Lifestyle Intervention With or Without Lay Volunteers to Prevent Type 2 Diabetes in People With Impaired Fasting Glucose and/or Nondiabetic Hyperglycemia

Sampson, Michael J.; Clark, Allan; Bachmann, Max; Garner, Nikki; Irvine, Lisa; Howe, Amanda; Greaves, Colin; Auckland, Sara; Smith, Jane; Turner, Jeremy; Rea, Dave; Rayman, Gerry; Dhatariya, Ketan; John, W. Garry; Barton, Garry; Usher, Rebecca; Ferns, Clare; Pascale, Melanie

doi:10.1001/jamainternmed.2020.5938

Cited by 37 publications

(55 citation statements)

References 70 publications

(347 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…27,28 People with normal weight can bene t more from exercise or gain the same bene ts as obese people, and prediabetes. 29 In our study, daily exercise can reduce the risk of diabetes by 19% for overweight older adults, but the risk of diabetes did not show a signi cant decline for people with normal weight who exercised daily. This may be because people with normal body weight already had a low risk of diabetes.…”

Section: Discussioncontrasting

confidence: 49%

Fluctuations in Waist Circumference Increase the Risk of Diabetes in 61,587 Older Adults: 4 Years’ Chort Study

Liu

Cui

et al. 2021

Preprint

View full text Add to dashboard Cite

Purpose:To evaluate the effect of fluctuations in waist circumference (WC), weight, body mass index (BMI) on diabetes incidence in older adults.Patients and methods:We examined a prospective cohort of 61,587 older adults (age, 60-96 years) who did not have diabetes at study initiation. Data on weight, BMI, and WC were collected and participants were followed-up until 31 December 2019 . The main endpoint was new-onset diabetes. A Cox regression model was used to estimate the risk of diabetes (hazard ratios [HRs] and confidence intervals [CI]) in these participants.Results:During a mean followed-up of 3.6 years, individuals being overweight (HR [95% CI] 1.87 [1.62-2.17]), obesity (1.41 [1.26-1.59]), abdominal obesity (1.42 [1.28-1.58]), and obesity plus abdominal obesity at baseline (1.93 [1.66-2.25]) had higher risk of diabetes onset. Compared with older adults who “remained normal WC”, who “remained abdominally obese” (HR=1.66), “became abdominally obese”(HR=1.58) and “achieved normal WC” (HR=1.36) were also significantly associated with diabetes onset,as well as increase in WC >3 cm or >5% compared with baseline level . Weight gain or loss >6 kg or weight gain >5%; increase or decrease in BMI >2 kg/m2 or an increase in BMI >10% were associated with a higher diabetes risk. Diabetes risk reduced by 19% in overweight older adults who exercised daily.Conclusion:For old adults, waist circumference, BMI and healthy weight maintenance reduce diabetes risk. The findings may provide evidence for developing guidelines of proper weight and waist circumference control for older adults.

show abstract

Section: Discussioncontrasting

confidence: 49%

Fluctuations in Waist Circumference Increase the Risk of Diabetes in 61,587 Older Adults: 4 Years’ Chort Study

Liu

Cui

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…There is limited evidence relating to the benefits of different organisational types and locations 31 . Peer‐based interventions may not provide additional benefit to the general population 32 ; however, they may be useful when targeting minority groups.…”

Section: Discussionmentioning

confidence: 99%

A simulation study of the economic and health impact of a diabetes prevention programme in Ireland

et al. 2021

View full text Add to dashboard Cite

Aims Type 2 diabetes is a major public health issue that has a large effect on society including its health and social services. The aims of this paper are to generate a projection of the number of cases and explore the potential impact of a preventive intervention targeted at people with pre‐diabetes on disease prevalence, complications, mortality and cost. Methods A Markov simulation model of diabetes and pre‐diabetes in Ireland, for the period 1991 to 2036, was generated based on international epidemiological data. The simulation was calibrated with the available Irish data on the prevalence of pre‐diabetes, diabetes and diabetic complications. The economic and health impact of a hypothetical nationwide preventive intervention programme, which reduces the incidence by a factor consistent with the international literature, was estimated under three scenarios of alternative effectiveness and uptake. Results The estimated number of people over 40 years of age with type 2 diabetes in Ireland is projected to increase from 216,000 in 2020 to 414,000 in 2036. A prevention programme, based on the NHS Diabetes Prevention Programme, is estimated to result in a reduction of between 2000 (0.5%) and 19,000 (4.6%) in the number of prevalent cases of diabetes in 2036 resulting in substantial health and quality of life benefits. Conclusions A wide range of initiatives with uncertain outcomes will be required to reduce the impact of obesity and type 2 diabetes. A diabetes prevention programme seems likely to be worth pursuing as one element of this set of initiatives.

show abstract

“…Results from the Norfolk Diabetes Prevention Study (NDPS) 5 have recently been published. This is one of the largest diabetes prevention research studies in the last 30 years, involving over 1000 people over an 8‐year period.…”

Section: Preventing Type 2 Diabetesmentioning

confidence: 99%

Update on technologies, medicines and treatments

O’Neill

2021

Diabet Med

View full text Add to dashboard Cite

Lifestyle Intervention With or Without Lay Volunteers to Prevent Type 2 Diabetes in People With Impaired Fasting Glucose and/or Nondiabetic Hyperglycemia

Cited by 37 publications

References 70 publications

Fluctuations in Waist Circumference Increase the Risk of Diabetes in 61,587 Older Adults: 4 Years’ Chort Study

Fluctuations in Waist Circumference Increase the Risk of Diabetes in 61,587 Older Adults: 4 Years’ Chort Study

A simulation study of the economic and health impact of a diabetes prevention programme in Ireland

Update on technologies, medicines and treatments

Contact Info

Product

Resources

About