Lifestyle strategies to promote proteostasis and reduce the risk of Alzheimer’s disease and other proteinopathies

Almeida, Michael F.; Farizatto, Karen L.G.; Almeida, Renato S.; Bahr, Ben A.

doi:10.1016/j.arr.2023.102162

Cited by 2 publications

(1 citation statement)

References 156 publications

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“…The program of lifestyle interventions was associated with a statistically significant 3.23-year decrease in Receiver operating characteristic curve of classifiers using rest tremor data (left) and postural tremor data (right). In the neurology field, various lifestyle interventions have been assessed for their ability to prevent or slow the progression of dementia, and to reduce the risk of developing Alzheimer's disease and other conditions, including PD, that have protein accumulation pathology (149,150). A systematic literature review that evaluated studies of multidomain lifestyle interventions (diet, physical activity and cognitive training) on cognitive outcomes in older adults, including those at risk of dementia found that these strategies had beneficial effects in preventing or delaying cognitive decline (151).…”

Section: Discussionmentioning

confidence: 99%

The rise of Parkinson’s disease is a global challenge, but efforts to tackle this must begin at a national level: a protocol for national digital screening and “eat, move, sleep” lifestyle interventions to prevent or slow the rise of non-communicable diseases in Thailand

Bhidayasiri,

Sringean,

Phumphid

et al. 2024

Front. Neurol.

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The rising prevalence of Parkinson’s disease (PD) globally presents a significant public health challenge for national healthcare systems, particularly in low-to-middle income countries, such as Thailand, which may have insufficient resources to meet these escalating healthcare needs. There are also many undiagnosed cases of early-stage PD, a period when therapeutic interventions would have the most value and least cost. The traditional “passive” approach, whereby clinicians wait for patients with symptomatic PD to seek treatment, is inadequate. Proactive, early identification of PD will allow timely therapeutic interventions, and digital health technologies can be scaled up in the identification and early diagnosis of cases. The Parkinson’s disease risk survey (TCTR20231025005) aims to evaluate a digital population screening platform to identify undiagnosed PD cases in the Thai population. Recognizing the long prodromal phase of PD, the target demographic for screening is people aged ≥ 40 years, approximately 20 years before the usual emergence of motor symptoms. Thailand has a highly rated healthcare system with an established universal healthcare program for citizens, making it ideal for deploying a national screening program using digital technology. Designed by a multidisciplinary group of PD experts, the digital platform comprises a 20-item questionnaire about PD symptoms along with objective tests of eight digital markers: voice vowel, voice sentences, resting and postural tremor, alternate finger tapping, a “pinch-to-size” test, gait and balance, with performance recorded using a mobile application and smartphone’s sensors. Machine learning tools use the collected data to identify subjects at risk of developing, or with early signs of, PD. This article describes the selection and validation of questionnaire items and digital markers, with results showing the chosen parameters and data analysis methods to be robust, reliable, and reproducible. This digital platform could serve as a model for similar screening strategies for other non-communicable diseases in Thailand.

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Section: Discussionmentioning

confidence: 99%