Lifestyle Factors in Late Adolescence Associate With Later Development of Diverticular Disease Requiring Hospitalization

Jarbrink-Sehgal, Maria; Schmidt, Peter T.; Sköldberg, Filip; Hemmingsson, Tomas; Hagström, Hannes; Andréasson, Anna

doi:10.1016/j.cgh.2018.04.006

Cited by 8 publications

(8 citation statements)

References 69 publications

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“…9 In a retrospective analysis of data from 43,772 Swedish men, smokers with different numbers of cigarettes smoked had 37%-60% higher of 2 of developing diverticular disease compared with nonsmokers. 7 Our study with data from 2 populations confirmed the detrimental effect of smoking on diverticular disease and supported the causality of this association. Several mechanisms linking smoking to diverticular disease have been postulated, such as detrimental effects of smoking on intestinal microbiota, 35 inflammation, 36 and abdominal fatness.…”

Section: Discussionsupporting

confidence: 82%

“…16 A null finding was reported for moderate alcohol consumption in relation to diverticular disease in two large-scale cohort studies. 7,12 Nonetheless, heavy alcohol consumption (or risky alcohol consumption) and alcohol abuse were revealed to increase the risk of diverticular disease. 7,15,17 The present MR study found an unclear pattern of association between moderate alcohol consumption and risk of diverticular disease and a largely different tendency of this association in 2 populations.…”

Section: Discussionmentioning

confidence: 99%

“…7,12 Nonetheless, heavy alcohol consumption (or risky alcohol consumption) and alcohol abuse were revealed to increase the risk of diverticular disease. 7,15,17 The present MR study found an unclear pattern of association between moderate alcohol consumption and risk of diverticular disease and a largely different tendency of this association in 2 populations. Given that alcohol consumption was an aggregated measure of intake of all types of alcoholic beverages, the observed discrepancy in associations between FinnGen and UK Biobank might be caused by differences in alcohol behaviors (eg, type of alcoholic beverages, frequency of consumption, the quantity on each occasion) between the 2 countries.…”

Section: Discussionmentioning

confidence: 99%

“…D iverticular disease is a common gastrointestinal disease with an increasing prevalence and a great economic burden. [1][2][3] Epidemiological studies have generated robust evidence that adiposity [3][4][5][6][7][8] and smoking 7,9 increase the risk of diverticular disease. The role of other potentially modifiable risk factors, such as type 2 diabetes, [10][11][12][13] alcohol drinking, 7,12,[14][15][16][17] and coffee consumption, 15,18 in diverticular disease has been scarcely investigated and the evidence is inconsistent, possibly because of residual confounding and other biases.…”

mentioning

confidence: 99%

“…[1][2][3] Epidemiological studies have generated robust evidence that adiposity [3][4][5][6][7][8] and smoking 7,9 increase the risk of diverticular disease. The role of other potentially modifiable risk factors, such as type 2 diabetes, [10][11][12][13] alcohol drinking, 7,12,[14][15][16][17] and coffee consumption, 15,18 in diverticular disease has been scarcely investigated and the evidence is inconsistent, possibly because of residual confounding and other biases. A clear appraisal of the causality of these associations is of importance in updating the primary prevention strategy for diverticular disease.…”

mentioning

confidence: 99%

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Genetically Predicted Adiposity, Diabetes, and Lifestyle Factors in Relation to Diverticular Disease

Yuan

Larsson

2022

Clinical Gastroenterology and Hepatology

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Higher exposure Lower exposure Mendelian randomization design Obesity Type 2 diabetes Smoking Diverticular disease data from • FinnGen (10 978 cases and 149 001 controls) • UK Biobank (12 662 cases and 348 532 controls) Results and conclusions Coffee intake Alcohol intake risk risk risk Analysis • Inverse-variance weighted method • Weighted median method • MR-Egger method • MR-PRESSO method • Contamination mixture method Random allocation of effect alleles BACKGROUND & AIMS:Adiposity, type 2 diabetes, alcohol and coffee consumption, and smoking have been examined in relation to diverticular disease in observational studies. We conducted a Mendelian randomization study to assess the causality of these associations. METHODS:Independent genetic instruments associated with the studied exposures at genome-wide significance were obtained from published genome-wide association studies. Summary-level data for the exposure-associated single nucleotide polymorphisms with diverticular disease were available in the FinnGen consortium (10,978 cases and 149,001 noncases) and the UK Biobank study (12,662 cases and 348,532 noncases). RESULTS:Higher genetically predicted body mass index and genetic liability to type 2 diabetes and smoking initiation were associated with an increased risk of diverticular disease in metaanalyses of results from the two studies. The combined odds ratio of diverticular disease was 1.23 (95% confidence interval [CI], 1.14-1.33; P < .001) for a 1-standard deviation (~4.8 kg/m 2 ) increase in body mass index, 1.04 (95% CI, 1.01-1.07; P ¼ .007) for a 1-unit increase in logtransformed odds ratio of type 2 diabetes, and 1.21 (95% CI, 1.12-1.30; P < .001) for a 1standard deviation increase in prevalence of smoking initiation. Coffee consumption was not associated with diverticular disease, whereas the association for alcohol consumption largely differed between the 2 studies.

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