Lifestyle habits to prevent the development of benign prostatic hyperplasia: Analysis of Japanese nationwide datasets

Nagakura, Yukinori; Hayashi, Maya; Kajioka, Shunichi

doi:10.1016/j.prnil.2022.06.004

Cited by 5 publications

(3 citation statements)

References 43 publications

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“…This result is in accordance with a recent study that demonstrates association between development of nonalcoholic fatty liver disease, a metabolic aberration-associated disease, and prostate volume. 32,33 In this study, there was no significant difference between the CRP in the groups. The outcome is identical to the previous one, when men with elevated CRP levels were not more likely to experience rapid in creases in prostate volume, obstructive LUTS, or PSA level.…”

mentioning

confidence: 48%

Association Between Neutrophil-to-Lymphocyte Ratio and Benign Prostatic Hyperplasia: Results from the TCLSIH Cohort Study

Song,

Gu,

Guo

et al. 2023

JIR

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Purpose The prevalence of benign prostatic hyperplasia (BPH) in the general Chinese adult male population has risen sharply over the past few decades. Increasing evidence suggests that inflammation plays an important role in the pathogenesis of BPH. To better understand the role of inflammation in the pathogenesis of BPH, we can use the neutrophil-to-lymphocyte ratio (NLR) because it is a simple and effective marker of inflammation and immunity. This study aims to prospectively investigate the association between NLR levels and the prevalence of BPH in a general Chinese adult male population. Patients and Methods This study included a total of 15,783 male participants free from BPH at baseline. NLR was measured according to the complete blood count. BPH was defined as total prostate volume (TPV) ≥30 mL, and TPV was determined by transabdominal ultrasonography. Multivariable Cox proportional hazards models were fitted to calculate hazards ratios (HRs) and corresponding 95% confidence intervals (CIs) for BPH risk with NLR levels. Results During a median follow-up of 2.7 years, 5078 BPH cases were documented. After adjusting for age, body mass index, smoking, alcohol, education, occupation, income, physical activity, total energy intake, personal and family history of disease, and inflammation markers, the multivariable-adjusted HRs of BPH were 1.00 (reference), 1.08 (95% CIs 0.99, 1.17), 1.10 (95% CIs1.02, 1.19), and 1.12 (95% CIs1.03, 1.21), respectively, for participants with NLR in the first, second, third, and fourth quartiles ( P for trend <0.01). Conclusion Higher NLR levels were associated with a higher risk of BPH in Chinese adult male population. Our findings support the notion that NLR levels may be an important target for BPH prevention and intervention.

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confidence: 48%

Association Between Neutrophil-to-Lymphocyte Ratio and Benign Prostatic Hyperplasia: Results from the TCLSIH Cohort Study

Song,

Gu,

Guo

et al. 2023

JIR

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“…Data on gender, age, BMI, and presence or absence of hypertension, diabetes, dyslipidemia, musculoskeletal disorders, and support/care-need certification were obtained from the National Health Insurance Database of Japan (NDB) [ 22 , 23 ].…”

Section: Methodsmentioning

confidence: 99%

Predictive Factors Associated with Future Decline in Swallowing Function among Japanese Older People Aged ≥ 75 Years

Iwai,

Azuma,

Yonenaga

et al. 2024

IJERPH

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Predictive factors associated with a decline in swallowing function after 2 years were examined in 3409 Japanese older people aged ≥ 75 years who had undergone a dental checkup in Gifu Prefecture, Japan. Participants with normal swallowing function in a baseline survey in April 2018 were followed for 2 years. Swallowing function was assessed using a repetitive saliva swallowing test. In our study, 429 participants (13%) who were swallowing less than three times in 30 s based on a repetitive saliva swallowing test after 2 years were diagnosed as those with decline in swallowing function. Multivariate logistic regression analyses showed the decline in swallowing function after 2 years was associated with the male gender (odds ratio [ORs]: 0.772; 95% confidence interval [CIs]: 0.615–0.969), age ≥ 81 years (presence; ORs: 1.523; 95% CIs: 1.224–1.895), support/care-need certification (presence; ORs: 1.815; 95% CIs: 1.361–2.394), periodontal pocket depth (PPD) ≥ 4 mm (presence; ORs: 1.469; 95% CIs: 1.163–1.856), difficulty in biting hard food (yes; ORs: 1.439; 95% CIs: 1.145–1.808), choking on tea and water (yes; ORs: 2.543; 95% CIs: 2.025–3.193), and dry mouth (yes; ORs: 1.316; 95% CIs: 1.052–1.646) at baseline. Therefore, the dental checkup items associated with a decline in swallowing function after 2 years were a PPD ≥ 4 mm, difficulty in biting hard food, choking on tea and water, and dry mouth. PPD status and confirming to the self-administered questionnaire about biting, choking, and dry mouth may be useful in predicting future decline in swallowing function.

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“…Alpha-blocker is a representative drug used for treating LUTS. 3 , 4 However, it is difficult to administer an alpha-blocker to elderly male patients due to its side effects such as orthostatic hypotension, dizziness, and headache. Therefore, various phytotherapy with few side effects are being studied worldwide.…”

Section: Introductionmentioning

confidence: 99%

Cervi Parvum Cornu complex for men with lower urinary tract symptoms: a multicenter, randomized, double-blind, placebo-controlled trial

Shin,

Yoon,

Kim

et al. 2023

Prostate International

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Lifestyle habits to prevent the development of benign prostatic hyperplasia: Analysis of Japanese nationwide datasets

Cited by 5 publications

References 43 publications

Association Between Neutrophil-to-Lymphocyte Ratio and Benign Prostatic Hyperplasia: Results from the TCLSIH Cohort Study

Association Between Neutrophil-to-Lymphocyte Ratio and Benign Prostatic Hyperplasia: Results from the TCLSIH Cohort Study

Predictive Factors Associated with Future Decline in Swallowing Function among Japanese Older People Aged ≥ 75 Years

Cervi Parvum Cornu complex for men with lower urinary tract symptoms: a multicenter, randomized, double-blind, placebo-controlled trial

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