Lifestyle-related weight gain in obese men with newly diagnosed obstructive sleep apnea

Traviss, Karol; Bare, Susan I.; Fleming, J. E. E.; Ryan, Clodagh

doi:10.1016/s0002-8223(02)90160-4

Cited by 19 publications

(19 citation statements)

References 24 publications

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“…However, recent studies lead to the opposite conclusion since a high propensity of the apneic individuals toward weight gain was found in the year preceding the OSAS diagnosis 9,10 or since symptom onset. 11 This apparent paradox requires a more detailed characterization of the energy expenditure profile of apneic patients.…”

Section: Discussionmentioning

confidence: 99%

“…Traviss et al 11 also found important reported weight gain in 84% of their apneic subjects following the onset of symptoms. This is consistent with the observation that a treatment based on continuous positive airway pressure (CPAP) for 6 months decreased body weight in some subjects, and visceral fat deposition even in subjects who did not lose weight.…”

Section: Introductionmentioning

confidence: 87%

“…Accordingly, some studies found a greater propensity of apneic individuals toward weight gain. [9][10][11] Phillips et al 9,10 showed that patients had gained 5.2-7.4 kg during the year preceding the OSAS diagnosis compared to control subjects who had displayed a small weight variation (À0.5 to 0.5 kg).…”

Section: Introductionmentioning

confidence: 99%

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Relationship between severity of nocturnal desaturation and adaptive thermogenesis: preliminary data of apneic patients tested in a whole-body indirect calorimetry chamber

et al. 2005

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The purpose of this study was to investigate the possibility of a relationship between the severity of obstructive sleep apnea syndrome (OSAS) and adaptive thermogenesis. Daily energy expenditure (DEE) and sleeping metabolic rate (SMR) were measured in apneic and a priori nonapneic subjects who were tested in a whole-body indirect calorimetry chamber for 24 h. The apneic patients were diagnosed by nocturnal home oximetry to determine the percentage of total recording time spent below 90% arterial oxygen saturation (% TRT o90% SaO 2 ). Reference equations established from body weight and age in nonapneic subjects were used to predict DEE and SMR in apneic patients. The predicted values of the apneic patients were then compared to their measured values. No significant difference was found between predicted and measured values in SMR nor in DEE. We observed a significant relationship between the severity of nocturnal desaturation and the difference between predicted and measured DEE in apneic patients (r ¼ À0.74, Po0.05) and a similar negative trend with SMR (r ¼ À0.65, P ¼ 0.08). These preliminary data suggest that a nocturnal hypoxia may influence adaptive thermogenesis in apneic patients and complicate their body weight regulation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 87%

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Relationship between severity of nocturnal desaturation and adaptive thermogenesis: preliminary data of apneic patients tested in a whole-body indirect calorimetry chamber

et al. 2005

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“…3 In one review, it has been estimated that 58% of OSA can be attributable to excess weight. 4 There also is evidence that OSA itself contributes to weight gain, [5][6][7] thus creating an adverse positive feedback loop whereby increasing weight leads to OSA, and OSA results in further weight gain. Treatment of OSA with continuous positive airway pressure (CPAP) should therefore prevent further weight gain or facilitate weight loss.…”

Section: S C I E N T I F I C I N V E S T I G a T I O N Smentioning

confidence: 99%

Impact of Treatment with Continuous Positive Airway Pressure (CPAP) on Weight in Obstructive Sleep Apnea

Quan

Budhiraja

Clarke

et al. 2013

Journal of Clinical Sleep Medicine

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“…84 The relationship between OSAS and propensity to weight gain and obesity 85,86 seems therefore paradoxical based on the fact that this disease is also characterized by several energy consuming factors such as sleep deprivation, sleep fragmentation, increase in breathing effort and motor activity, [87][88][89] as well as with activation of sympathetic activity 90,91 and increased EE. 92,93 In order to better investigate this issue, eight obese individuals with positive diagnosis for OSAS (determined by continuous nocturnal home oxymetry) were tested in the whole-body indirect calorimetric chamber in Laval University.…”

Section: Organochlorines: Obesogen Pollutants?mentioning

confidence: 99%

Clinical significance of adaptive thermogenesis

et al. 2007

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The epidemic of obesity is developing faster than the scientific understanding of an efficient way to overcome it, as reflected by the low success rate of short-and long-term weight loss interventions. From a clinical standpoint, this suggests that the body tends to defend a set point of possible genetic origin in the context of a weight-reducing program. As described in this paper, this limited therapeutic success may depend on adaptive thermogenesis, which represents in this case the decrease in energy expenditure (EE) beyond what could be predicted from the changes in fat mass or fat-free mass under conditions of standardized physical activity in response to a decrease in energy intake. This issue has been documented in recent studies that have shown in obese individuals adhering to a weight reduction program a greater than predicted decrease in EE, which in some cases was quantitatively sufficient to overcome the prescribed energy restriction, suggesting a role for adaptive thermogenesis in unsuccessful weight loss interventions and reduced body weight maintenance. As also discussed in this paper, this 'adaptive thermogenesis' can be influenced by environmental factors, which have not been frequently considered up to now. This is potentially the case for plasma organochlorine concentration and oxygen desaturation in obstructive sleep apnea syndrome. It is concluded that health professionals should be aware that in some vulnerable individuals, adaptive thermogenesis can be multicausal, and has the capacity to compensate, at least partly, for the prescribed energy deficit, possibly going beyond any good compliance of some patients.

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Lifestyle-related weight gain in obese men with newly diagnosed obstructive sleep apnea

Cited by 19 publications

References 24 publications

Relationship between severity of nocturnal desaturation and adaptive thermogenesis: preliminary data of apneic patients tested in a whole-body indirect calorimetry chamber

Relationship between severity of nocturnal desaturation and adaptive thermogenesis: preliminary data of apneic patients tested in a whole-body indirect calorimetry chamber

Impact of Treatment with Continuous Positive Airway Pressure (CPAP) on Weight in Obstructive Sleep Apnea

Clinical significance of adaptive thermogenesis

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