectional Studies

Polak

Nowicki

Naylor

et al. 2022

IJERPH

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Depression is a heterogeneous and etiologically complex psychiatric syndrome thatshows a strong sexual dimorphism and often impacts people with a low socioeconomic status (SES). The aim of the study was to estimate the occurrence of depression symptoms in a local community with a high deprivation rate, the example being the inhabitants of the JanówLubelski County in eastern Poland. A cross-sectional study was carried out on 3752 people aged between 35 and 64. The prevalence of depression symptoms was assessed using the Patient Health Questionnaire-9 (PHQ-9) scale. In the screening for depression symptoms in the entire population we studied, the risk of depression symptoms was 16.1% (n = 605), with women having a significantly higher mean score than men (p < 0.001). Significant predictors associated with the achievement of 10 points and more in the PHQ-9 assessment in the case of women and men were: living alone, education and having comorbidities. Moreover, female participants living in rural areas were significantly more likely to exhibit depression symptoms, whereas smoking was a significant predictor of depressive symptoms in men. It was observed that in the case of obese women, the chance of being in the higher category of the PHQ-9 assessment was 1.41 times higher than in women with normal body weight. However, in the case of men, an increase in age by one year increased the chance of being in a higher category by 1.02 times. Moreover, the odds of falling into a higher category, as assessed by the PHQ-9 questionnaire, among men who drink alcohol more than once a week was 1.7 times higher than in men who do not drink or consume alcohol occasionally. Summarising the results of studies conducted in a local community characterised by a high deprivation rate, socioeconomic and health variables related to SES significantly impacted the incidence of depression, but they differ in terms of gender.

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“…This study is encouraging in reporting that quality of life measures by SF-12 were similar to population averages, and the prevalence of depression was only slightly higher than in the general young adult population in Germany (10.8% versus 8%). 1,11 This is different from other single-center studies finding that pediatric liver transplant recipients age 18-25 y had significantly impaired scores. 12 The use of different survey forms may be responsible for the difference, but when developing strategies to improve long-term outcomes, it is worth considering other contributing factors that come with a different transplant center (eg, patient selection, center resources devoted to social support, and mental health) in a different country (eg, healthcare systems and cultural norms).…”

contrasting

confidence: 69%

Moving the Goalpost: From “Alive” to “Ideal”

Yeh

2023

Transplantation

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Lifetime and current depression in the German National Cohort (NAKO)

Cited by 27 publications

References 63 publications

Association Between Self-rating Depression Scores and Total Ghrelin and Adipokine Serum Levels in a Large Population-Based Sample

Association Between Self-rating Depression Scores and Total Ghrelin and Adipokine Serum Levels in a Large Population-Based Sample

The Prevalence of Depression Symptoms and Their Socioeconomic and Health Predictors in a Local Community with a High Deprivation: A Cross-Sectional Studies

Moving the Goalpost: From “Alive” to “Ideal”

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