Lifestyle intervention up-regulates gene and protein levels of molecules involved in insulin signaling in the endometrium of overweight/obese women with polycystic ovary syndrome

Abstract

This study was supported financially by the Swedish Research Council (A.L.H., 20324), Karolinska Institutet and the Stockholm County Council. None of the authors has any conflict of interest to declare.

Physiological Aspects of Female Fertility: Role of the Environment, Modern Lifestyle, and Genetics

“…A compounding factor for many women with PCOS is obesity which has a synergistic effect to reduce the chance of conception (29), leading to a greater perturbation in endometrial gene expression (29), as demonstrated by the association of an increase in BMI being associated with a reduced chance of conception using the oocyte donor model (81) [for a review, see Schulte et al (302)]. However, lifestyle interventions with diet and exercise will lead to alterations in endometrial gene expression (348), although it is not clear whether the improved conception rates noted due to lifestyle interventions are due to an endometrial effect, an oocyte effect, or a combination of both.…”

Significado cardiometabólico do excesso de peso/obesidade numa população de 263 mulheres inférteis com síndrome do ovário poliquístico

“…Apesar da insulino-resistência e dos distúrbios metabólicos poderem estar associados ao SOP independentemente da obesidade, a verdade é que mulheres obesas com SOP exibem maior insulino-resistência e prevalência/gravidade de desequilíbrios metabólicos, o que imputa ao peso/massa corporal um papel relevante na condição de SOP. Por outro lado, intervenções no estilo de vida que favoreçam a perda de peso têm-se demonstrado determinantes na melhoria global das co-morbilidades associadas ao SOP, e por conseguinte, devem ser promovidas sobretudo junto das mulheres obesas com SOP 37,38 .…”

Nutritional support and dietary interventions for women with polycystic ovary syndrome

“…73 Results from a study investigating the effects of a 3-month LSM in overweight/obese women with PCOS with anovulation, hyperandrogenism and polycystic ovaries compared to BMI-matched regularly menstruating controls, normal weight PCOS and normal weight controls showed that women with PCOS exhibited lower levels of insulin receptor substrate-1 and glucose transporter-4 (GLUT4) mRNA in their proliferative endometrium compared to BMI-matched controls, whereas LSM led to decreased body weight, improved menstrual regularity and increased endometrial insulin sensitivity. 61 In conclusion, LSM (diet plus regular physical activity) should be the first-line strategy for the management of PCOS. The main challenge remains the long-term maintenance of healthy dietary attitudes and insulin sensitivity.…”

“…15,16,48,49,58,[60][61][62][63][64] Results from a cross-sectional study showed that women with PCOS were more likely to follow a number of both healthy body weight management practices (balanced diet, reduced fat or sugar intake, adoption of a low-GI diet) as well as paradoxical nonhealthy attitudes (ie, increased smoking, use of laxative and diet pills) compared to women without PCOS. 65 Although most clinicians are in favor of lifestyle changes for the management of PCOS, the majority of women with PCOS reported that they rarely receive lifestyle advice from their therapists.…”