Lifestyle Factors that can Induce an Independent and Persistent Low-Grade Systemic Inflammatory Response: A Wholistic Approach

Abstract

Abstract:Subclinical inflammation was first shown in numerous chronic medical illnesses and in the early 1900s, activation of immune-inflammatory pathways was initially observed in a lifestyle-related disorder such as depression. A chronic mild inflammatory state is also a key feature of obesity as well as insulin resistance and other metabolic diseases. This particular form of immune process has given rise to the concept of "metaflammation" (metabolically triggered inflammation) because it can target vital organs and tissues that are critical for the regulation of metabolism, and ultimately disrupt systemic homoeostasis with detrimental health effects. However, accumulating evidence demonstrates a link between metaflammation and a number of lifestyle factors. Lifestyle variables such as ultra-endurance exercise, physical inactivity, extremes of sleep duration, cigarette smoking, burnout, anxiety, and depression can activate multiple immune-inflammatory pathways. Therefore, this review of the literature that bears hallmarks of a systematic review investigates and presents published research data of these lifestyle factors that can induce an independent and persistent low-grade systemic inflammatory response, within the human body, evaluated through the measurement of various biomarkers.

Occupational health disparities among U.S. long-haul truck drivers: the influence of work organization and sleep on cardiovascular and metabolic disease risk

“…While the connections between sleep and CMD risk are well established [ 93 , 111 ], in our analyses sleep duration— the length that drivers slept each night, was not a significant predictor. This finding was surprising, given the established connections between sleep duration and cardiometabolic risks among other populations [ 93 , 111 – 113 ]. While it would be inappropriate to wholly disregard the importance of sleep duration among LHTDs, our findings suggest that the occupational milieu of long-haul trucking, where the aforementioned risks regularly compromise sleep quality, may powerfully mediate this relationship.…”

Pandemic Preparedness: The Importance of Adequate Immune Fitness

“…They could choose among the answering possibilities 'never', 'sometimes', 'regularly', 'often', and '(almost) always'. The overall ISQ score, after recoding [10], ranges from 0 (poor) to 10 (excellent). Higher ISQ scores correspond to a better perceived immune status.…”

“…Poor immune fitness is caused in part by genetic predisposition, but it is also significantly impacted by lifestyle factors of the patient. For example, chronic intake of unhealthy food, lack of physical exercise, smoking, alcohol and drug use, chronic stress, and poor sleep all contribute to poorer levels of immune fitness [10]. It can therefore by hypothesized that chronic systemic low-grade inflammation is a risk factor for experiencing a greater number and more severe COVID-19 symptoms.…”

Determination of Atherosclerosis markers changes after HIIT and ginger consumption in response to acute exercise in overweight women

“…Interlukine-10 (IL-10) is one of the key anti-inflammatory cytokines, a polytropic interleukin, which acts in suppression of many inflammatory factors expression such as ICAM-1 and MCP-1 through inhibition of nuclear factor-κB activity (NF-κB) (Talanian et al, 2007). However, available evidence suggests that concentration of ICAM-1, MCP-1and IL-10 can be modulating by pro inflammatory conditions (Vrousgos, 2015), exercise training (Ribeiro et al, 2012) or after coupling with some of natural ingredients of herbs as seen by ginger (Wang et al, 2013).…”