Lifestyle factors during acute Epstein–Barr virus infection in adolescents predict physical activity six months later

Pedersen, Maria; Asprusten, Tarjei Tørre; Godang, Kristin; Leegaard, Truls Michael; Osnes, Liv; Skovlund, Eva; Tjade, Trygve; Øie, Merete Glenne; Wyller, Vegard Bruun

doi:10.1111/apa.14728

Cited by 3 publications

(3 citation statements)

References 27 publications

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“…18 Premorbid lifestyle factors have also been related to prolonged recoveries. 79 Unfortunately, the studies above provide little insight into the underlying biological mechanisms responsible for delayed EBV viral recovery.…”

Section: Postviral Fatigue Syndromesmentioning

confidence: 99%

A clinical primer for the expected and potential post-COVID-19 syndromes

Walitt

Bartrum

2021

PR9

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In late 2019, a novel coronavirus SARS-CoV-2 (COVID-19) spread unchecked across the world's population. With tens of millions infected, the long-term consequences of COVID-19 infection will be a major health care focus for years after the contagion subsides. Most complications stem from direct viral invasion provoking an over-exuberant inflammatory response driven by innate immune cells and activation of the clotting cascade causing thrombosis. Injury to individual organs and their protective linings are frequent presentations in respiratory, cardiovascular, and neurological systems. Reviewing the historical context of postviral fatiguing symptoms seems relevant to understanding reports of uneven recoveries and persistent symptoms that are emerging as "long-haul COVID-19." The pandemic is also an unprecedented sociocultural event, transforming how people consider their health, gather in groups, and navigate their daily lives. The unprecedented sociocultural stresses of the pandemic will have an invisible, ubiquitous, and predictable impact on neurologic, endocrine, and immune functioning, even in people untouched by the virus. COVID-19 may also have a surprise or two in store, with unique clinical presentations and novel mechanisms of injury which are yet to clearly emerge. Although challenging and unfortunate, these times also represent a unique opportunity to start to unravel the physiology that underlie how viruses may trigger cancers, neurological disease, and postviral fatiguing syndromes.

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Section: Postviral Fatigue Syndromesmentioning

confidence: 99%

A clinical primer for the expected and potential post-COVID-19 syndromes

Walitt

Bartrum

2021

PR9

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“…Em contrapartida, indivíduos sedentários continuam a sentir fadiga excessiva mesmo após seis meses do início do quadro clínico (PEDERSEN et al, 2019). Além disso, o exercício frequente de longa duração tem a capacidade de aumentar a circulação de linfócitos (HE et al, 2013), incluindo os de memória específicos contra antígenos do HHV-4 (KUNZ et al, 2020;SPIELMANN et al, 2016), o que favorece a resposta imune no controle da infecção.…”

Section: Vírusunclassified

Influência do exercício físico no desfecho de infecções virais: revisão bibliográfica de duas décadas de evidências

Bertoni

Caixa

Oliveira³

et al. 2021

R. bras. Qual. Vida

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OBJETIVO: Sumarizar as evidências das últimas duas décadas sobre o efeito do exercício no desfecho de diferentes infecções virais.MÉTODOS: Foi realizada busca de artigos científicos nas bases de dados PubMed, Google Acadêmico, SciELO, LILACS e Web of Science, publicados entre 2001 e 2020, que relacionaram a atividade física com infecções virais. Após análise de título, resumo e texto completo, foram selecionados os que atendiam ao objetivo da pesquisa, excluindo trabalhos com animais, artigos de revisão ou publicados em idiomas que não fossem o português, inglês e espanhol. Após seleção final, foi realizado fichamento dos textos e escrita da revisão.RESULTADOS: Após busca e aplicação dos critérios de exclusão foram selecionados 49 artigos. A maior parte das publicações se concentravam nas temáticas do vírus da imunodeficiência humana e os herpesvírus humanos tipos 4 e 5. Em menor medida foram encontradas pesquisas sobre a relação da atividade física e os vírus das hepatites B e C, vírus T-linfotrópico humano do tipo 1 e alguns vírus causadores de infecção no trato respiratório.CONCLUSÕES: Exercícios físicos intensos podem ser prejudiciais (ou até inviáveis) para infectados por Herpesvírus humano tipos 4 e 5 e vírus Influenza, pacientes com hepatites B e/ou C crônicas em estágio avançado de hepatopatia ou com paraparesia espástica tropical causada pelo Vírus T-linfotrópico humano do tipo 1 (HTLV-1). Em geral, a atividade física não desgastante e regular é benéfica para prevenir o adoecimento e o desenvolvimento de quadros clínicos graves ou fatais.

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“…Since EBV and Pf infections are known contributors to eBLassociated malignancies, eBL is influenced indirectly by environmental factors such as climate, rainfall, and vegetation that affect the burden and transmission of Pf [16]. Further, the age of primary infection and severity of EBV infection is influenced by the lifestyle of the inhabitants with the majority of children being infected by EBV within their first years of life [17].…”

Section: Introductionmentioning

confidence: 99%

Profiling genome-wide recombination in Epstein Barr virus reveals type-specific patterns and associations with endemic-Burkitt lymphoma

Agwati

Oduor

Ayieko

et al. 2022

Virol J

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Background Endemic Burkitt lymphoma (eBL) is potentiated through the interplay of Epstein Barr virus (EBV) and holoendemic Plasmodium falciparum malaria. To better understand EBV’s biology and role in eBL, we characterized genome-wide recombination sites and patterns as a source of genetic diversity in EBV genomes in our well-defined population of eBL cases and controls from Western Kenya. Methods EBV genomes representing 54 eBL cases and 32 healthy children from the same geographic region in Western Kenya that we previously sequenced were analyzed. Whole-genome multiple sequence alignment, recombination analyses, and phylogenetic inference were made using multiple alignment with fast Fourier transform, recombination detection program 4, and molecular evolutionary genetics analysis. Results We identified 28 different recombination events and 71 (82.6%) of the 86 EBV genomes analyzed contained evidence of one or more recombinant segments. Associated recombination breakpoints were found to occur in a total of 42 different genes, with only 7 (16.67%) being latent genes. Recombination events were major drivers of clustering within genome-wide phylogenetic trees. The occurrence of recombination segments was comparable between genomes from male and female participants and across age groups. More recombinant segments were found in EBV type 1 genomes (p = 6.4e − 06) and the genomes from the eBLs (p = 0.037). Two recombination events were enriched in the eBLs; event 47 (OR = 4.07, p = 0.038) and event 50 (OR = 14.24, p = 0.012). Conclusions EBV genomes have extensive evidence of recombination likely acquired progressively and cumulatively over time. Recombination patterns display a heterogeneous occurrence rate across the genome with enrichment in lytic genes. Overall, recombination appears to be a major evolutionary force impacting EBV diversity and genome structure with evidence of the association of specific recombinants with eBL.

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Lifestyle factors during acute Epstein–Barr virus infection in adolescents predict physical activity six months later

Cited by 3 publications

References 27 publications

A clinical primer for the expected and potential post-COVID-19 syndromes

A clinical primer for the expected and potential post-COVID-19 syndromes

Influência do exercício físico no desfecho de infecções virais: revisão bibliográfica de duas décadas de evidências

Profiling genome-wide recombination in Epstein Barr virus reveals type-specific patterns and associations with endemic-Burkitt lymphoma

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